c-Kit

Catalog No.Inhibitor Name c-KitOther
A10290Dasatinib
***
Abl,Src
A10468Imatinib Mesylate
**
PDGFR,v-Abl
A10996Cabozantinib
***
VEGFR2/KDR,c-Met,VEGFR3/FLT4
A10103Axitinib
****
VEGFR1/FLT1,VEGFR2/Flk1,VEGFR2/KDR
A10699Pazopanib HCl
*
VEGFR1,VEGFR2,VEGFR3
A11411Dovitinib
****
FLT3,FGFR1,VEGFR3/FLT4
A10967Vatalanib 2HCl
*
VEGFR2/KDR,VEGFR1/FLT1,VEGFR2/Flk1
A10558Masitinib
*
Lyn B,PDGFRα,PDGFRβ
A10101Tivozanib
**
VEGFR2,VEGFR3,EphB2
A10610Amuvatinib
***
PDGFRα (V561D),FLT3 (D835Y)
A10608Motesanib Diphosphate
***
VEGFR1,VEGFR2,VEGFR2/Flk1
A10679OSI-930
**
FLT1,KDR,CSF-1R
A10502Ki8751
**
VEGFR2,PDGFRα,FGFR2
A10903Telatinib
****
VEGFR3,VEGFR2,PDGFRα
A11518Pazopanib
*
VEGFR1,VEGFR2,VEGFR3
A10198Dovitinib Dilactic Acid
****
FLT3,FGFR1,VEGFR3/FLT4
A16320Dasatinib Monohydrate
***
Abl ,Src
A14156AZD2932
***
PDGFRβ,Flt3,VEGFR-2
A10880Sunitinib Malate
FLT3,PDGFRβ,VEGFR2
A15062DCC-2618
***
PDGFRα, PDGFRβ
A15519PLX647
***
Fms
A15520Pexidartinib (PLX3397)
***
CSF-1R, Flt-3

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

40 Item(s)

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  1. Ki 20227

    Catalog No. A11472
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    M-CSFR, CSF1R inhibitor
    Ki 20227 is an inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R). Learn More
  2. Regorafenib Hydrochloride

    Catalog No. A11546
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    VEGFR1/2/3/PDGFRβ/Kit/RET/Raf-1 inhibitor
    Regorafenib Hydrochloride is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively. Learn More
  3. CHMFL-ABL/KIT-155

    Catalog No. A12421
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    ABL/c-KIT dual kinase inhibitor
    CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor. Learn More
  4. c-Kit-IN-2

    Catalog No. A18440
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    c-KIT inhibitor
    c-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively. Learn More
  5. CHMFL-KIT-033

    Catalog No. A18476
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    c-KIT T670I mutant inhibitor
    CHMFL-KIT-033 is a potent and selective inhibitor of c-KIT T670I mutant for gastrointestinal stromal tumors (GISTs), with an IC50 of 0.045 μM. Learn More
  6. Dasatinib Monohydrate

    Catalog No. A16320
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    Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively. Learn More
  7. AC710 Mesylate

    Catalog No. A16246
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    FLT3/KIT/PDGFRα/PDGFRβ inhibitor
    AC710 Mesylate is a potent, selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM/1.0 nM/1.3 nM/1.0 nM for FLT3/KIT/PDGFRα/PDGFRβ respectively. Learn More
  8. AC710

    Catalog No. A15933
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    FLT3/KIT/PDGFRα/PDGFRβ inhibitor
    AC710 is a potent, orally active, and selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity. Learn More
  9. Pexidartinib (PLX3397)

    Catalog No. A15520
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    CSF1/Kit/FLT3 inhibitor
    Pexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Learn More
  10. Masitinib mesylate

    Catalog No. A15152
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    KIT/PDGFR inhibitor
    Masitinib mesylate is a novel inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms. Learn More
  11. Regorafenib (BAY 73-4506)

    Catalog No. A10250
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    VEGFR inhibitor
    Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. Learn More
  12. Pazopanib (GW-786034)

    Catalog No. A11518
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    VEGFR inhibitor
    Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More
  13. Ki8751

    Catalog No. A10502
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    VEGFR-2 inhibitor
    Ki8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays. Learn More
  14. Sunitinib Malate

    Catalog No. A10880
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    RTK inhibitor
    Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). Learn More
  15. Imatinib (Gleevec)

    Catalog No. A10259
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    PDGFR inhibitor
    Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor. Learn More
  16. Axitinib

    Catalog No. A10103
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    VEGFR inhibitor
    Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117). Learn More
  17. XL184 free base (Cabozantinib)

