Canertinib (CI-1033)

Name: Canertinib (CI-1033)
Brand: Adooq Bioscience
SKU: A10211
Rating: 100 (1 reviews)

Catalog No.: A10211

HER2/ErbB2 inhibitor

Product Citations (1)

Canertinib (CI-1033) Chemical Structure

CAS NO. 267243-28-7

Canertinib (CI-1033) is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM).

Availability: In stock

Package	Price	Qty
10 mg	$50.00
50 mg	$85.00
200 mg	$210.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Canertinib (CI-1033)

Fukuda N, .et al. Rapid Evaluation of Tyrosine Kinase Activity of Membrane Integrated Human Epidermal Growth Factor Receptor Using the Yeast Gγ Recruitment System, ACS Synth Biol., 2015, 4(4):421-9 PMID: 25006755

Biological Activity

Canertinib (CI-1033) is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM).

Targets

EGFR (Cell-free assay)	ErbB2 (Cell-free assay)
1.5 nM	9.0 nM

Solubility *

In vitro (25°C)	DMSO	2 mg/mL (4.11 mM)
	Water	Insoluble
	Ethanol	8 mg/mL (16.46 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.58 mL	102.9 mL	205.8 mL
0.5 mM	4.12 mL	20.58 mL	41.16 mL
1 mM	2.06 mL	10.29 mL	20.58 mL
5 mM	0.41 mL	2.06 mL	4.12 mL

*The above data is based on the productmolecular weight 485.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10211
Actions	Inhibitor
CAS No.	267243-28-7
Formula	C24H25ClFN5O3
M. Wt	485.9
Purity	>98%
Synonyms	CI-1033, CI1033, PD-183805
SMILES	C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.