Search results for 'flurazepam dihydrochloride'

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  1. PAβN dihydrochloride

    Catalog No. A22016
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    efflux pump inhibitor
    PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor. Learn More
  2. Banoxantrone D12 dihydrochloride

    Catalog No. A21438
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    Banoxantrone D12 dihydrochloride (AQ4N D12 dihydrochloride) is the deuterium labeled banoxantrone dihydrochloride. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. Learn More
  3. Ipatasertib dihydrochloride

    Catalog No. A21734
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    pan-Akt inhibitor
    Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA. Learn More
  4. GDC-0575 dihydrochloride

    Catalog No. A21567
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    CHK1 inhibitor
    GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity. Learn More
  5. GSK3368715 dihydrochloride

    Catalog No. A21733
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    PRMT inhibitor
    GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). Learn More
  6. LCL521 dihydrochloride

    Catalog No. A21656
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    ACDase inhibitor
    LCL521 dihydrochloride (1,3DMG-B13 dihydrochloride) is an acid ceramidase (ACDase) inhibitor. Learn More
  7. Lerociclib dihydrochloride

    Catalog No. A21577
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    CDK4/CDK6 inhibitor
    Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. Learn More
  8. NVP-BSK805 dihydrochloride

    Catalog No. A21406
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    JAK2 inhibitor
    NVP-BSK805 dihydrochloride (BSK805 dihydrochloride) is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively. Learn More
  9. Mirodenafil dihydrochloride

    Catalog No. A18047
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    PDE-5 inhibitor
    Mirodenafil dihydrochloride (SK3530 dihydrochloride) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. Learn More
  10. Canertinib dihydrochloride

    Catalog No. A11344
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    EGFR inhibitor
    Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Learn More
  11. Retigabine dihydrochloride

    Catalog No. A15222
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    KCNQ channel opener
    Retigabine dihydrochloride is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity. Learn More
  12. LDK378 (Ceritinib) dihydrochloride

    Catalog No. A15142
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    ALK inhibitor
    LDK378 dihydrochloride is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively. Learn More
  13. Banoxantrone dihydrochloride

    Catalog No. A21432
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    Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. Learn More
  14. MW-150 dihydrochloride dihydrate

    Catalog No. A21860
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    p38α MAPK inhibitor
    MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. Learn More
  15. Liarozole dihydrochloride

    Catalog No. A21853
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    CYP450 dependent inhibitor
    Liarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase). Learn More
  16. Philanthotoxin 74 dihydrochloride

    Catalog No. A21739
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    AMPAR antagonist
    Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. Learn More
  17. SB-277011 dihydrochloride

    Catalog No. A21353
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    dopamine D3 receptor antagonist
    SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively. Learn More
  18. Azaphen dihydrochloride monohydrate

    Catalog No. A15009
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    serotonin reuptake inhibitor
    Azaphen is a potent inhibitor of the reuptake of serotonin. Learn More
  19. LY2801653 dihydrochloride

    Catalog No. A15150
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    MET inhibitor
    LY2801653 dihydrochloride is a potent, orally bioavailable, small-molecule inhibitor of c-MET kinase(Ki= 2 nM). Learn More
  20. H-1152 dihydrochloride

    Catalog No. A15102
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    ROCK inhibitor
    H-1152 dihydrochloride, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. Learn More
  21. IT1t dihydrochloride

    Catalog No. A22027
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    CXCR4 antagonist
    IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. Learn More
  22. SB-772077B dihydrochloride

    Catalog No. A20090
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    ROCK inhibitor
    SB-772077B dihydrochloride is an aminofurazan-based Rho kinase (ROCK) inhibitor with IC50s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively. Learn More
  23. ABT-702 dihydrochloride

    Catalog No. A19624
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    AK inhibitor
    ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor (IC50=1.7 nM). Learn More
  24. N-Desethyl amodiaquine dihydrochloride

    Catalog No. A21695
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    N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. Learn More
  25. d-Atabrine dihydrochloride

    Catalog No. A21654
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    d-Atabrine dihydrochloride is an active enantiomer of quinacrine which displays antiprion activity. Learn More
  26. Veliparib dihydrochloride

    Catalog No. A21356
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    PARP inhibitor
    Veliparib dihydrochloride is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively. Learn More
  27. Ro 10-5824 dihydrochloride

