Canertinib (CI-1033)

Catalog No.: A10211

HER2/ErbB2 inhibitor

Canertinib (CI-1033)

Canertinib (CI-1033) Chemical Structure

CAS NO. 267243-28-7

Canertinib (CI-1033) is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM).

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Package Price Qty
10 mg
$50.00
50 mg
$85.00
200 mg
$210.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Fukuda N, .et al. Rapid Evaluation of Tyrosine Kinase Activity of Membrane Integrated Human Epidermal Growth Factor Receptor Using the Yeast Gγ Recruitment System, ACS Synth Biol., 2015, 4(4):421-9 PMID: 25006755

Biological Activity

Canertinib (CI-1033) is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM).
Targets
EGFR (Cell-free assay) ErbB2 (Cell-free assay)
1.5 nM9.0 nM
In vitro (25°C) DMSO 2 mg/mL (4.11 mM)
Water Insoluble
Ethanol 8 mg/mL (16.46 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.58 mL 102.9 mL 205.8 mL
0.5 mM 4.12 mL 20.58 mL 41.16 mL
1 mM 2.06 mL 10.29 mL 20.58 mL
5 mM 0.41 mL 2.06 mL 4.12 mL

*The above data is based on the productmolecular weight 485.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10211
Actions Inhibitor
CAS No. 267243-28-7
Formula C24H25ClFN5O3
M. Wt 485.9
Purity >98%
Synonyms CI-1033, CI1033, PD-183805
SMILES C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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