Search results for 'gdc 0084'

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  1. GDC-0077

    Catalog No. A19494
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    PI3Kα inhibitor
    GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0.038 nM). Learn More
  2. GDC-0927 Racemate

    Catalog No. A21507
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    estrogen receptor degrader
    GDC-0927 Racemate (SRN-927 Racemate) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. Learn More
  3. GDC-0339

    Catalog No. A20920
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    Pim kinase inhibitor
    GDC-0339 is a potent, orally bioavailable and well tolerated pan-Pim kinase inhibitor, with Kis of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively. GDC-0339 is discovered as a potential treatment of multiple myeloma. Learn More
  4. GDC-0349

    Catalog No. A11443
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    mTOR inhibitor
    GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Learn More
  5. GDC-0326

    Catalog No. A20437
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    PI3Kα inhibitor
    GDC-0326 is a potent and selective PI3Kα inhibitor with a Ki of 0.2 nM. Learn More
  6. GDC-0927

    Catalog No. A19747
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    estrogen receptor antagonist
    GDC-0927 (SRN-927) is a novel, potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist. Learn More
  7. GDC-0575 dihydrochloride

    Catalog No. A21567
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    CHK1 inhibitor
    GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity. Learn More
  8. GDC-0575 (ARRY-575, RG7741)

    Catalog No. A16811
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    Chk1 inhibitor
    GDC-0575 (ARRY-575, RG7741) is a potent and selective CHK1 inhibitor with an IC50 of 1.2?nM. Learn More
  9. GDC-0152

    Catalog No. A14135
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    IAP antagonist
    GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Learn More
  10. GDC-0032 (Taselisib)

    Catalog No. A12831
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    PI3K inhibitor
    GDC-0032 is a potent, next-generation PI3 inhibitor targeting PI3 alpha. Learn More
  11. GDC-0834 Racemate

    Catalog No. A12706
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    BTK inhibitor
    GDC-0834 Racemate is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK), investigated as a potential treatment for rheumatoid arthritis. Learn More
  12. GDC-0879

    Catalog No. A10420
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    B-Raf inhibitor
    GDC-0879 is a specific inhibitor of B-Raf kinase enzyme,targeting B-Raf (V600E) (IC50: 0.13 nM). Learn More
  13. GDC-0980 (Apitolisib, RG7422)

    Catalog No. A11023
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    mTOR/PI3K Inhibitor
    GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively. Learn More
  14. GDC-0941 (Pictilisib)

    Catalog No. A10421
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    PI3K inhibitor
    GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) , with IC50 values (nM) of 3, 33, 3, 75, 1230 and 580 for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively. Learn More
  15. GDC-0834

    Catalog No. A21243
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    BTK inhibitor
    GDC-0834 is a potent and selective BTK inhibitor. Learn More
  16. GDC-0623

    Catalog No. A12974
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    MEK1 inhibitor
    GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1. Learn More
  17. GDC-0068 (Ipatasertib, RG-7440)

    Catalog No. A11246
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    Akt Inhibitor
    GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays Learn More
  18. GDC-0449 (Vismodegib)

    Catalog No. A10258
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    Hedgehog antagonist
    GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. Learn More
  19. GDC-0810 (Brilanestrant)

    Catalog No. A15958
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    Estrogen receptor degrader
    Brilanestrant (GDC-0810, ARN-810) is a potent ER-α binder (ER-α, IC50 = 6.1 nM; ER-β, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-α degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors. Learn More
  20. GDC-0973 (Cobimetinib)

    Catalog No. A11441
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    MEK1 inhibitor
    Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Learn More
  21. C188-9

    Catalog No. A16804
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    STAT3 inhibitor
    C188-9 is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors. Learn More
  22. GF 109203X

    Catalog No. A13197
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    PKC inhibitor
    GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM). Learn More
  23. CHK1 inhibitor

    Catalog No. A19623
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    CHK1 inhibitor
    CHK1 inhibitor (GDC-0575 analog) is an inhibitor of CHK1. Learn More
  24. Pictilisib dimethanesulfonate

    Catalog No. A11444
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    PI3Kα/δ inhibitor
    Pictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Learn More
  25. GDC0994 (Ravoxertinib)

    Catalog No. A13420
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    ERK1/2 inhibitor
    GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. Learn More
  26. Ipatasertib dihydrochloride

    Catalog No. A21734
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    pan-Akt inhibitor
    Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA. Learn More
  27. CUDC-427

    Catalog No. A20943
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    pan-selective IAP antagonist
    CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers. Learn More
  28. Cobimetinib hemifumarate

    Catalog No. A18033
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    MEK1 inhibitor
    Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM. Learn More
  29. Belvarafenib

    Catalog No. A13177
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    pan RAF inhibitor
    Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. Learn More
  30. GDC0853

    Catalog No. A16339
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    BTK inhibitor
    GDC0853 is a potent and orally BTK inhibitor. Learn More
  31. Cobimetinib (racemate)

    Catalog No. A15050
    MEK inhibitor
    Cobimetinib is a potent, highly selective inhibitor of MEK1/2. Learn More
  32. SB-224289 hydrochloride

    Catalog No. A21920
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    5-HT1B receptor antagonist
    SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect. Learn More
  33. PF-06700841 P-Tosylate

    Catalog No. A21652
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    dual JAK1/TYK2 inhibitor
    PF-06700841 P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. Learn More
  34. MK-0429

    Catalog No. A21173
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    αvβ3 integrin antagonist
    MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide αvβ3 integrin antagonist with an IC50 of 80 nM. Learn More
  35. UAMC-3203

    Catalog No. A20084
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    Ferroptosis inhibitor
    UAMC-3203 is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM. Learn More
  36. PF-06700841 tosylate

    Catalog No. A17176
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    JAK1 and TYK2 inhibitor
    PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. CAS: 1883299-62-4 (free base) Learn More
  37. ECHS1 Human

    Catalog No. AP4088
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    Enoyl CoA Hydratase, Short chain, 1, Mitochondrial Human Recombinant Learn More
  38. ECHS1 Human, Active

    Catalog No. AP4084
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    Enoyl CoA Hydratase, Short chain, 1, Mitochondrial, Human Recombinant, Active Learn More
  39. HSP90 Alpha Human

    Catalog No. AP0084
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    Heat Shock Protein-90 Alpha Human Recombinant Learn More
  40. NVP-ACC789

    Catalog No. A13240
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    VEGFR-2 inhibitor
    NVP-ACC789 is an inhibitor of VEGFR-2 (FLK-1/KDR). Learn More
  41. Arbutin (Uva, p-Arbutin)

    Catalog No. A10084
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    Tyrosinase inhibitor

    Arbutin is a glycosylated hydroquinone used in traditional Chinese medicine (TCM). Arbutin inhibits melanin formation due to its tyrosinase inhibitory activity.

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  42. G-479

    Catalog No. A14380
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    MEK inhibitor
    G-479 is an potent MEK inhibitor. G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects. Learn More
  43. Cobimetinib (R-enantiomer)

    Catalog No. A15051
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    MEK inhibitor
    Cobimetinib R-enantiomer is the R-enantiomer of Cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2). Learn More
  44. ABT-199 (Venetoclax)

    Catalog No. A12500
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    Bcl-2 inhibitor
    ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2. Learn More

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