BX-912

Catalog No.: A11149

PDK1 inhibitor

BX-912

BX-912 Chemical Structure

CAS NO. 702674-56-4

BX-912 is an inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1).

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
50 mg
$520.00
100 mg
$780.00
10mM * 1mL in DMSO
$144.00
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Biological Activity

BX-912 is an inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1).
Targets
Target Value
PDK-1IC50: 12nM
PKAIC50: 110nM
KDRIC50: 410nM
CDK2/CyclinEIC50: 650nM
Chk1IC50: 830nM
c-KitIC50: 850nM
PKCIC50: 1.25μM
T-FynIC50: 2.1μM
Insulin ReceptorIC50: 6.1μM
GSK-3βIC50: 7.4μM
EGFRIC50: >10μM
In vitro (25°C) DMSO 94 mg/mL (199.42 mM)
Water <1 mg/mL (<1 mM)
Ethanol 94 mg/mL (199.42 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.21 mL 106.07 mL 212.13 mL
0.5 mM 4.24 mL 21.21 mL 42.43 mL
1 mM 2.12 mL 10.61 mL 21.21 mL
5 mM 0.42 mL 2.12 mL 4.24 mL

*The above data is based on the productmolecular weight 471.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11149
Actions Inhibitor
M. Wt 471.4
Formula C20H23BrN8O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 702674-56-4
Synonyms BX912
SMILES C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCC4=CN=CN4)Br

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