Search results for 'jwh 073'

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  1. Thrombin Human, HEK

    Catalog No. AP2537
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    Thrombin Human Recombinant, HEK Learn More
  2. CAPN1

    Catalog No. AP1824
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    Human Calpain-1 Catalytic Subunit Learn More
  3. CTSD Human

    Catalog No. AP3800
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    Cathepsin-D Human Recombinant Learn More
  4. MI-1061

    Catalog No. A18450
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    MDM2 inhibitor
    MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity. Learn More
  5. HCV Core Genotype-5

    Catalog No. AP6073
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    Hepatitis C Virus Core Genotype-5 Recombinant Learn More
  6. E3 ligase Ligand 10

    Catalog No. A19045
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    E3 ubiquitin ligase ligand
    E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. Learn More
  7. HG6-64-1

    Catalog No. A16022
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    B-Raf inhibitor
    HG6-64-1 is a potent and selective B-Raf and mutant B-Raf inhibitor; more information can be found in Patent WO 2011090738. Learn More
  8. Saikosaponin C

    Catalog No. A14571
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    Saikosaponin C induces endothelial cells growth, migration and capillary tube formation. Learn More
  9. GSK547

    Catalog No. A19073
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    RIP1 inhibitor
    GSK547 (GSK-547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer. Learn More
  10. Bay 65-1942

    Catalog No. A11339
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    IKKβ inhibitor
    Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity. Learn More
  11. Enterokinase Human

    Catalog No. AP4003
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    Enteropeptidase/ Enterokinase, Light Chain Human Recombinant Learn More
  12. Haptoglobin Human

    Catalog No. AP1980
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    Haptoglobin Human Learn More
  13. mTOR inhibitor (mTOR-IN-1)

    Catalog No. A15175
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    mTOR inhibitor
    mTOR inhibitor is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 1.5 nM. Learn More
  14. Bay 65-1942 HCl

    Catalog No. A11338
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    IKKβ kinase inhibitor
    Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity. Learn More
  15. E-3810

    Catalog No. A15073
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    VEGFR/FGFR Inhibitor
    E-3810 is a potent and selective dual inhibitor of VEGF and FGF receptors with IC50 values of 7 nM, 25 nM, 10 nM, 17.5 nM and 82.5 nM for VEGFR-1, VEGFR-2, VEGFR-3, FGFR-1 and FGFR-2, respectively. Learn More
  16. Demethoxydeacetoxypseudolaric acid B analog

    Catalog No. A18986
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    Demethoxydeacetoxypseudolaric acid B analog (Compound 13b) is semi-synthesized by efficient routines from Pseudolaric acid B. It has potent activities against HMEC-1, HL-60, A-549, MB-MDA-468, BEL-7402, HCT116, and Hela cells with IC50s ranging from 0.136 to 1.162 μM. Learn More
  17. Pamiparib

    Catalog No. A17073
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    PARP inhibitor
    Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. CAS: 1446261-44-1 (free base) 2086689-94-1 (maleate) 2086689-93-0 (hydrate) Learn More
  18. Demethylzeylasteral

    Catalog No. A14745
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    Demethylzeylasteral exhibits dose-dependent inhibitory behaviour towards estradiol glucuronidation. Learn More
  19. HPSE Active

    Catalog No. AP4073
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    Recombinant Human Heparanase-1 Active Learn More
  20. GSK256066

    Catalog No. A11073
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    PDE Inhibitor
    GSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equal affinity and has a high HARBS (High-Affinity Rolipram Binding Site) ratio (>17). Learn More
  21. SBC-110736

    Catalog No. A20151
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    PCSK9 inhibitor
    SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor extracted from patent WO2014150395A1, Figure 1. Learn More
  22. Pimobendan (Vetmedin)

    Catalog No. A10733
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    PDE inhibitor
    Pimobendan (Vetmedin) is a calcium sensitizer with positive inotropic and vasodilator effects. It is also a selective inhibitor of phosphodiesterase III (PDE3). Learn More
  23. (+)-ITD 1

