Search results for 'flurazepam dihydrochloride'

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  1. Quisinostat dihydrochloride

    Catalog No. A22453
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    pan-HDAC inhibitor
    Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity. Learn More
  2. GSK3368715 dihydrochloride

    Catalog No. A21733
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    PRMT inhibitor
    GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). Learn More
  3. LCL521 dihydrochloride

    Catalog No. A21656
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    ACDase inhibitor
    LCL521 dihydrochloride (1,3DMG-B13 dihydrochloride) is an acid ceramidase (ACDase) inhibitor. Learn More
  4. Lerociclib dihydrochloride

    Catalog No. A21577
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    CDK4/CDK6 inhibitor
    Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. Learn More
  5. NVP-BSK805 dihydrochloride

    Catalog No. A21406
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    JAK2 inhibitor
    NVP-BSK805 dihydrochloride (BSK805 dihydrochloride) is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively. Learn More
  6. Mirodenafil dihydrochloride

    Catalog No. A18047
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    PDE-5 inhibitor
    Mirodenafil dihydrochloride (SK3530 dihydrochloride) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. Learn More
  7. Canertinib dihydrochloride

    Catalog No. A11344
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    EGFR inhibitor
    Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Learn More
  8. Retigabine dihydrochloride

    Catalog No. A15222
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    KCNQ channel opener
    Retigabine dihydrochloride is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity. Learn More
  9. LDK378 (Ceritinib) dihydrochloride

    Catalog No. A15142
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    ALK inhibitor
    LDK378 dihydrochloride is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively. Learn More
  10. PAβN dihydrochloride

    Catalog No. A22016
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    efflux pump inhibitor
    PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor. Learn More
  11. Banoxantrone D12 dihydrochloride

    Catalog No. A21438
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    Banoxantrone D12 dihydrochloride (AQ4N D12 dihydrochloride) is the deuterium labeled banoxantrone dihydrochloride. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. Learn More
  12. Ipatasertib dihydrochloride

    Catalog No. A21734
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    pan-Akt inhibitor
    Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA. Learn More
  13. GDC-0575 dihydrochloride

    Catalog No. A21567
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    CHK1 inhibitor
    GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity. Learn More
  14. DAPI dihydrochloride

    Catalog No. A22602
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    fluorescent probe
    DAPI Dihydrochloride is a cell-permeable fluorescent probe used to stain DNA and chromosomes, with a preference for adenine and thymine rich DNA. Learn More
  15. Banoxantrone dihydrochloride

    Catalog No. A21432
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    Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. Learn More
  16. MW-150 dihydrochloride dihydrate

    Catalog No. A21860
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    p38α MAPK inhibitor
    MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. Learn More
  17. Liarozole dihydrochloride

    Catalog No. A21853
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    CYP450 dependent inhibitor
    Liarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase). Learn More
  18. Philanthotoxin 74 dihydrochloride

    Catalog No. A21739
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    AMPAR antagonist
    Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. Learn More
  19. SB-277011 dihydrochloride

    Catalog No. A21353
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    dopamine D3 receptor antagonist
    SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively. Learn More
  20. Azaphen dihydrochloride monohydrate

    Catalog No. A15009
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    serotonin reuptake inhibitor
    Azaphen is a potent inhibitor of the reuptake of serotonin. Learn More
  21. LY2801653 dihydrochloride

    Catalog No. A15150
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    MET inhibitor
    LY2801653 dihydrochloride is a potent, orally bioavailable, small-molecule inhibitor of c-MET kinase(Ki= 2 nM). Learn More
  22. H-1152 dihydrochloride

    Catalog No. A15102
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    ROCK inhibitor
    H-1152 dihydrochloride, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. Learn More
  23. CFI-400437 HCl

    Catalog No. A22463
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    CFI-400437 is a potent and selective inhibitor of polo-like kinase 4 (PLK4). Learn More
  24. Varenicline HCl

    Catalog No. A22519
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    Varenicline is a nicotinic receptor partial agonist. Learn More
  25. IT1t

    Catalog No. A20408
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    CXCR4 antagonist
    IT1t is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. Learn More
  26. Cefotiam hydrochloride

