Search results for 'gdc 0084'

44 Item(s)

per page

Set Ascending Direction
  1. GDC-0077

    Catalog No. A19494
    Quick View
    PI3Kα inhibitor
    GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0.038 nM). Learn More
  2. GDC-0927 Racemate

    Catalog No. A21507
    Quick View
    estrogen receptor degrader
    GDC-0927 Racemate (SRN-927 Racemate) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. Learn More
  3. GDC-0339

    Catalog No. A20920
    Quick View
    Pim kinase inhibitor
    GDC-0339 is a potent, orally bioavailable and well tolerated pan-Pim kinase inhibitor, with Kis of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively. GDC-0339 is discovered as a potential treatment of multiple myeloma. Learn More
  4. GDC-0349

    Catalog No. A11443
    Quick View
    mTOR inhibitor
    GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Learn More
  5. GDC-0326

    Catalog No. A20437
    Quick View
    PI3Kα inhibitor
    GDC-0326 is a potent and selective PI3Kα inhibitor with a Ki of 0.2 nM. Learn More
  6. GDC-0927

    Catalog No. A19747
    Quick View
    estrogen receptor antagonist
    GDC-0927 (SRN-927) is a novel, potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist. Learn More
  7. GDC-0575 dihydrochloride

    Catalog No. A21567
    Quick View
    CHK1 inhibitor
    GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity. Learn More
  8. GDC-0575 (ARRY-575, RG7741)

    Catalog No. A16811
    Quick View
    Chk1 inhibitor
    GDC-0575 (ARRY-575, RG7741) is a potent and selective CHK1 inhibitor with an IC50 of 1.2?nM. Learn More
  9. GDC-0152

    Catalog No. A14135
    Quick View
    IAP antagonist
    GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Learn More
  10. GDC-0032 (Taselisib)

    Catalog No. A12831
    Quick View
    PI3K inhibitor
    GDC-0032 is a potent, next-generation PI3 inhibitor targeting PI3 alpha. Learn More
  11. GDC-0834 Racemate

    Catalog No. A12706
    Quick View
    BTK inhibitor
    GDC-0834 Racemate is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK), investigated as a potential treatment for rheumatoid arthritis. Learn More
  12. GDC-0879

    Catalog No. A10420
    Quick View
    B-Raf inhibitor
    GDC-0879 is a specific inhibitor of B-Raf kinase enzyme,targeting B-Raf (V600E) (IC50: 0.13 nM). Learn More
  13. GDC-0980 (Apitolisib, RG7422)

    Catalog No. A11023
    Quick View
    mTOR/PI3K Inhibitor
    GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively. Learn More
  14. GDC-0941 (Pictilisib)

    Catalog No. A10421
    Quick View
    PI3K inhibitor
    GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) , with IC50 values (nM) of 3, 33, 3, 75, 1230 and 580 for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively. Learn More
  15. GDC-0834

    Catalog No. A21243
    Quick View
    BTK inhibitor
    GDC-0834 is a potent and selective BTK inhibitor. Learn More
  16. GDC-0623

    Catalog No. A12974
    Quick View
    MEK1 inhibitor
    GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1. Learn More
  17. GDC-0068 (Ipatasertib, RG-7440)

    Catalog No. A11246
    Quick View
    Akt Inhibitor
    GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays Learn More
  18. GDC-0449 (Vismodegib)

    Catalog No. A10258
    Quick View
    Hedgehog antagonist
    GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. Learn More
  19. GDC-0810 (Brilanestrant)

    Catalog No. A15958
    Quick View
    Estrogen receptor degrader
    Brilanestrant (GDC-0810, ARN-810) is a potent ER-α binder (ER-α, IC50 = 6.1 nM; ER-β, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-α degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors. Learn More
  20. GDC-0973 (Cobimetinib)

    Catalog No. A11441
    Quick View
    MEK1 inhibitor
    Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Learn More
  21. C188-9

    Catalog No. A16804
    Quick View
    STAT3 inhibitor
    C188-9 is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors. Learn More
  22. GF 109203X

