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  1. Ombrabulin hydrochloride

    Catalog No. A21040
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    Ombrabulin hydrochloride is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells. Learn More
  2. ARC Human

    Catalog No. AP0609
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    Activity-Regulated Cytoskeleton-Associated Protein Human Recombinant Learn More
  3. i-Inositol

    Catalog No. A16010
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    i-Inositol is a chemical compound which is sugar alcohol. i-Inositol is involved in a number of biological processes including insulin signal transduction, cytoskeleton transduction and so on. Learn More
  4. API-1

    Catalog No. A22093
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    Akt inhibitor
    API-1 (NSC 177223) is a potent inhibitor of Akt that induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis. Learn More
  5. MN58b

    Catalog No. A22129
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    choline kinase α (CHKα) inhibitor
    MN58b is a selective choline kinase α (CHKα) inhibitor, and results in inhibition of phosphocholine synthesis. Learn More
  6. CC-92480

    Catalog No. A22433
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    antimyeloma agent
    CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD). CC-92480 shows high affinity to cereblon, resulting in potent antimyeloma activity. Learn More
  7. LP-261

    Catalog No. A22487
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    LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest. Screening in the NCI60 cancer cell lines resulted in a mean GI50 of approximately 100 nM. Learn More
  8. Ro-24-0238

    Catalog No. A20719
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    thromboxane synthesis inhibitor
    Ro-24-0238 is an antagonist of platelet activating factor (PAF) and inhibitor of thromboxane synthesis, used for lessening the inflammation and damage resulting from a local release of PAF. Learn More
  9. Acridine Orange hydrochloride

    Catalog No. A19835
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    fluorescent dye
    Acridine Orange hydrochloride is a cell-permeable fluorescent dye that binds to nucleic acids, resulting in an altered spectral emission. Learn More
  10. ARN2966

    Catalog No. A21016
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    APP expression modulator
    ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. Learn More
  11. Tasisulam sodium

    Catalog No. A21456
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    Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Learn More
  12. Dapagliflozin ((2S)-1,2-propanediol, hydrate)

    Catalog No. A17687
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    SGLT2 inhibitor
    Dapagliflozin ((2S)-1,2-propanediol, hydrate), a new type of drug used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine. Learn More
  13. SS28

    Catalog No. A12170
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    SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin. Learn More
  14. PTC299

    Catalog No. A18935
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    VEGFA inhibitor
    PTC299 is a potent, orally bioavailable VEGFA inhibitor, targets dihydroorotate dehydrogenase (DHODH), resulting in cell growth inhibition and differentiation in leukemias, including acute myeloid leukemia, linking DHODH regulation and stress-induced VEGFA and angiogenesis. Learn More
  15. SEC inhibitor KL-2

    Catalog No. A19043
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    SEC inhibitor
    SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. Learn More
  16. Cholestyramine

    Catalog No. A18230
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    Cholestyramine (Colestyramine) is a bile acid binding resin and can inhibit intestinal bile acid absorption which results in the increasing bile acid synthesis from cholesterol. Learn More
  17. TH5487

    Catalog No. A18537
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    OGG1 inhibitor
    TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes. Learn More
  18. CCI-006

    Catalog No. A18587
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    CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells. Learn More
  19. Propofol

    Catalog No. A18293
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    Propofol is a hypnotic alkylphenol derivative. Propofol is a General Anesthetic. Propofol is a short-acting medication that results in a decreased level of consciousness and lack of memory for events. Formulated for intravenous induction of sedation and hypnosis during anesthesia, propofol facilitates inhibitory neurotransmission mediated by gamma-aminobutyric acid (GABA). Learn More
  20. Chlorhexidine digluconate

    Catalog No. A18123
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    broad spectrum antibiotic
    Chlorhexidine digluconate solution is a bis-biguanide family cationic broad spectrum antibiotic. Studies indicate that chlorhexidine digluconate solution functions, via destabilization of the outer bacterial membrane, which resulted in the release of periplasmic enzymes in gram negative bacteria. Learn More
  21. Dydrogesterone