    Catalog No. A16073
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    TGF-β inhibitor
    (+)-ITD-1 is a resolved enantiomer of ITD-1 that possesses a greater than 2-fold increase in TGF-β inhibition (~400 nM) and 1.3-fold increase in cardiogenesis compared to the racemic ITD-1. Learn More
  24. FSBP Human

    Catalog No. AP0704
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    Fibrinogen Silencer Binding Protein Human Recombinant Learn More
  25. VEGF (121 a.a.) Mouse

    Catalog No. AP3722
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    Vascular Endothelial Growth Factor (121 a.a.) Mouse Recombinant Learn More
  26. PHF5A Human

    Catalog No. AP0734
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    PHD Finger Protein 5A Human Recombinant Learn More
  27. PPP1R11 Human

    Catalog No. AP0739
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    Protein Phosphatase 1, Regulatory Subunit 11 Human Recombinant Learn More
  28. MIG Human, His

    Catalog No. AP5716
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    MIG Human Recombinant (CXCL9), His Tag Learn More
  29. ASGR2 Human

    Catalog No. AP0466
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    Asialoglycoprotein Receptor 2 Human Recombinant Learn More
  30. ANXA7 Human

    Catalog No. AP1894
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    Annexin A7 Human Recombinant Learn More
  31. CRYGD Human

    Catalog No. AP2321
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    Crystallin, Gamma D Human Recombinant Learn More
  32. VEGF Mouse, Sf9

    Catalog No. AP3709
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    Vascular Endothelial Growth Factor Mouse Recombinant, Sf9 Learn More
  33. S100A12 Human

    Catalog No. AP0732
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    S100 Calcium Binding Protein A12 Human Recombinant Learn More
  34. ADH1A Human, sf9

    Catalog No. AP3900
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    Alcohol Dehydrogenase 1A, Human Recombinant, sf9 Learn More
  35. MBP E.coli

    Catalog No. AP0737
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    Myelin Basic Protein E.coli Recombinant Learn More
  36. PRSS7 Human

    Catalog No. AP4524
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    Protease Serine 7 Human Recombinant Learn More
  37. Haptoglobin (19-347) Human

    Catalog No. AP1133
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    Haptoglobin (19-347 a.a) Human Recombinant Learn More
  38. H9N2 Hong-Kong

    Catalog No. AP6213
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    H9N2 Influenza-A Virus Hong-Kong/1073/99 Recombinant Learn More
  39. EIF4E Mouse

    Catalog No. AP1647
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    Eukaryotic Translation Initiation Factor 4E Recombinant Mouse Learn More
  40. FTH1 Human

    Catalog No. AP2073
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    Ferritin Human Recombinant, Heavy Chain Learn More
  41. Thrombin Human Recombinant

    Catalog No. AP2538
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    Thrombin Human Recombinant Learn More
  42. NMB Human

    Catalog No. AP0730
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    Neuromedin B Human Recombinant Learn More
  43. VEGF Mouse, His

    Catalog No. AP3726
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    Vascular Endothelial Growth Factor Mouse Recombinant, His Tag Learn More
  44. FBXO6 Human

    Catalog No. AP0735
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    F-Box Protein 6 Human Recombinant Learn More
  45. ATP5F1 Human

    Catalog No. AP1073
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    Synthase Transporting Mitochondrial Fo Complex B1 Human Recombinant Learn More
  46. MIG Human

    Catalog No. AP5717
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    MIG Human Recombinant (CXCL9) Learn More
  47. ANXA2 Human

    Catalog No. AP0791
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    Annexin A2 Human Learn More
  48. C8G Human

    Catalog No. AP2353
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    Complement Component 8, Gamma Human Recombinant Learn More
  49. GROEL (27-573) Human

    Catalog No. AP0073
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    GroEL (HSP60) (27-573 a.a.) Human Recombinant Learn More
  50. VEGF Mouse

    Catalog No. AP3715
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    Vascular Endothelial Growth Factor Mouse Recombinant Learn More
  51. TEN1 Human

