Search results for '2c c hcl'

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  1. Grifolic Acid

    Catalog No. A19590
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    Grifolic acid is a selective partial agonist of GPR120 that induces ERK activation and intracellular calcium responses in mouse enteroendocrine STC-1 cells. Learn More
  2. S-Scoulerine

    Catalog No. A18990
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  3. Levofloxacin

    Catalog No. A10528
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    Levofloxacin is a fluoroquinolone antibiotic. It is active against S. aureus, S. epidermidis, B. subtilis, E. coli, P. aeruginosa, and K. pneumoniae (MICs = 0.25, 0.25, 0.5, 0.03, 4, and 0.25 μg/ml, respectively). Learn More
  4. Bruceantin

    Catalog No. A19811
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    Bruceantin(NSC165563) is first isolated from Brucea antidysenterica. Learn More
    • -20%

    Rapamycin (Sirolimus)

    Catalog No. A10782-2000
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    mTOR Inhibitors
  5. Dexrazoxane

    Catalog No. A17714
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    topoisomerase IIα inhibitor
    Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα. Learn More
  6. CFI-402257

    Catalog No. A12037
    TTK inhibitor
    CFI-402257, a pyrazolopyridin derivative, has been found to be a TTK inhibitor that could influence chromosome segregation and induce cell death so that is significant in anticancer studies. Learn More
    • New

    AMG-510 (Sotorasib)

    Catalog No. A19021
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    KRAS G12C covalent inhibitor
    AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity. Learn More
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    Adooq Payment Adjustment

    Catalog No. ADQPA
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    It is for the online credit card payment only, not for any product order placement. Learn More
  7. Auranofin

    Catalog No. A18996
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    Auranofin is a gold salt classified by the World Health Organization as an antirheumatic agent. It is a gold-thiol complex with anti-inflammatory and immunosuppressive actions. Learn More
  8. MALAT1-IN-1

    Catalog No. A18822
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    Malat1 inhibitor
    MALAT1-IN-1 is a potent and specific Malat1 (Metastasis-associated lung adenocarcinoma transcript 1) inhibitor. Learn More
  9. 2-APB

    Catalog No. A18088
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    IP3R inhibitor
    2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3). Learn More
  10. ML-9 hydrochloride

    Catalog No. A17856
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    MLCK inhibitor
    ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation. Learn More
  11. 9-Phenanthrol

    Catalog No. A17570
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    TRPM4 blocker
    Selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model. Learn More
  12. Zanubrutinib (BGB-3111)

    Catalog No. A22044
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    BTK inhibitor
    Zanubrutinib (BGB-3111) is a selective Bruton tyrosine kinase (BTK) inhibitor. Learn More
  13. kb-NB77-78

    Catalog No. A22043
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    kb-NB77-78 is an analogue of CID797718, but shows no PKD inhibitory activity. Learn More
  14. Dofequidar

    Catalog No. A22042
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    sphingomyelin synthase inhibitor
    Dofequidar, also known as MS-209, is a quinolone-derived sphingomyelin synthase inhibitor that blocks P-glycoprotein and multidrug resistance-associated protein-1, is under development by Schering for the potential treatment of multidrug resistant tumors. Learn More
  15. Verdiperstat (AZD3241)

    Catalog No. A22041
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    MPO inhibitor
    Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders. Learn More
  16. Rubitecan

    Catalog No. A22040
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    topoisomerase I inhibitor
    Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells. Learn More
  17. Mps1-IN-2

    Catalog No. A22039
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    dual Mps1/Plk1 inhibitor
    Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1. Learn More
  18. Litronesib (LY2523355)

    Catalog No. A22038
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    mitosis-specific kinesin Eg5 inhibitor
    Litronesib is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity. Learn More
  19. BGT226 (free base)

    Catalog No. A22037
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    PI3K /mTOR dual inhibitor
    BGT226 (NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells. Learn More
  20. UNC0379 TFA

    Catalog No. A22036
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    SETD8 inhibitor
    UNC0379 TFA is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM; selective over 15 other methyltransferases. Learn More
  21. GC7 Sulfate

    Catalog No. A22035
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    DHPS inhibitor
    GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor. Learn More
  22. Trilaciclib hydrochloride

    Catalog No. A22034
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    CDK4/6 inhibitor
    Trilaciclib hydrochloride is a CDK4/6 inhibitor with IC50s of 1 nM and 4 nM for CDK4 and CDK6, respectively. Learn More
  23. GW311616

    Catalog No. A22033
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    HNE inhibitor
    GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22 nM and Ki value of 0.31 nM. Learn More
  24. Zoliflodacin

    Catalog No. A22032
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    DNA gyrase/topoisomerase inhibitor
    Zoliflodacin (ETX0914;AZD0914) is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. Learn More
  25. Sardomozide

