Search results for 'ff 10101'

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  1. Liothyronine sodium

    Catalog No. A20353
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    Liothyronine sodium is a thyroid hormone (T3) analog. It promotes adipogenic differentiation of MSCs. Learn More
  2. Emedastine

    Catalog No. A22158
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    histamine H1 receptor antagonist
    Emedastine is an orally active, selective and high affinity histamine H1 receptor antagonist with a Ki value of 1.3 nM. Learn More
  3. Gentiopicroside

    Catalog No. A22172
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    antianti-inflammatoryand antioxidative effects
    Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 ?M and 22.8 ?M for CYP2A6; Gentiopicroside has antianti-inflammatoryand antioxidative effects. Learn More
  4. Eleutheroside B1

    Catalog No. A22173
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    anti-human influenza virus efficacy
    Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50 value of 64-125 ?g/ml. Antiviral and anti-inflammatory activities. Learn More
  5. Periplogenin

    Catalog No. A22174
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    anti-psoriatic agent
    Periplogenin is a naturally occurring furanocoumarin found in Angelica dahurica roots, with potent anti-psoriatic effects. Periplogenin induces adipocyte differentiation. Learn More
  6. Groenlandicine

    Catalog No. A22176
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    protoberberine alkaloid
    Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR). Learn More
  7. SBP-7455

    Catalog No. A22209
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    dual ULK1/ULK2 autophagy inhibitor
    SBP-7455 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. Learn More
  8. S29434

    Catalog No. A22217
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    inhibitor of quinone reductase 2 (QR2)
    S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. Learn More
  9. LY2828360

    Catalog No. A22228
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    cannabinoid (CB2) agonist
    LY2828360 is a slowly acting but efficacious G protein-biased cannabinoid (CB2) agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling. Learn More
  10. Imidazenil

    Catalog No. A22247
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    GABA-A modulator
    Imidazenil is a GABA-A modulator that blocks the sedative effects without lowering the convulsion threshold. Learn More
  11. (R)-Propranolol hydrochloride

    Catalog No. A22258
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    β-adrenergic receptor (βAR) antagonist
    (R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Learn More
  12. Enocyanin

    Catalog No. A18660
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    anthocyanin extracted from grapes
    Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity. Learn More
  13. KGA-2727

    Catalog No. A22062
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    SGLT1 inhibitor
    KGA-2727 is a first selective, high-affinity and orally active SGLT1 inhibitor with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. Learn More
  14. CYM50308

    Catalog No. A22072
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    sphingosine-1-phosphate receptor 4 (S1P4-R) agonist
    CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. Learn More
  15. PF9601N

    Catalog No. A22075
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    monoamine oxidase B inhibitor
    PF9601N is a selective and potent monoamine oxidase B inhibitor that exhibit anti-Parkinsonian effects in several models of PD. Learn More
  16. RBC10

    Catalog No. A22098
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    inhibitor of Ral binding to RALBP1
    RBC10 is an inhibitor of Ral binding to RALBP1 (the effector). Learn More
  17. NIBR-0213

    Catalog No. A22099
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    S1P(1) antagonist
    NIBR-0213 is a potent and selective antagonist of S1P(1) with efficacy in experimental autoimmune encephalomyelitis. Learn More
  18. FLTX1

    Catalog No. A22120
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    antiestrogenic properties
    FLTX1 is a fluorescent Tamoxifen derivative that can specifically label intracellular Tamoxifen-binding sites (estrogen receptors) under permeabilized and non-permeabilized conditions. FLTX1 exhibits the potent antiestrogenic properties of Tamoxifen in breast cancer cells. FLTX1 is devoid of the estrogenic agonistic effect on the uterus. Learn More
  19. Epiblastin A

    Catalog No. A22121
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    inhibitor of Casein Kinase 1 (CK1)
    Epiblastin A is an inhibitor of Casein Kinase 1 (CK1) that engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells (EpiSCs) into embryonic stem cells (cESCs). Learn More
  20. MSA-2

    Catalog No. A22139
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    non-nucleotide STING agonist
    MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. Learn More
  21. WWL229

    Catalog No. A22149
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    Ces3 inhibitor
    WWL229 is a selective inhibitor of Ces3 that acts by inhibiting recombinant Ces3 and recapitulating the effects of WWL113 in adipocytes. Learn More
  22. ERDRP-0519

    Catalog No. A22150
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    inhibitor of polymerase
    ERDRP-0519 is an orally available inhibitor of polymerase that shows efficacy against a lethal morbillivirus infection in a large animal model. Learn More
  23. RGD peptide (GRGDNP)

    Catalog No. A22271
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    integrin-ligand interactions inhibitor
    RGD peptide (GRGDNP) acts as an inhibitor of integrin-ligand interactions and plays an important role in cell adhesion, migration, growth, and differentiation. Learn More
  24. AUNP-12

    Catalog No. A22274
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    peptide antagonist
    AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. Learn More
  25. MLS000532223

    Catalog No. A22285
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    Rho family GTPases inhibitor
    MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 values ranging from 16 μM to 120 μM. Learn More
  26. Urolithin B

    Catalog No. A22287
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    regulator of skeletal muscle mass
    Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B is also a regulator of skeletal muscle mass. Learn More
  27. 3-Hydroxyanthranilic acid