    Catalog No. AP0733
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    TEN1 Human Recombinant Learn More
  52. ADH1A Human

    Catalog No. AP3944
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    Alcohol Dehydrogenase 1A Human Recombinant Learn More
  53. STOM Human

    Catalog No. AP0738
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    Stomatin Human Recombinant Learn More
  54. gAcrp30 Human

    Catalog No. AP5073
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    Globular Adiponectin Human Recombinant Learn More
  55. CRYGC Human

    Catalog No. AP0291
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    Crystallin, Gamma C Human Recombinant Learn More
  56. ANXA2 Human

    Catalog No. AP2189
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    Annexin A2 Human Recombinant Learn More
  57. FABP4 Antibody

    Catalog No. AP3073
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    Fatty Acid Binding Protein 4, Mouse Anti Human Learn More
  58. ASPSCR1 Human

    Catalog No. AP0731
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    Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 Human Recombinant Learn More
  59. TEF Human

    Catalog No. AP0736
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    Thyrotrophic Embryonic Factor Human Recombinant Learn More
  60. ACYP1 Human

    Catalog No. AP4432
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    Acylphosphatase 1 Human Recombinant Learn More
  61. HPR Human

    Catalog No. AP1121
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    Haptoglobin-Related Protein Human Recombinant Learn More
  62. EIF1B Human

    Catalog No. AP0978
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    Eukaryotic Translation Initiation Factor 1B Human Recombinant Learn More
  63. Haptoglobin Human

    Catalog No. AP1988
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    Haptoglobin Human Recombinant Learn More
  64. Garcinone D

    Catalog No. A14800
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    Garcinone D, extracted from Garcinia mangostana. Learn More
  65. BN82002

    Catalog No. A19386
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    CDC25 phosphatase family inhibitor
    BN82002 is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. Learn More
  66. GDC-0349

    Catalog No. A11443
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    mTOR inhibitor
    GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Learn More
  67. Pocapavir (SCH-48973)

    Catalog No. A18331
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    EV capsid inhibitor
    Pocapavir is an investigational enterovirus (EV) capsid inhibitor. Learn More
  68. Isochlorogenic acid B

    Catalog No. A12073
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    Isochlorogenic acid B is derived from the flowerbud of Lonicera japonica Thunb. Learn More
  69. Safinamide Mesylate (FCE28073)

    Catalog No. A10818
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    MAO Inhibitor
    Safinamide Mesylate is mesylate salt of Safinamide, which selectively and reversibly inhibits MAO-B with IC50 of 0.45 μM. Learn More
  70. PB-22

    Catalog No. A14110
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    PB-22 is an analog of JWH 018 which differs by having 8-hydroxyquinoline replacing the naphthalene group of JWH 018. Learn More
  71. LDC000067

    Catalog No. A14273
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    CDK inhibitor
    LDC000067 is a highly selective CDK9 inhibitor . Learn More
  72. Rauwolscine

    Catalog No. A13426
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    α2-adrenergic receptor antagonist
    Rauwolscine is a natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM). Learn More
  73. ZT-12-037-01

    Catalog No. A18395
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    ATP-competitive STK19 inhibitor
    ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor. ZT-12-037-01 effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo. Learn More
  74. Sivelestat sodium salt

    Catalog No. A14073
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    Neutrophil elastase inhibitor
    Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. It inhibits NF-kB activation and LTB4-induced neutrophil transmigration in vitro. Learn More
  75. PIK-93

    Catalog No. A10731
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    PI3K inhibitor
    PIK 93 selectively inhibits the type III PI 4-kinase enzyme, and small interfering RNA-mediated down-regulation of the individual PI 4-kinase enzymes. Learn More
  76. BC-1215

    Catalog No. A18605
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    FBXO3 inhibitor
    BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination. Learn More
  77. LY223982

    Catalog No. A19436
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    LTB4 receptor inhibitor
    LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. Learn More
  78. Pirarubicin