    Catalog No. A13197
    Quick View
    PKC inhibitor
    GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM). Learn More
  23. CHK1 inhibitor

    Catalog No. A19623
    Quick View
    CHK1 inhibitor
    CHK1 inhibitor (GDC-0575 analog) is an inhibitor of CHK1. Learn More
  24. Pictilisib dimethanesulfonate

    Catalog No. A11444
    Quick View
    PI3Kα/δ inhibitor
    Pictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Learn More
  25. GDC0994 (Ravoxertinib)

    Catalog No. A13420
    Quick View
    ERK1/2 inhibitor
    GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. Learn More
  26. Ipatasertib dihydrochloride

    Catalog No. A21734
    Quick View
    pan-Akt inhibitor
    Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA. Learn More
  27. CUDC-427

    Catalog No. A20943
    Quick View
    pan-selective IAP antagonist
    CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers. Learn More
  28. Cobimetinib hemifumarate

    Catalog No. A18033
    Quick View
    MEK1 inhibitor
    Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM. Learn More
  29. Belvarafenib

    Catalog No. A13177
    Quick View
    pan RAF inhibitor
    Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. Learn More
  30. GDC0853

    Catalog No. A16339
    Quick View
    BTK inhibitor
    GDC0853 is a potent and orally BTK inhibitor. Learn More
  31. Cobimetinib (racemate)

    Catalog No. A15050
    MEK inhibitor
    Cobimetinib is a potent, highly selective inhibitor of MEK1/2. Learn More
  32. SB-224289 hydrochloride

    Catalog No. A21920
    Quick View
    5-HT1B receptor antagonist
    SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect. Learn More
  33. PF-06700841 P-Tosylate

    Catalog No. A21652
    Quick View
    dual JAK1/TYK2 inhibitor
    PF-06700841 P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. Learn More
  34. MK-0429

    Catalog No. A21173
    Quick View
    αvβ3 integrin antagonist
    MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide αvβ3 integrin antagonist with an IC50 of 80 nM. Learn More
  35. UAMC-3203

    Catalog No. A20084
    Quick View
    Ferroptosis inhibitor
    UAMC-3203 is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM. Learn More
  36. PF-06700841 tosylate

    Catalog No. A17176
    Quick View
    JAK1 and TYK2 inhibitor
    PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. CAS: 1883299-62-4 (free base) Learn More
  37. ECHS1 Human

    Catalog No. AP4088
    Quick View
    Enoyl CoA Hydratase, Short chain, 1, Mitochondrial Human Recombinant Learn More
  38. ECHS1 Human, Active

    Catalog No. AP4084
    Quick View
    Enoyl CoA Hydratase, Short chain, 1, Mitochondrial, Human Recombinant, Active Learn More
  39. HSP90 Alpha Human

    Catalog No. AP0084
    Quick View
    Heat Shock Protein-90 Alpha Human Recombinant Learn More
  40. NVP-ACC789

    Catalog No. A13240
    Quick View
    VEGFR-2 inhibitor
    NVP-ACC789 is an inhibitor of VEGFR-2 (FLK-1/KDR). Learn More
  41. Arbutin (Uva, p-Arbutin)

    Catalog No. A10084
    Quick View
    Tyrosinase inhibitor

    Arbutin is a glycosylated hydroquinone used in traditional Chinese medicine (TCM). Arbutin inhibits melanin formation due to its tyrosinase inhibitory activity.

    Learn More
  42. G-479

    Catalog No. A14380
    Quick View
    MEK inhibitor
    G-479 is an potent MEK inhibitor. G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects. Learn More
  43. Cobimetinib (R-enantiomer)

    Catalog No. A15051
    Quick View
    MEK inhibitor
    Cobimetinib R-enantiomer is the R-enantiomer of Cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2). Learn More
  44. ABT-199 (Venetoclax)

    Catalog No. A12500
    Quick View
    Bcl-2 inhibitor
    ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2. Learn More

44 Item(s)

per page

Set Ascending Direction