Search results for 'betaine hydrochloride'

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  1. BHMT2 Human

    Catalog No. AP4965
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    Betaine-Homocysteine Methyltransferase 2 Human Recombinant Learn More
  2. BHMT Human

    Catalog No. AP4884
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    Betaine Homocysteine S-Methyltransferase Human Recombinant Learn More
  3. BHMT Antibody

    Catalog No. AP2680
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    Betaine Homocysteine S-Methyltransferase, Mouse Anti Human Learn More
  4. Alectinib Hydrochloride

    Catalog No. A18000
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    ALK inhibitor
    Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively. Learn More
  5. GAP-134 Hydrochloride

    Catalog No. A15092
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    Gap-junction modifier
    GAP-134 Hydrochloride, a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability. Learn More
  6. Defactinib hydrochloride

    Catalog No. A22003
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    FAK inhibitor
    Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. Learn More
  7. Nevanimibe hydrochloride

    Catalog No. A21767
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    ACAT1 inhibitor
    Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride) is a selective and potent acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Learn More
  8. Amsacrine hydrochloride

    Catalog No. A17707
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    topoisomerase II inhibitor
    Amsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells. Learn More
  9. TGR-1202 hydrochloride (Umbralisib HCl)

    Catalog No. A16278
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    PI3Kδ inhibitor
    TGR-1202 hydrochloride is an orally available, next generation PI3Kδ inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively. Learn More
  10. LMPTP INHIBITOR 1 dihydrochloride

    Catalog No. A22227
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    LMPTP inhibitor
    LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. Learn More
  11. LYN-1604 dihydrochloride

    Catalog No. A22230
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    ULK1 activator
    LYN-1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC). Learn More
  12. HA-100 dihydrochloride

    Catalog No. A22289
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    PKs inhibitor
    HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50s = 8, 12, and 4 ?M, respectively). Learn More
  13. Iso-H7 dihydrochloride

    Catalog No. A22368
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    inhibitor of phosphokinase C
    Iso-H7 dihydrochloride is an inhibitor of phosphokinase C. Learn More
  14. Quisinostat dihydrochloride

    Catalog No. A22453
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    pan-HDAC inhibitor
    Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity. Learn More
  15. Varenicline HCl

    Catalog No. A22519
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    Varenicline is a nicotinic receptor partial agonist. Learn More
  16. DAPI dihydrochloride

    Catalog No. A22602
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    fluorescent probe
    DAPI Dihydrochloride is a cell-permeable fluorescent probe used to stain DNA and chromosomes, with a preference for adenine and thymine rich DNA. Learn More
  17. IT1t dihydrochloride

    Catalog No. A22027
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    CXCR4 antagonist
    IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. Learn More
  18. PAβN dihydrochloride

    Catalog No. A22016
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    efflux pump inhibitor
    PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor. Learn More
  19. IT1t

    Catalog No. A20408
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    CXCR4 antagonist
    IT1t is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. Learn More
  20. SB-772077B dihydrochloride

    Catalog No. A20090
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    ROCK inhibitor
    SB-772077B dihydrochloride is an aminofurazan-based Rho kinase (ROCK) inhibitor with IC50s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively. Learn More
  21. XE 991 dihydrochloride

    Catalog No. A20032
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    Kv7 (KCNQ) channels blocker
    XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 ?M, 0.71 ?M, 0.6 μM, and 0.98 ?M, respectively. Learn More
  22. AZ10606120 dihydrochloride

    Catalog No. A19853
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    P2X7R antagonist
    AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10?nM. Learn More
  23. Dianicline dihydrochloride

    Catalog No. A19775
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    α4β2 nicotinic acetylcholine receptor partial agonist
    Dianicline dihydrochloride is a α4β2 nicotinic acetylcholine receptor partial agonist, a class of drugs that includes varenicline and cytisine for smoking cessation. Learn More
  24. ABT-702 dihydrochloride

    Catalog No. A19624
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    AK inhibitor
    ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor (IC50=1.7 nM). Learn More
  25. Aminooxyacetic acid hemihydrochloride

    Catalog No. A19408
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    MAS inhibitor
    Aminooxyacetic acid hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T. Learn More
  26. Hydroquinine

    Catalog No. A17533
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    Hydroquinine is a cinchona alkaloid, can be used in the preparation of its derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine and 10,11-dihydroquinine monohydrochloride. Learn More
  27. N-Desethyl amodiaquine dihydrochloride