    Catalog No. A18112
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    Dydrogesterone is a synthetic progestin. Dydrogesterone alone or in combination with estrogen to endothelial cells results in neutral effects on NO synthesis and on the activity and expression of eNOS. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation. Learn More
  22. Cinchocaine

    Catalog No. A17672
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    Dibucaine (USAN) is an amide local anesthetic. Dibucaine reversibly binds to and inactivates sodium channels in the neuronal cell membrane. Inhibition of sodium channels prevents the depolarization of nerve cell membranes and inhibits subsequent propagation of impulses along the course of the nerve, thereby limiting the excitation of nerve endings. This results in loss of sensation. Learn More
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    KL1333

    Catalog No. A17234
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    NAD+ Modulator
    KL1333 is an orally available, small organic molecule that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL-1333 Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. Learn More
  23. Cefamandole nafate

    Catalog No. A17263
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    Cefamandole nafate is a pro-drug that is hydrolyzed by plasma esterases to produce cefamandole, second-generation cephalosporin antibiotic with bactericidal activity. Cefamandole nafate is used to study the effects of expression and inhibition of PBP 2A and other penicillin-binding proteins (PDPs) on bacterial cell wall mucopeptide synthesis. Cefamandole binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Learn More
  24. Chlorthalidone

    Catalog No. A17253
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    Chlorthalidone is a diuretic drug used to treat hypertension. It is described as a thiazide diuretic. Compared with other medications of the thiazide class, chlortalidone has the longest duration of action but a similar diuretic effect at maximal therapeutic doses. Chlortalidone is often used in the management of hypertension and edema. Chlorthalidone directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment in the distal convoluted tubule in the kidney. This leads to an increase in sodium, chloride, bicarbonate, and potassium secretion resulting in the excretion of water. Learn More
  25. TX1-85-1

    Catalog No. A16361
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    Her3 (ErbB3) ligand
    TX1-85-1 is ErbB3 inhibitor. TX2-121-1 may exert Her3-dependent pharmacology through an allosteric mechanismthereby disrupting interactions between Her3 and other proteins such as Her3 or cMet consistent with results presented here and distinct from conventional kinase inhibitors, which block catalytic function. Learn More
  26. Cytochalasin H

    Catalog No. A16088
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    Cytochalasin H is used in actin polymerization studies. Cytochalasins are potent mycotoxins which bind to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Used as a tool for cytological research. Learn More
  27. DC_AC50

    Catalog No. A16043
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    Atox1/CCS inhibitor
    DC_AC50 is an inhibitor of copper trafficking proteins Atox1 and CCS, resulting in a disruption of cellular copper transport. Learn More
  28. 2-MPPA

    Catalog No. A12809
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    GCP-II inhibitor
    2-MPPA is a selective glutamate carboxypeptidase II (GCP-II) inhibitor used in the treatment of neurological disorders associated with excessive activation of glutamatergic systems. Attenuates glutamate transmission resulting in the relief of neuropathic pain. Learn More
  29. Etoricoxib

    Catalog No. A13770
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    COX-2 inhibitor
    Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. Learn More
  30. Clasto-Lactacystin b-lactone

    Catalog No. A15427
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    20S proteasome inhibitor
    Clasto-lactacystin b-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive b-lactone. Learn More
  31. AM 114

    Catalog No. A14922
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    20S proteasome inhibitor
    AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins. Learn More
  32. SCR7

    Catalog No. A15447
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    DNA ligase IV inhibitor
    SCR7 is a specific DNA Ligase IV inhibitor. SCR7 inhibits end joining of double strand breaks in diverse cell types resulting in tumour regression by activation of p53 mediated apoptosis. Learn More
  33. PTC-209 HBr

    Catalog No. A14280
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    BMI-1 inhibitor

    PTC-209 HBr is the hydrobromide salt of PTC-209PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of cancer-initiating cells (CICs).

