Search results for 'alz 801'

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  1. JTC-801

    Catalog No. A11076
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    Opioid Receptor antagonist
    JTC-801 is a selective antagonist for the nociceptin receptor, also known as the ORL-1 receptor. Learn More
  2. (+)-MK 801 Maleate

    Catalog No. A12761
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    NMDA receptor antagonist
    (+)-MK 801 is a potent antagonist of NMDA with Ki value of 30.5nM. Learn More
  3. (-)-MK 801 maleate

    Catalog No. A13435
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    NMDA receptor antagonist.
    (-)-MK 801 maleate acts as a potent, selective, and non-competitive NMDA receptor antagonist. It acts by binding to a site located within the NMDA associated ion channel. Learn More
  4. CBS9106

    Catalog No. A19643
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    CRM1 inhibitor
    CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities. Learn More
  5. Bicyclol

    Catalog No. A18133
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    hepatoprotective agent
    Bicyclol, also known as SY 801, is a hepatoprotective agent. Bicyclol upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Learn More
  6. IRAK inhibitor 1

    Catalog No. A11455
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    IRAK-4 inhibitor
    IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively. Learn More
  7. Benfluorex hydrochloride

    Catalog No. A18152
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    HNF4α) activator
    Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator. Learn More
  8. Etifoxine

    Catalog No. A15083
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    Anxiolytic anticonvulsant
    Etifoxine is potentiator of GABAA receptor function in cultured neurons. Learn More
  9. Proscillaridin A

    Catalog No. A13852
    Proscillaridin A is a cardiac glycoside first isolated from plants in the genus Scilla. Learn More
  10. BMS-690514

    Catalog No. A11263
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    VEGFR/EGFR Inhibitor
    BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4, as well as the VEGF receptor kinases. Learn More
  11. Durlobactam sodium

    Catalog No. A13801
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    beta-lactamase inhibitor drug candidate
    Durlobactam, also known as ETX2514, is a beta-lactamase inhibitor drug candidate. Learn More
  12. Molnupiravir

    Catalog No. A22165
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    broad-spectrum antiviral activity
    Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19. Learn More
  13. Pyridoxine

    Catalog No. A22350
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    antioxidant agent
    Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. Learn More
  14. Emavusertib

    Catalog No. A22489
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    Emavusertib, also known as CA-4948 is a potent IRAK4/FLT3 inhibitor with anti-tumor activity. CA-4948 demonstrated good cellular activity in ABC DLBCL and AML cell lines. CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation. Learn More
  15. Leteprinim

    Catalog No. A22613
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    neurotrophic agent
    Leteprinim, also known as AIT-082 and SPI-205, is a neurotrophic agent potentially for the treatment of Alzheimer's disease, and spinal cord injury. Learn More
  16. Blarcamesine (AVex-73)

    Catalog No. A21095
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    muscarinic M1 agonist
    Blarcamesine, also known as AVex-73 and AE-37, is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease. It is an σ receptor ligand. Learn More
  17. Deschloroclozapine

    Catalog No. A20801
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    dual dopamine and serotonin receptor antagonist
    Deschloroclozapine is a dual dopamine and serotonin receptor antagonist with Kis of 200, 2500, 420, 39, 84, 40 nM for dopamine D1, D2,D4, and serotonin S2A, S2C, S3, respectively. Learn More
  18. amyloid P-IN-1

    Catalog No. A20787
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    amyloid P-IN-1 is used in the research of diseases or disorders wherein depletion of serum amyloid P component (SAP), including amyloidosis, Alzheimer's disease, type 2 diabetes mellitus and osteoarthritis. Learn More
  19. TA-1801

    Catalog No. A20729
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    hypolipidemic agent
    TA-1801 is a hypolipidemic agent. Learn More
  20. Azeliragon

    Catalog No. A20622
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    RAGE inhibitor
    Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression in patients with mild Alzheimer??s disease (AD). Azeliragon also can cross the blood-brain barrier (BBB). Learn More
  21. SHP099

    Catalog No. A20594
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    SHP2 inhibitor
    SHP099 is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM. Learn More
  22. Iberin

    Catalog No. A20509
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    Iberin is a sulforaphane homolog and antioxidant. It induces phase II enzyme activity and suppresses CDK expression, inducing apoptosis in cancer cells. Learn More
  23. CCR2 antagonist 3

    Catalog No. A20467
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    CCR2 antagonist
    CCR2 antagonist 3 is a chemokine receptor 2 (CCR2) antagonist. Learn More
  24. LXRβ agonist-2

    Catalog No. A20405
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    LXRβ agonist
    LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis. Learn More
  25. Glutaminyl Cyclase Inhibitor 3

    Catalog No. A20399
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    GC inhibitor
    Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer??s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Learn More
  26. Revizinone

    Catalog No. A20398
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    PDE inhibitor
    Revizinone is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 microM. Learn More
  27. RORγt Inverse agonist 2

