Search results for 'lorcaserin hydrochloride apd 356'

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  1. Olorinab

    Catalog No. A19476
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    CB2 agonist
    Olorinab (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist, with an EC50 of 6.2 nM for hCB2. Learn More
  2. Nelotanserin

    Catalog No. A21506
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    5-HT2A inverse agonist
    Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively. Learn More
  3. Ralinepag

    Catalog No. A21073
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    IP receptor agonist
    Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively. Learn More
  4. Temanogrel

    Catalog No. A17094
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    5-HT(2A) receptor agonist
    Temanogrel, also known as APD791, is a highly selective 5-hydroxytryptamine2A receptor inverse agonist under development for the treatment of arterial thrombosis. Learn More
  5. APD597 (JNJ-38431055)

    Catalog No. A15452
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    GPR119 agonist
    APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119. Learn More
  6. APD668

    Catalog No. A14342
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    GPR119 agonist
    APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively. Learn More
  7. OABK hydrochloride

    Catalog No. A20546
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    OABK hydrochloride is a small-molecule switch that can be used to control protein activity. Learn More
  8. Pirmenol hydrochloride

    Catalog No. A18009
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    Pirmenol hydrochloride inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM. Learn More
  9. A 784168

    Catalog No. A22264
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    antagonist of Vanilloid receptor type 1
    A-784168 is a potent and selective antagonist of Vanilloid receptor type 1 (TRPV1). Learn More
  10. Motixafortide

    Catalog No. A22276
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    CXCR4 antagonist
    Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC50 vakue of ??1 nM. Learn More
  11. TC-I 2000

    Catalog No. A22628
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    TRPM8 channel blocker
    TC-I 2000 is a TRPM8 channel blocker that inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells Learn More
  12. MI-538

    Catalog No. A20753
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    menin and MLL fusion protein inhibitor
    MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. Learn More
  13. Setmelanotide

    Catalog No. A20689
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    MC4R agonist
    Setmelanotide (RM-493; BIM-22493; IRC-022493) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively. Learn More
  14. Vaborbactam

    Catalog No. A20638
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    β-lactamase inhibitor
    Vaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor. Learn More
  15. Saroglitazar

    Catalog No. A20636
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    PPAR agonist
    Saroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively. Learn More
  16. Calcitriol Impurities A

    Catalog No. A20633
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    Calcitriol Impurities A is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Learn More
  17. GS-444217

    Catalog No. A20517
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    ASK1 inhibitor
    GS-444217 is a potent, orally available and selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87 nM. Learn More
  18. KDM5-IN-1

    Catalog No. A20507
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    KDM5 inhibitor
    KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor with an IC50 of 15.1 nM. Learn More
  19. BAR502

    Catalog No. A20433
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    dual FXR and GPBAR1 agonist
    BAR502 is a dual FXR and GPBAR1 agonist with IC50 values of 2 μM and 0.4 μM, respectively. Learn More
  20. PTP1B-IN-2

    Catalog No. A20428
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    PTP1B inhibitor
    PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 50 nM. Learn More
  21. Acelarin

    Catalog No. A20397
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    Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine. Learn More
  22. Roflumilast Impurity E

    Catalog No. A20365
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    PDE-4 inhibitor
    Roflumilast Impurity E is the impurity of Roflumilast. Roflumilast(Daliresp) is a drug which acts as a selective and long-acting inhibitor of the enzyme PDE-4 with an IC50 value of 0.8 nM. Learn More
  23. 9-Propenyladenine

    Catalog No. A20357
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    9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors, which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV. Learn More
  24. ML402

    Catalog No. A19594
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    TREK-1 activator
    ML402 is a selective TREK-1 activator. Learn More
  25. β-Apo-13-carotenone

    Catalog No. A19360
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    antagonist of RXRα
    β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα. Learn More
  26. XL041

    Catalog No. A19270
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    LXRβ-selective agonist
    XL041 (BMS-852927) is an LXRβ-selective agonist. Learn More
  27. IMD-0560

    Catalog No. A19224
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    IκB kinase β inhibitor
    IMD-0560 is a novel IκB kinase β inhibitor. Learn More
  28. Eprinomectin

    Catalog No. A21657
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    Eprinomectin(MK-397) is an avermectin selected for development as a topical endectocide; has anthelmintic, insecticidal and miticidal activity. Learn More
  29. DM4

    Catalog No. A21440
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    DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate. Learn More
  30. Monepantel

    Catalog No. A21195
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    Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits. Learn More
  31. p38-α MAPK-IN-1

    Catalog No. A21036
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    MAPK14 inhibitor
    p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay. Learn More
  32. ISA-2011B

    Catalog No. A20960
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    PIP5Kα inhibitor
    ISA-2011B is a PIP5Kα inhibitor with promising anticancer effects . Learn More
  33. HSP70-IN-1

    Catalog No. A21716
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    HSP inhibitor
    HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM. Learn More
  34. (Z)-9-Propenyladenine

    Catalog No. A21687
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    (Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral drug known as nucleotide analogue reverse transcriptase (NtART) inhibitor, which blocks reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV. Learn More
  35. Bay 41-4109 less active enantiomer

    Catalog No. A21681
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    HBV inhibitor
    Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM. Learn More
  36. MKC9989

    Catalog No. A21602
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    Hydroxy aryl aldehydes (HAA) inhibitor
    MKC9989 is a Hydroxy aryl aldehydes (HAA) inhibitor and also inhibits IRE1α with an IC50 of 0.23 to 44 μM. Learn More
  37. PE859

    Catalog No. A21592
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    Tau and Aβ aggregation inhibitor
    PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively. Learn More
  38. LUF6000

    Catalog No. A21532
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    A3 adenosine receptor allosteric modulator
    LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR). Learn More
  39. Gepotidacin

    Catalog No. A21086
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    topoisomerase II inhibitor
    Gepotidacin (GSK2140944) is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor. Learn More
  40. RR6

    Catalog No. A21054
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    vanin inhibitor
    RR6 is a selective, reversible, and competitive vanin inhibitor. Learn More
  41. EL-102

    Catalog No. A20925
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    HIF1α inhibitor
    EL102 is a inhibitor of HIF1α , Which can inhibit tubulin polymerisation and decreased microtubule stability. Learn More
  42. ADX88178

    Catalog No. A20922
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    mGluR4 PAM
    ADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4. Learn More
  43. Acebilustat

    Catalog No. A20867
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    leukotriene A4 hydrolase inhibitor
    Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory drug. Learn More
  44. Fluocinonide(Vanos)

    Catalog No. A11688
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    Fluocinonide is a potent glucocorticoid steroid used topically as an anti-inflammatory agent for the treatment of skin disorders. Learn More
  45. LMPTP INHIBITOR 1 dihydrochloride

    Catalog No. A22227
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    LMPTP inhibitor
    LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. Learn More
  46. LYN-1604 dihydrochloride

    Catalog No. A22230
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    ULK1 activator
    LYN-1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC). Learn More
  47. Pertussis Toxin

    Catalog No. A19356
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    protein-based AB5-type exotoxin
    Pertussis Toxin is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. Learn More
  48. ML299

    Catalog No. A22094
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    PLD1/PLD2 dual inhibitor
    ML299 (VU0463568) is a dual inhibitor of PLD1 and PLD2 with IC50 of 6 nM and 20 nM, respectively. Learn More
  49. ASLAN003

    Catalog No. A22140
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    Dihydroorotate Dehydrogenase (DHODH) inhibitor
    ASLAN003 is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. Learn More
  50. AUNP-12

    Catalog No. A22274
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    peptide antagonist
    AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. Learn More

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