    Catalog No. A10735
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    Topoisomerase II inhibitor
    Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin. Intercalates into DNA and interacts with Topo II (topoisomerase II) and supressing DNA replication Learn More
  79. Nitisinone

    Catalog No. A11093
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    HPPD inhibitor
    Nitrisinone is a competitive inhibitor that reversibly inhibits 4-Hydroxyphenylpyruvate oxidase (dioxygenase). Learn More
  80. CY-09

    Catalog No. A16924
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    NLRP3 inhibitor
    CY-09 is a NLRP3 inhibitor with Kd value of 500 nM. It directly binds to ATP-binding motif of NLRP3 NACHT domain. Learn More
  81. Clemizole

    Catalog No. A13073
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    H1 histamine receptor antagonist.
    Clemizole is an H1 histamine receptor antagonist. Learn More
  82. Pizotifen malate

    Catalog No. A10738
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    Pizotifen malate, a derivative of benzocycloheptathiophene, is a tricyclic compound found to be a potent inhibitor of SR-2 receptor activity. Learn More
  83. Piperine (1-Piperoylpiperidine)

    Catalog No. A10734
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    Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide. Learn More
  84. Piroxicam (Feldene)

    Catalog No. A10736
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    COX inhibitor
    Piroxicam is an effective and potent inhibitor of prostaglandin synthesis and a Cox-1 and Cox-2 inhibitor. Learn More
  85. Lincomycin Hydrochloride Monohydrate

    Catalog No. A17584
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    Antibacterial agent
    Lincomycin hydrochloride is a peptidyl transferase and protein translation inhibitor used to treat bacterial infections. It also inhibits growth of plasmodium. Learn More
  86. XL184 free base (Cabozantinib)

    Catalog No. A10996
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    VEGFR inhibitor
    XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2. Learn More
  87. PF-04554878 (Defactinib)

    Catalog No. A11929
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    FAK inhibitor
    PF-04554878 is a novel FAK kinase inhibitor that decreases growth and induces apoptosis in pancreatic neuroendocrine tumor cells Learn More
  88. CP-690550 (Tofacitinib citrate)

    Catalog No. A10241
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    JAK3 inhibitor
    CP-690550 (Tofacitinib citrate) is an orally available, highly selective inhibitor of the Janus kinase (JAK) family of enzymes. Learn More
  89. KJ Pyr 9

    Catalog No. A16324
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    MYC inhibitor
    KJ Pyr 9 is a novel small-molecule inhibitor of MYC, KJ-Pyr-9, from a Krhnke pyridine library. Learn More
  90. Pimecrolimus

    Catalog No. A10732
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    Pimecrolimus is a natural ascomycin macrolactam that binds to macrophilin-12 (FKBP-12) and inhibits calcineurin as well as prolyl isomerase (rotamase). Learn More
  91. PLX4032 (Vemurafenib)

    Catalog No. A10739
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    Raf inhibitor
    PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM. Learn More
  92. AMG-073 HCl (Cinacalcet HCl)

    Catalog No. A10219
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    CaSR activator
    AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium. Learn More
  93. PIK-90

    Catalog No. A10730
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    PI3K Inhibitor
    PIK-90 is a synthetic phosphoinositide 3-kinase (PI3K) inhibitor with IC50 values (nM) of 11, 350, 18, and 58 for p110 α, β, γ and δ isoforms, low mTOR activity. Learn More
  94. AMG 073 (Cinacalcet)

    Catalog No. A11314
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    CaSR activator
    AMG-073 (Cinacalcet) represents a new class of compounds for the treatment of hyperparathyroidism. Learn More
  95. Pitavastatin calcium (Livalo)

    Catalog No. A10737
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    HMG-CoA reductase inhibitor
    Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Learn More
  96. Amphotericin B

    Catalog No. A10073
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    Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. Amphotericin B induces K+ leakage, which is separate from its lethal action, as was demonstrated in human erythrocytes and is due to the inhibitory effect on the Na+/K+ pump. Learn More

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