    Catalog No. A17481
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    anti-microbial
    Cefotetan Hydrochloride is a second-generation cephalosporin that is active against some strains of β-lactamase producing bacteria. It shows anti-microbial activity against Gram-positive and Gram-negative bacteria; it is more efficacious against Gram-negative and anaerobic bacteria Learn More
  27. Anlotinib HCl

    Catalog No. A17076
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    RTK inhibitor
    Anlotinib, also known as AL3818, is a receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic and anti-angiogenic activities. CAS: 1058156-90-3 (free base) 1360460-82-7 (HCl) Learn More
  28. GTS-21 (DMBX-A)

    Catalog No. A15950
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    nAChR agonist
    GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation. Learn More
  29. K-7174 2HCl

    Catalog No. A15446
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    Cell adhesion inhibitor
    K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1beta or TNF-alpha. Learn More
  30. NNC 55-0396

    Catalog No. A15188
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    Calcium channel blocker
    NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells. Learn More
  31. Mitoxantrone Hydrochloride

    Catalog No. A10596
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    Mitoxantrone Dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Learn More
  32. Meclizine 2HCl

    Catalog No. A11700
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    Meclizine is a human pregnane X receptor (hPXR) agonist. It possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Its antiemetic and antivertigo effects are not fully understood, but its central anticholinergic properties are partially responsible. Learn More
  33. BRL-15572 dihydrochloride

    Catalog No. A11178
    5-HT1D receptor antagonist

    BRL-15572 is a selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.

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  34. LMPTP INHIBITOR 1 dihydrochloride

    Catalog No. A22227
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    LMPTP inhibitor
    LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. Learn More
  35. LYN-1604 dihydrochloride

    Catalog No. A22230
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    ULK1 activator
    LYN-1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC). Learn More
  36. Iso-H7 dihydrochloride

    Catalog No. A22368
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    inhibitor of phosphokinase C
    Iso-H7 dihydrochloride is an inhibitor of phosphokinase C. Learn More
  37. IT1t dihydrochloride

    Catalog No. A22027
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    CXCR4 antagonist
    IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. Learn More
  38. SB-772077B dihydrochloride

    Catalog No. A20090
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    ROCK inhibitor
    SB-772077B dihydrochloride is an aminofurazan-based Rho kinase (ROCK) inhibitor with IC50s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively. Learn More
  39. ABT-702 dihydrochloride

    Catalog No. A19624
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    AK inhibitor
    ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor (IC50=1.7 nM). Learn More
  40. N-Desethyl amodiaquine dihydrochloride

    Catalog No. A21695
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    N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. Learn More
  41. d-Atabrine dihydrochloride

    Catalog No. A21654
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    d-Atabrine dihydrochloride is an active enantiomer of quinacrine which displays antiprion activity. Learn More
  42. Veliparib dihydrochloride

    Catalog No. A21356
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    PARP inhibitor
    Veliparib dihydrochloride is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively. Learn More
  43. Ro 10-5824 dihydrochloride

    Catalog No. A21986
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    dopamine D4 receptor partial agonist
    Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM. Learn More
  44. GSK-LSD1 dihydrochloride

    Catalog No. A21815
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    LSD1 inhibitor
    GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM. Learn More
  45. K-604 dihydrochloride

    Catalog No. A21773
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    ACAT-1 inhibitor
    K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45??0.06 μM. Learn More
  46. N8-Acetylspermidine dihydrochloride

    Catalog No. A21720
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    N8-Acetylspermidine dihydrochloride is a polyamine. Learn More
  47. TLR7/8 agonist 1 dihydrochloride

    Catalog No. A21700
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    TLR7/8 agonist
    TLR7/8 agonist 1 dihydrochloride is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline. Learn More
  48. MRT68921 dihydrochloride

    Catalog No. A21650
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    ULK1/ULK2 inhibitor
    MRT68921 dihydrochloride is the most potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively. Learn More
  49. l-Atabrine dihydrochloride

    Catalog No. A21646
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    l-Atabrine dihydrochloride is a less active enantiomer of quinacrine which displays antiprion activity. Learn More
  50. JNJ-37822681 dihydrochloride

    Catalog No. A21470
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    dopamine D2 receptor antagonist
    JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder. Learn More

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