Canertinib (CI-1033)

Catalog No.: A10211

HER2/ErbB2 inhibitor

Canertinib (CI-1033)

Canertinib (CI-1033) Chemical Structure

CAS NO. 267243-28-7

Canertinib (CI-1033) is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM).

Availability: In stock

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10 mg
$50.00
50 mg
$85.00
200 mg
$210.00
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Biological Activity

Canertinib (CI-1033) is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM).
Targets
EGFR (Cell-free assay) ErbB2 (Cell-free assay)
1.5 nM9.0 nM
In vitro (25°C) DMSO 2 mg/mL (4.11 mM)
Water <1 mg/mL (<1 mM)
Ethanol 9 mg/mL (18.52 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.58 mL 102.9 mL 205.8 mL
0.5 mM 4.12 mL 20.58 mL 41.16 mL
1 mM 2.06 mL 10.29 mL 20.58 mL
5 mM 0.41 mL 2.06 mL 4.12 mL

*The above data is based on the productmolecular weight 485.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10211
Actions Inhibitor
M. Wt 485.9
Formula C24H25ClFN5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 267243-28-7
Synonyms CI-1033, CI1033, PD-183805
SMILES C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

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