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| Catalog No. | Inhibitor Name | c-RET | Other |
|---|---|---|---|
| A10250 | Regorafenib | **** | Raf-1,VEGFR2,Kit |
| A10715 | Danusertib | ** | Aurora A,Abl,TrkA |
| A11180 | TG101209 | *** | JAK2,FLT3,JAK3 |
| A13832 | RPI-1 | * |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Regorafenib (BAY 73-4506)
Catalog No. A10250 VEGFR inhibitorRegorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. Learn More -
Danusertib (PHA-739358)
Catalog No. A10715 Aurora inhibitorDanusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2 Learn More -
TG101209
Catalog No. A11180 JAK2 inhibitorTG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.
Learn More -
RPI-1
Catalog No. A13832 Ret kinase inhibitorRPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor. Learn More -
Regorafenib monohydrate
Catalog No. A15218 Tyrosine kinase inhibitorRegorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. Learn More -
RET-IN-1
Catalog No. A19015 RET inhibitorRET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively . Learn More -
Regorafenib Hydrochloride
Catalog No. A11546 VEGFR1/2/3/PDGFRβ/Kit/RET/Raf-1 inhibitorRegorafenib Hydrochloride is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively. Learn More -
cis-Pralsetinib
Catalog No. A21586 RET inhibitorcis-Pralsetinib (cis-BLU-667) is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50s ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types. Learn More -
BBT594
Catalog No. A21039 RET inhibitorBBT594 is a potent receptor tyrosine kinase RET inhibitor, used for cancer treatment. Learn More
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- Abl (1)
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- FGFR1 (1)
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- RET (5)
- TrkA (1)
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- VEGFR3 (FLT4) (1)
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