    Catalog No. A20243
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    RORγt inverse agonist
    RORγt Inverse agonist 2 is a selective, orally active RORγt inverse agonist with an EC50 of 119 nM. Learn More
  28. TDN345

    Catalog No. A19974
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    Ca2+ antagonist
    TDN345 is a Ca2+ antagonist, used for the treatment of vascular and senile dementia including Alzheimer's disease. Learn More
  29. Fmoc-1,6-diaminohexane

    Catalog No. A19892
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    Fmoc-1,6-diaminohexane is an analog of Osw-1 which can be used to treat Alzheimer's disease and cancer, extracted from patent US 20140135279 A1. Learn More
  30. Alniditan

    Catalog No. A19801
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    5-HT1B/1D receptors agonist
    Alniditan is a potent 5-HT1B/1D receptors agonist, with IC50 of 1.7 and 1.3 nM in HEK?293 cells, and pKi value of 8.96 and 9.40 for 5-HT1B/1D receptors, respectively. Learn More
  31. BMS-986163

    Catalog No. A19770
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    GluN2B modulator
    BMS-986163 is a negative allosteric modulator of GluN2B. The prodrug BMS-986163 rapidly converts to its active parent molecule BMS-986169 (Ki=4 nM, IC50=24 nM). Learn More
  32. ETA antagonist 1

    Catalog No. A19741
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    ETA antagonist
    ETA antagonist 1 is a ETA selective antagonist with an IC50 of 0.08 μM. Learn More
  33. GLN-1062

    Catalog No. A19717
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    GLN-1062 is a pro-drug of galantamine, used for the treatment for Alzheimer??s disease. Learn More
  34. SHIP2-IN-1

    Catalog No. A19650
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    SHIP2 inhibitor
    SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 ?M. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer??s disease. Learn More
  35. 4-(6-Bromo-2-benzothiazolyl)benzenamine

    Catalog No. A19574
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    β-amyloid PET tracer
    4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET (positron emission tomography) tracer that can be used in the diagnosis of neurological diseases, such as Alzheimer's and Down's syndrome. Learn More
  36. BET-IN-4

    Catalog No. A19516
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    BRD4 inhibitor
    BET-IN-4 is a potent BET bromodomain protein (BRD4) inhibitor, with an IC50 of ?? 1 μM. Learn More
  37. Alicapistat

    Catalog No. A19490
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    alpains 1 and 2 inhibitor
    Alicapistat (ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential use in the treatment of Alzheimer's disease (AD). Learn More
  38. Paliroden

    Catalog No. A19323
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    Paliroden is an orally bioactive neurotrophic, non-peptidic compound that activates synthesis of endogenous neurotrophines, used for treatment of Alzheimer's Disease and Parkinson's. Learn More
  39. Elenbecestat

    Catalog No. A19223
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    BACE-1 inhibitor
    Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrant BACE-1 inhibitor for the treatment of Alzheimer's disease (AD). Learn More
  40. YF-2

    Catalog No. A21018
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    histone acetyltransferase activator
    YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease. Learn More
  41. (±)-Huperzine A

    Catalog No. A21003
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    AChE inhibitor
    (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Learn More
  42. PF-06380101

    Catalog No. A21858
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    auristatin microtubule inhibitor
    PF-06380101 (Aur0101), an auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue. Learn More
  43. R 80123

    Catalog No. A21836
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    PDE inhibitor
    R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. Learn More
  44. Thalidomide-O-amido-C3-NH2 (TFA)

    Catalog No. A21801
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    E3 ligase ligand-linker conjugate
    Thalidomide-O-amido-C3-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Learn More
  45. SHP099 hydrochloride

    Catalog No. A21762
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    SHP2 inhibitor
    SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM. Learn More
  46. 42-(2-Tetrazolyl)rapamycin

    Catalog No. A21394
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    mTOR inhibitor
    42-(2-Tetrazolyl)rapamycin is a prodrug compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor. Learn More
  47. MDR-1339

    Catalog No. A21138
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    Aβ-aggregation inhibitor
    MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable Aβ-aggregation inhibitor, used in the research of Alzheimer's disease. Learn More
  48. OICR-0547

    Catalog No. A20877
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    Wdr5-MLL interaction antagonist
    OICR-0547 is a closely related derivative of OICR-9429. OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction, while OICR-0547 cannot bind to WDR5. Learn More
  49. Hydrocortisone buteprate

    Catalog No. A18019
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    Hydrocortisone buteprate (Hydrocortisone probutate) is a medium potent, non-halogenated double-ester of hydrocortisone with a favorable benefit/risk ratio for the treatment of inflammatory skin disorders. Learn More
  50. Niraparib hydrochloride

    Catalog No. A18018
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    PARP1 and PARP2 inhibitor
    Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Learn More

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