    Catalog No. A21695
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    N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. Learn More
  28. d-Atabrine dihydrochloride

    Catalog No. A21654
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    d-Atabrine dihydrochloride is an active enantiomer of quinacrine which displays antiprion activity. Learn More
  29. Banoxantrone D12 dihydrochloride

    Catalog No. A21438
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    Banoxantrone D12 dihydrochloride (AQ4N D12 dihydrochloride) is the deuterium labeled banoxantrone dihydrochloride. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. Learn More
  30. Banoxantrone dihydrochloride

    Catalog No. A21432
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    Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. Learn More
  31. Veliparib dihydrochloride

    Catalog No. A21356
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    PARP inhibitor
    Veliparib dihydrochloride is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively. Learn More
  32. Ro 10-5824 dihydrochloride

    Catalog No. A21986
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    dopamine D4 receptor partial agonist
    Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM. Learn More
  33. LDN193189 Tetrahydrochloride

    Catalog No. A21881
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    BMP type I receptor inhibitor
    LDN193189 Tetrahydrochloride is a selective BMP type I receptor inhibitor, which efficiently inhibits ALK2 and ALK3 (IC50=5 nM and 30 nM, respectively), with weaker effects on ALK4, ALK5 and ALK7 (IC50??500 nM). Learn More
  34. MW-150 dihydrochloride dihydrate

    Catalog No. A21860
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    p38α MAPK inhibitor
    MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. Learn More
  35. Liarozole dihydrochloride

    Catalog No. A21853
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    CYP450 dependent inhibitor
    Liarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase). Learn More
  36. B-Raf inhibitor 1 dihydrochloride

    Catalog No. A21834
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    Raf kinase inhibitor
    B-Raf inhibitor 1 dihydrochloride is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively. Learn More
  37. GSK-LSD1 dihydrochloride

    Catalog No. A21815
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    LSD1 inhibitor
    GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM. Learn More
  38. DDR1-IN-1 dihydrochloride

    Catalog No. A21813
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    DDR1 receptor tyrosine kinase inhibitor
    DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM). Learn More
  39. Lexibulin dihydrochloride

    Catalog No. A21774
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    tubulin polymerisation inhibitor
    Lexibulin 2Hcl (CYT-997 2Hcl) is a potent tubulin polymerisation inhibitor with IC50 of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Learn More
  40. K-604 dihydrochloride

    Catalog No. A21773
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    ACAT-1 inhibitor
    K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45??0.06 μM. Learn More
  41. Philanthotoxin 74 dihydrochloride

    Catalog No. A21739
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    AMPAR antagonist
    Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. Learn More
  42. Ipatasertib dihydrochloride

    Catalog No. A21734
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    pan-Akt inhibitor
    Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA. Learn More
  43. GSK3368715 dihydrochloride

    Catalog No. A21733
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    PRMT inhibitor
    GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). Learn More
  44. MCOPPB triHydrochloride

    Catalog No. A21722
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    nociceptin receptor agonist
    MCOPPB 3Hcl is a nociceptin receptor agonist with pKi of 10.07; weaker activity at other opioid receptors. Learn More
  45. N8-Acetylspermidine dihydrochloride

    Catalog No. A21720
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    N8-Acetylspermidine dihydrochloride is a polyamine. Learn More
  46. Lys01 trihydrochloride

    Catalog No. A21702
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    lysosomal autophagy inhibitor
    Lys01 trihydrochloride (Lys05) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay. Learn More
  47. TLR7/8 agonist 1 dihydrochloride

    Catalog No. A21700
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    TLR7/8 agonist
    TLR7/8 agonist 1 dihydrochloride is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline. Learn More
  48. diABZI STING agonist-1 trihydrochloride

    Catalog No. A21694
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    STING receptor agonist
    diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with an EC50s of 130 for human PBMCs. Learn More
  49. LCL521 dihydrochloride

    Catalog No. A21656
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    ACDase inhibitor
    LCL521 dihydrochloride (1,3DMG-B13 dihydrochloride) is an acid ceramidase (ACDase) inhibitor. Learn More
  50. MRT68921 dihydrochloride

    Catalog No. A21650
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    ULK1/ULK2 inhibitor
    MRT68921 dihydrochloride is the most potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively. Learn More

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