    Catalog No. A22292
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    immunomodulatory agent
    3-Hydroxyanthranilic Acid (3-HAA, 3-HANA), a tryptophan metabolite, has an immunomodulatory effect that may result from inhibition of PI3K/Akt/mTOR and NF-κB activity, thereby decreasing the production of pro-inflammatory mediators. Learn More
  28. SC-43

    Catalog No. A22295
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    SHP-1 (PTPN6) agonist
    SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects. Learn More
  29. BD750

    Catalog No. A22300
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    JAK3/STAT5 inhibitor
    BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively. Learn More
  30. Kaempferol 3-neohesperidoside

    Catalog No. A22314
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    Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) is a flavonoid. Kaempferol 3-neohesperidoside exhibits insulinomimetic effect on the rat soleus muscle. Learn More
  31. 3'-Hydroxypterostilbene

    Catalog No. A22341
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    natural pterostilbene analogue
    3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. Learn More
  32. Dihydrocaffeic acid

    Catalog No. A22344
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    Antioxidant agent
    Dihydrocaffeic acid is a phenolic acid found in Gynura bicolor, reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Antioxidant potential and anti-inflammatory activity. Learn More
  33. Pyridoxine

    Catalog No. A22350
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    antioxidant agent
    Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. Learn More
  34. Nootkatone

    Catalog No. A22352
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    neuroprotective agent
    Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects. Learn More
  35. Beta-asarone

    Catalog No. A22354
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    neuroprotection agent
    Beta-Asarone, found in certain plants such as Acorus and Asarum, could pass the blood-brain barrier and exerts neuroprotection effects. Learn More
  36. Skatole

    Catalog No. A22359
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    bacteriostatic agent
    Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.. Learn More
  37. TP0427736 HCl

    Catalog No. A22382
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    ALK5 kinase activity inhibitor
    TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. Learn More
  38. Gambogenic acid

    Catalog No. A22383
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    EZH2 inhibitor
    Gambogenic acid is an active ingredient in gamboge, with anticancer activity. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination. Learn More
  39. (±)-Praeruptorin A

    Catalog No. A22384
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    traditional Chinese medicines
    (±)-Praeruptorin A is the di-esterified product of cis-khellactone (CKL) and the major active ingredient in Peucedani Radix which consists of the dried roots of Peucedanum praeruptorumDunn (Apiaceae). (±)-Praeruptorin A has been widely employed as one of the famous traditional Chinese medicines (TCMs) for the treatment of cough with thick sputum and dyspnea, nonproductive cough and upper respiratory infections for centuries in China. (±)-Praeruptorin A has dramatically therapeutic effects on hypertension mainly through acting as a Ca2+-influx blocker. Learn More
  40. Erucic acid

    Catalog No. A22389
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    monounsaturated fatty acid
    Erucic acid, a monounsaturated fatty acid (MUFA), is isolated from the seed of Raphanus sativus L. Erucic acid can readily cross the blood-brain barrier (BBB), it has been reported to normalize the accumulation of very long-chain fatty acids in the brain. Erucic acid can improve cognitive impairment and be effective against dementia . Learn More
  41. 2,3-Butanedione-2-monoxime

    Catalog No. A22395
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    inhibitor of skeletal muscle myosin-II
    2,3-Butanedione monoxime (BDM, Diacetyl monoxime, Diacetylmonoxime) is the well-characterized, low-affinity, non-competitive inhibitor of skeletal muscle myosin-II and inhibits skeletal and cardiac muscle contraction. Learn More
  42. Incensole Acetate

    Catalog No. A22402
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    neuroprotective agent
    Incensole acetate is a main constituent of Boswellia carterii resin, has neuroprotective effects against neuronal damage in traumatic and ischemic head injury. Incensole acetate reduces Aβ25?C35-triggered apoptosis in hOBNSCs. Learn More
  43. β-Elemonic acid

    Catalog No. A22403
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    anti?inflammatory agent
    Beta-Elemonic acid (3-Oxotirucallenoic Acid), a known triterpene isolated from Boswellia (Burseraceae), exhibits anti?inflammatory effects. Learn More
  44. 5,?7,?4'-?Trimethoxyflavone

    Catalog No. A22408
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    anticancer agent
    5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner. Learn More
  45. ML162

    Catalog No. A22418
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    GPX4 inhibitor
    ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines. Learn More
  46. ODQ

    Catalog No. A22420
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    soluble guanylyl cyclase inhibitor
    ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells. Learn More
  47. S-Allyl-L-cysteine

    Catalog No. A22422
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    anti-cancer agent
    S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity. Learn More
  48. Rosamultin

    Catalog No. A22429
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    antioxidant agent
    Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. Rosamultin has inhibitory effects against HIV-1 protease. Rosamultin has the potential for treating H2O2-induced oxidative stress injury through its antioxidant and antiapoptosis effects. Learn More
  49. CC-92480

    Catalog No. A22433
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    antimyeloma agent
    CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD). CC-92480 shows high affinity to cereblon, resulting in potent antimyeloma activity. Learn More
  50. PHY34

    Catalog No. A22434
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    late-stage autophagy inhibitor
    PHY34 is a late-stage autophagy inhibitor with nanomolar potency and significant antitumor efficacy as a single agent against HGSOC in vivo. Learn More

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