    Catalog No. A21986
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    dopamine D4 receptor partial agonist
    Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM. Learn More
  28. GSK-LSD1 dihydrochloride

    Catalog No. A21815
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    LSD1 inhibitor
    GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM. Learn More
  29. K-604 dihydrochloride

    Catalog No. A21773
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    ACAT-1 inhibitor
    K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45??0.06 μM. Learn More
  30. N8-Acetylspermidine dihydrochloride

    Catalog No. A21720
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    N8-Acetylspermidine dihydrochloride is a polyamine. Learn More
  31. TLR7/8 agonist 1 dihydrochloride

    Catalog No. A21700
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    TLR7/8 agonist
    TLR7/8 agonist 1 dihydrochloride is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline. Learn More
  32. MRT68921 dihydrochloride

    Catalog No. A21650
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    ULK1/ULK2 inhibitor
    MRT68921 dihydrochloride is the most potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively. Learn More
  33. l-Atabrine dihydrochloride

    Catalog No. A21646
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    l-Atabrine dihydrochloride is a less active enantiomer of quinacrine which displays antiprion activity. Learn More
  34. JNJ-37822681 dihydrochloride

    Catalog No. A21470
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    dopamine D2 receptor antagonist
    JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder. Learn More
  35. PF429242 dihydrochloride

    Catalog No. A21386
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    S1P inhibitor
    PF429242 dihydrochloride is a reversible and competitive S1P inhibitor with an IC50 of 175 nM. Learn More
  36. JDTic dihydrochloride

    Catalog No. A11469
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    KOR antagonist
    JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception. Learn More
  37. Lesopitron dihydrochloride

    Catalog No. A12950
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    5-HT1A receptor agonist
    Lesopitron dihydrochloride is a full and selective 5-HT1A receptor agonist with IC50 of 125 nM in rat hippocampal membranes. Learn More
  38. AQ-13 dihydrochloride

    Catalog No. A12178
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    AQ-13 dihydrochloride is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum. Learn More
  39. Ranolazine dihydrochloride

    Catalog No. A10781
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    Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Learn More
  40. L-NIO dihydrochloride

    Catalog No. A13027
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    NOS inhibitor
    L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor. Learn More
  41. Levocetirizine Dihydrochloride

    Catalog No. A17440
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    Histamine H1 receptor antagonist
    Levocetirizine dihydrochloride is a L-isomer of cetirizine and histamine H1 receptor antagonist. It incrases levels of CD4+ CD25+ T cells and decreases levels of eosinophils, decreasing allergy symptoms. Learn More
  42. UAMC 00039 dihydrochloride

    Catalog No. A16047
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    DPP-II inhibitor
    UAMC 00039 dihydrochloride is a potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50 = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC50 values are 78.6, 142 and 165 μM, respectively). Learn More
  43. ML 786 dihydrochloride

    Catalog No. A11211
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    Raf inhibitor
    ML 786 dihydrochloride is a potent Raf kinase inhibitor (IC50 values are 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf respectively). Learn More
  44. SKF 86002 Dihydrochloride

    Catalog No. A11101
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    p38 MAPK inhibitor
    SKF 86002 Dihydrochloride is inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 uM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 uM). Learn More
  45. AT7867 2HCl

    Catalog No. A15006
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    Akt inhibitor
    AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family. Learn More
  46. Dexpramipexole dihydrochloride

    Catalog No. A15066
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    dopamine agonist
    Dexpramipexole dihydrochloride is a neuroprotective agent and weak non-ergoline dopamine agonist. Learn More
  47. cis-(Z)-Flupentixol dihydrochloride

    Catalog No. A12347
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    Dopamine receptor antagonist
    cis-(Z)-Flupentixol dihydrochloride is a dopamine receptor antagonist, antipsychotic, neuroleptic agent. Learn More
  48. 1400W Dihydrochloride

    Catalog No. A13583
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    INOS inhibitor
    1400W Dihydrochloride is a slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). Selective over nNOS and eNOS (Ki values are 2 and 50 μM respectively). Cell-permeable and active in vivo. Learn More
  49. E-4031 dihydrochloride

    Catalog No. A12857
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    K+ channel blocker‎
    E-4031 dihydrochloride is a selective blocker of KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Learn More
  50. SR 3677 dihydrochloride

    Catalog No. A12674
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    ROCK inhibitor
    SR 3677 dihydrochloride is a potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively). Learn More

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