    Catalog No. A10996
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    VEGFR inhibitor
    XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2. Learn More
  18. Masitinib ( AB1010)

    Catalog No. A10558
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  19. Imatinib Mesylate

    Catalog No. A10468
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    Bcr-Abl inhibitor
    Imatinib mesylate, a selective tyrosine kinase inhibitor, induced a sustained objective response in treating gastrointestinal stromal tumors with the inhibition of the KIT signal-transduction pathway. Learn More
  20. Dovitinib (TKI-258)

    Catalog No. A11411
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    RTK inhibitor
    Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively. Learn More
  21. Dasatinib (BMS-354825)

    Catalog No. A10290
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    Abl-Src inhibitor
    Dasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2. Learn More
  22. Tivozanib (AV-951)

    Catalog No. A10101
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    VEGFR Inhibitor
    Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors. Learn More
  23. Pazopanib HCl (GW786034)

    Catalog No. A10699
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    VEGFR/PDGFR/FGFR inhibitor
    Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More
  24. AST 487

    Catalog No. A15003
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    RET kinase inhibitor
    AST487 is a Ret kinase inhibitor/FLT3 inhibitor with IC50 of 0.88 uM for Ret. Learn More
    • New

    ISCK03

    Catalog No. A17162
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    c-kit inhibitor
    ISCK03 is a potent c-kit inhibitor. Learn More
  25. AZD3229 Tosylate

    Catalog No. A16867
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    pan-KIT mutant inhibitor
    AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. Learn More
  26. Flumatinib

    Catalog No. A16258
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    multi-kinase inhibitor
    Flumatinib is a multi-kinase inhibitor with IC50 Values of 1.2 nM, 307.6 nM and 2662 nM for c-Abl, PDGFRbeta and c-Kit respectively. Learn More
  27. MP470 (MP-470, Amuvatinib)

    Catalog No. A10610
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    RTK inhibitor
    MP470 is a c-Kit/PDGFR tyrosine kinase inhibitor. Learn More
  28. Vatalanib (PTK787) 2HCl

    Catalog No. A10967
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    VEGFR inhibitor
    Vatalanib (PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis that inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for VEGFR-2. CAS: 212141-51-0 (HCl) 212141-54-3 (Free base) Learn More
  29. PLX647

    Catalog No. A15519
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    FMS/KIT inhibitor
    PLX647 is a highly specific dual FMS/KIT kinase inhibitor with IC50 of 28/16 nM respectively. Learn More
  30. Regorafenib monohydrate

    Catalog No. A15218
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    Tyrosine kinase inhibitor
    Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. Learn More
  31. N-Desethyl Sunitinib

    Catalog No. A15182
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    VEGFR/PDGFRβ/KIT inhibitor
    N-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively). Learn More
  32. DCC-2618

    Catalog No. A15062
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    C-Kit/PDGFR inhibitor
    DCC-2618 is a small molecule inhibitor of c-Kit and PDGFR with IC50s of 6 nM/30 nM/13 nM for c-Kit/PDGFRα/PDGFRβ respectively. Learn More
  33. AZD 2932

    Catalog No. A14156
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    mutil-targeted protein tyrosine kinase inhibitor
    AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively. Learn More
  34. Flumatinib mesylate

    Catalog No. A13530
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    c-Abl/c-Kit/PDGRFβ inhibitor
    Flumatinib mesylate can reduce the expression of C-MYC, HIF-1 a and VEGF in U266 cell line in a time- and dose-dependent manners, so flumatinib mesylate may become a new drug for MM therapy. Learn More
  35. Toceranib (PHA 291639, SU 11654)

    Catalog No. A11581
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    c-Kit, PDGFR, VEGFR inhibitor
    Toceranib is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. Learn More
  36. Telatinib (BAY 57-9352)

    Catalog No. A10903
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    VEGFR-2 inhibitor
    Telatinib (BAY 57-9352) is an orally available, small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and platelet-derived growth factor receptor β tyrosine kinases. Learn More
  37. Motesanib Diphosphate (AMG-706)

    Catalog No. A10608
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    VEGFR inhibitor
    Motesanib, also known as AMG-706, is an orally administered multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors, and Kit receptors. Learn More
  38. Dovitinib Dilactic acid (TKI258 Dilactic acid)

    Catalog No. A10198
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    RTK inhibitor
    Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively. Learn More
  39. OSI-930

    Catalog No. A10679
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    c-Kit/VEGFR Inhibitor
    OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively. Learn More

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