c-Ret

Catalog No.Inhibitor Name c-RETOther
A10250Regorafenib
****
Raf-1,VEGFR2,Kit
A10715Danusertib
**
Aurora A,Abl,TrkA
A11180TG101209
***
JAK2,FLT3,JAK3
A13832RPI-1
*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

5 Item(s)

per page

Set Descending Direction
  1. Regorafenib (BAY 73-4506)

    Catalog No. A10250
    Quick View
    VEGFR inhibitor
    Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. Learn More
  2. Danusertib (PHA-739358)

    Catalog No. A10715
    Quick View
    Aurora inhibitor
    Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2 Learn More
  3. TG101209

    Catalog No. A11180
    Quick View
    JAK2 inhibitor

    TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.

    Learn More
  4. RPI-1

    Catalog No. A13832
    Quick View
    Ret kinase inhibitor
    RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor. Learn More
  5. Regorafenib monohydrate

    Catalog No. A15218
    Quick View
    Tyrosine kinase inhibitor
    Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. Learn More

5 Item(s)

per page

Set Descending Direction
Rewards