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  34. Tedalinab

    Catalog No. A14189
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    CB2 receptor agonist
    Tedalinab (GRC-10693) is a drug developed for the treatment of osteoarthritis and neuropathic pain, which acts as a potent and selective cannabinoid CB2 receptor agonist. It has a very high selectivity of 4700x for CB2 over the related CB1 receptor, has good oral bioavailability and has shown promising safety results and effective analgesic and antiinflammatory actions in early clinical trials. Learn More
  35. ANX-510

    Catalog No. A12370
    ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity. Learn More
  36. Pitavastatin calcium (Livalo)

    Catalog No. A10737
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    HMG-CoA reductase inhibitor
    Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Learn More
  37. Dobutamine hydrochloride

    Catalog No. A10325
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    Adrenoceptors agonist
    Dobutamine is a direct-acting agent whose primary activity results from stimulation of the β1-adrenoceptors of the heart, increasing contractility and cardiac output. Learn More
  38. Bryostatin 1

    Catalog No. A10261
    PKC inhibitor
    Bryostatin 1 is a macrolactone isolated from the marine bryozoan, Bugula neritina, that modulates protein kinase C (PKC) activity. Bryostain 1 induces an initial rapid activation and autophosphorylation of PKC that results in the translocation of the PKC enzyme to the membrane. Learn More
  39. Strontium ranelate (Protelos)

    Catalog No. A11681
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    CaSR agonist
    Strontium ranelate is an antiosteoporotic agent which both increases bone formation and reduces bone resorption, resulting in a rebalance of bone turnover in favor of bone formation. This is similar to the effects of choline stabilized orthosilicic acid. Learn More
  40. Balofloxacin

    Catalog No. A11658
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    Topoisomerase inhibitor
    Balofloxacin is a quinolone antibiotic. The bactericidal action of Balofloxacin results from interference with the enqyme DNA gyrase which is needed for the synthesis of bacterial DNA. Balofloxacin is efficacious against Gram-negative bacteria. It also has enhanced activity against Gram positive bacteria, including MRSA and Streptococcus pneumoniae. Learn More
  41. LY2140023 (LY404039)

    Catalog No. A10544
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    mGluR Agonist
    LY-404039 is a drug used in scientific research that acts as a selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. It has anxiolytic and antipsychotic effects in animal studies, but without causing sedation. Early human trials using a prodrug form of LY-404,039 called LY-214,0023 have also given encouraging results. Learn More
  42. CYC116 (CYC-116)

    Catalog No. A10248
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    Aurora Kinase inhibitor
    Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. Learn More
  43. Ritonavir

    Catalog No. A10799
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    HIV Protease inhibitor
    Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease.Ritonavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. Learn More
  44. NXY-059 (Cerovive)

    Catalog No. A10663
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    Free radical trapping agent
    NXY-059 is the disulfonyl derivative of the neuroprotective spin trap pheny lbutynitrone or "PBN" with free radical-trapping properties. It substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Learn More
  45. Nelarabine (Arranon)

    Catalog No. A10632
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    Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity. Learn More
  46. Cetaben

    Catalog No. A11137
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    Peroxisome Proliferator
    Cetaben is a unique, PPARα-independent peroxisome proliferator with hypolipidemic activity that inhibits cholesterol synthesis in the human hepatoma Hep-G2 cells resulting in reversible changes in Golgi morphology. Learn More
  47. CP-466722

    Catalog No. A11086
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    ATM inhibitor
    CP-466722 is a specific ATM inhibitor that inhibits cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Learn More
  48. HMN-214

    Catalog No. A10452
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    PLK Inhibitor
    HMN-214 inhibits polo-like and cyclin-dependent kinase activity, has potent antimicrotubular effects and results in profound apoptosis and antitumor activity in a broad spectrum of human xenografts. Learn More
  49. Arry-380 analog

    Catalog No. A11027
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    HER2 Inhibitor
    ARRY-380 is an ErbB-2 inhibitor that selectively binds to and inhibits the phosphorylation of ErbB-2, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. Learn More

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