Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
- Fukuda N, .et al. Rapid Evaluation of Tyrosine Kinase Activity of Membrane Integrated Human Epidermal Growth Factor Receptor Using the Yeast Gγ Recruitment System, ACS Synth Biol., 2015, 4(4):421-9 PMID: 25006755
Biological Activity
Canertinib (CI-1033) is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM).
Targets
EGFR (Cell-free assay) | ErbB2 (Cell-free assay) | |||
1.5 nM | 9.0 nM |
In vitro (25°C) | DMSO | 2 mg/mL (4.11 mM) | |
Water | Insoluble | ||
Ethanol | 8 mg/mL (16.46 mM) | ||
In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 9 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 20.58 mL | 102.9 mL | 205.8 mL |
0.5 mM | 4.12 mL | 20.58 mL | 41.16 mL |
1 mM | 2.06 mL | 10.29 mL | 20.58 mL |
5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
*The above data is based on the productmolecular weight 485.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10211 |
---|---|
Actions | Inhibitor |
CAS No. | 267243-28-7 |
Formula | C24H25ClFN5O3 |
M. Wt | 485.9 |
Purity | >98% |
Synonyms | CI-1033, CI1033, PD-183805 |
SMILES | C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
AG-18 (Tyrphostin 23)
AG-18 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 35 ,M in the human epidermoid carcinoma cell li…
BIBW2992 (Afatinib)
BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epider…
ARRY334543 (Varlitinib)
ARRY334543 is a potent, orally active small molecule inhibitor of EGFR and ErbB-2.
ARRY-543 (Varlitinib, ASLAN001)
ARRY-543 is a novel, oral ErbB family inhibitor that, unlike approved ErbB inhibitors, targets all members of the ErbB family, including Erb…
WZ3146
WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less pot…
ASP8273 (Naquotinib)
ASP8273 is an orally available, irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with po…
Pelitinib (EKB-569)
Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
XL647 (Tesevatinib)
XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major ro…
Keywords:buy Canertinib (CI-1033) | Canertinib (CI-1033) Supplier | purchase | cost | manufacturer | order | distributor | buy 267243-28-7| 267243-28-7 Supplier | purchase 267243-28-7 | 267243-28-7 cost | 267243-28-7 manufacturer | order 267243-28-7 | 267243-28-7 distributor