    Catalog No. A22031
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    SAMDC inhibitor
    Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM. Learn More
  26. Sevelamer

    Catalog No. A22030
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    Sevelamer is a phosphate binding drug used to treat hyperphosphatemia in patients with chronic kidney disease; consists of polyallylamine that is crosslinked with epichlorohydrin. Learn More
  27. K 01-162

    Catalog No. A22029
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    K 01-162 (K162) binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM. Learn More
  28. Naluzotan

    Catalog No. A22028
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    5-HT1A agonist
    Naluzotan is a novel, potent, and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr 20 nM and 5.1 nM, used for the treatment of anxiety and depression; Also a weak hERG K+ channel blocker, with IC50 of 3800 nM. Learn More
  29. IT1t dihydrochloride

    Catalog No. A22027
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    CXCR4 antagonist
    IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. Learn More
  30. THZ2

    Catalog No. A22026
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    CDK7 inhibitor
    THZ2 is a potent and selective CDK7 inhibitor with an IC50 of 13.9 nM. Learn More
  31. LY2510924

    Catalog No. A22025
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    CXCR4 antagonist
    LY2510924 is a potent and selective CXCR4 antagonist that blocks SDF-1 binding to CXCR4 with an IC50 of 0.079 nM. Learn More
  32. MB-07729

    Catalog No. A22024
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    FBPase noncompetitive inhibitor
    MB-07729 is a potent fructose 1,6-bisphosphatase (FBPase) noncompetitive inhibitor with IC50 values of 31, 121, and 189 nM for human, monkey, and rat, respectively. Learn More
  33. PNU-159682

    Catalog No. A22023
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    ADCs cytotoxin
    PNU-159682, a highly potent metabolite of the anthracycline nemorubicin (DNA topoisomerase II inhibitor) with outstanding cytotoxicity, is a potent ADCs cytotoxin. Learn More
  34. Oleanolic acid derivative 1

    Catalog No. A22022
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    Oleanolic acid derivative 1 is an oleanolic acid derivative, which is a novel triterpenoid-steroid hybrid molecule. Learn More
  35. Semustine

    Catalog No. A22021
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    DNA alkylator
    Semustine is a DNA alkylator, binds to DNA, and acts as a cancer chemotherapeutic agent. Learn More
  36. Sograzepide

    Catalog No. A22020
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    Gastrin/CCK-B antagonist
    Sograzepide (Netazepide; YF 476; YM-220) is an extremely potent , highly selective and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.1 nM, has inhibitory effect on Gastrin/CCK-A activity with an IC50 of 502 nM. Learn More
  37. CP-547632 hydrochloride

    Catalog No. A22019
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    VEGFR-2/FGFR inhibitor
    CP-547632 hydrochloride is a well-tolerated, orally-bioavailable inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases with IC50s of 11 nM and 9 nM, respectively. Learn More
  38. Nicotinamide riboside chloride

    Catalog No. A22018
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    Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride is used in dietary supplements. Learn More
  39. Hydroxystilbamidine bis(methanesulfonate)

    Catalog No. A22017
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    cellular ribonucleases inhibitor
    Hydroxystilbamidine bis(methanesulfonate), a dye capable of binding to both DNA and RNA, has been found to be a powerful inhibitor of cellular ribonucleases. Learn More
  40. PAβN dihydrochloride

    Catalog No. A22016
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    efflux pump inhibitor
    PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor. Learn More
  41. VER-246608

    Catalog No. A22015
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    PDK inhibitor
    VER-246608 is a potent and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively. Learn More
  42. QNZ46

    Catalog No. A22014
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    NR2C/NR2D-selective NMDA receptor antagonist
    QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). Learn More
  43. MB-07803

    Catalog No. A22013
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    FBPase inhibitor
    MB07803 is an orally available prodrug of a potent, noncompetitive inhibitor (MB07729) of fructose 1,6-bisphosphatase (FBPase), with EC50 of 140 nM and t1/2 of 7.6±2.9 h. Learn More
  44. Oleanolic acid derivative 2

    Catalog No. A22012
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    Oleanolic acid derivative 2 is an oleanolic acid derivative, which is a novel triterpenoid-steroid hybrid molecule. Learn More
  45. Bisindolylmaleimide X hydrochloride

    Catalog No. A22010
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    PKC inhibitor
    Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective protein kinase C (PKC) inhibitor. Learn More
  46. Pridopidine

    Catalog No. A22009
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    D2R antagonist
    Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Learn More
  47. Eplivanserin

    Catalog No. A21967
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    5-HT2 receptor antagonist
    Eplivanserin is a potent, selective and orally available 5-HT2 receptor antagonist, with an IC50 of 5.8 nM in rat cortical membrane, and a Kd of 1.14 nM. Learn More

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