Search results for 'ltx 315'

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  1. GSK106 hydrochloride

    Catalog No. A22116
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    negative control compound
    GSK106 is a negative control compound that can be used in binding and functional assays for PAD4 inhibitors. Learn More
  2. FLTX1

    Catalog No. A22120
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    antiestrogenic properties
    FLTX1 is a fluorescent Tamoxifen derivative that can specifically label intracellular Tamoxifen-binding sites (estrogen receptors) under permeabilized and non-permeabilized conditions. FLTX1 exhibits the potent antiestrogenic properties of Tamoxifen in breast cancer cells. FLTX1 is devoid of the estrogenic agonistic effect on the uterus. Learn More
  3. Higenamine

    Catalog No. A22315
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    β2-AR agonist
    Higenamine (Norcoclaurine), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Learn More
  4. ML095 HCl

    Catalog No. A22545
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    PLAP inhibitor
    ML-095 is an inhibitor of PLAP (IC50 = 3.7 μM) that demonstrates high selectivity against the related alkaline phosphatases, TNAP and IAP (IC50s > 100 μM). Learn More
  5. JTE-013

    Catalog No. A22583
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    S1P2 antagonist
    JTE-013 is a potent and specific S1P2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P2 with IC50s of 17 nM and 22 nM, respectively. Learn More
  6. Nor-benzetimide

    Catalog No. A22684
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    mAChR antagonist
    Nor-benzetimide is a major metabolite of Benzetimide. Benzetimide is a mAChR antagonist with anticholinergic activity. Learn More
  7. ILK-IN-2

    Catalog No. A22685
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    ILK inhibitor
    ILK-IN-2 (OSU-T315 analog) is a ILK inhibitor. Learn More
  8. Pyr10

    Catalog No. A20786
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    TRPC3 inhibitor
    Pyr10is a novel TRPC3-selective inhibitor, IC50 of Ca2+ influx inhibition by Pyr10 in carbachol-stimulated YFP-TRPC3-transfected HEK293 cells for ROCE and thapsigargin-depleted native RBL-2H3 cells for SOCE is 0.72 uM and 13.08 uM. Learn More
  9. PrPSc-IN-1

    Catalog No. A20488
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    PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrPSc, inhibits its accumulation, with an IC50 of 1.6 μM. Anti-prion activity. Learn More
  10. BMS-986020

    Catalog No. A20393
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    LPA1 antagonist
    BMS-986020 is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist. Learn More
  11. Diacylglycerol acyltransferase inhibitor-1

    Catalog No. A20315
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    DGAT1 inhibitor
    Diacylglycerol acyltransferase inhibitor-1 is a diacylglycerol acyltransferase (DGAT1) inhibitor. Learn More
  12. Fosmidomycin sodium salt

    Catalog No. A20292
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    Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial drug, which is active against both Gram-negative and Gram-positive bacteria. Learn More
  13. ALB-127158(a)

    Catalog No. A20211
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    MCH1 receptor antagonist
    ALB-127158(a) is a potent and selective melanin concentrating hormone 1 (MCH1) receptor antagonist. Learn More
  14. VU591 hydrochloride

    Catalog No. A20009
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    ROMK inhibitor
    VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM. Learn More
  15. PI3Kγ inhibitor 2

    Catalog No. A19606
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    PI3Kγ inhibitor
    PI3Kγ inhibitor 2 (Compound 16) is an orally bioavailable, CNS-penetrant, isoform selective PI3Kγ inhibitor with a Ki of 4 nM. Learn More
  16. BRD 4354

    Catalog No. A19532
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    HDAC5/HDAC9 inhibitor
    BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively. Learn More
  17. Praliciguat

    Catalog No. A19315
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    guanylate cyclase stimulator
    Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC50 of 197 nM. Learn More
  18. BCR-ABL-IN-2

    Catalog No. A21043
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    BCR-ABL inhibitor
    BCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1native and ABL1T315I, respectively. Learn More
  19. Defactinib

    Catalog No. A21958
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    FAK inhibitor
    Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities. Learn More
  20. DO34 analog

    Catalog No. A21821
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    triazole DAGL(α) inhibitor
    DO34 analog is a triazole DAGL(α) inhibitor extracted from patent WO2017096315 A1, compound 100. Learn More
  21. Gamma-glutamylcysteine (TFA)

    Catalog No. A21746
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    Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Learn More
  22. Nampt-IN-1

    Catalog No. A21399
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    NAMPT inhibitor
    Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM. Learn More
  23. Vercirnon

    Catalog No. A21315
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    CCR9 antagonist
    Vercirnon (GSK-1605786) is an orally bioavailable, selective, and potent antagonist of CCR9, with an IC50 of 10 nM, used in the research of inflammatory bowel diseases. Learn More
  24. CB30865

    Catalog No. A21209
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    Nampt inhibitor
    CB30865(ZM 242421) is a potent inhibitor of Nampt , an enzyme present in the NAD biosynthetic pathway. Learn More
  25. Valifenalate

    Catalog No. A21111
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    Valifenalate(IR5885; Valiphenal), which is approved for application on high-value crops such as grapes, tomatoes and other vegetables, is effective against various types of mildew and is currently marketed primarily under the Valis moniker; insecticide agent. Learn More
  26. OSU-T315

    Catalog No. A20870
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    ILK inhibitor
    OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). Learn More
  27. Benzo[a]pyrene

    Catalog No. A13158
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    Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies. Learn More
  28. Docosahexaenoic Acid methyl ester

    Catalog No. A12315
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    Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed. Learn More
  29. Gboxin

    Catalog No. A13034
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    oxidative phosphorylation inhibitor
    Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase. Antitumour activity. Learn More
  30. ZD-1611

    Catalog No. A13151
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    ETA receptor antagonist
    ZD-1611 is a potent, orally active, selective ETA receptor antagonist, used for the research of ischemic stroke. Learn More
  31. KRas G12C inhibitor 1

    Catalog No. A13152
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    Kras-G12C inhibitor 1
    KRas G12C inhibitor 1 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1. Learn More
  32. WNK-IN-11

    Catalog No. A13153
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    WNK inhibitor
    WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1. Learn More
  33. PF-04937319

    Catalog No. A13154
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    glucokinase activator
    PF-04937319 is a glucokinase activator (GKA) with EC50 value of 154.4 ?μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus. Learn More
  34. Gamitrinib TPP

    Catalog No. A13159
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    GA mitochondrial matrix inhibitor
    Gamitrinib TPP is a GA mitochondrial matrix inhibitor. Gamitrinib TPP is offered as the hexafluorophosphate salt (Cat# HY-102007A). Learn More
  35. NBTGR

    Catalog No. A13489
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    Nucleoside transport inhibitor
    NBTGR (p-Nitrobenzylthioguanosine) is a potent inhibitor of nucleoside transport; inhibits adenosine uptake with a Ki of 70 nM. Learn More
  36. Insulin levels modulator

    Catalog No. A13315
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    Insulin levels modulator could be used to treat diabetes. Learn More
  37. IDH1 Inhibitor 2

    Catalog No. A18420
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    IDH1 inhibitor
    DH1 Inhibitor 2 is a potent IDH1 inhibitor via a direct covalent modification of His315, with an IC50 of 110 nM. Learn More
  38. Asymmetric dimethylarginine

    Catalog No. A18704
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    NOS inhibitor
    Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states. Learn More
  39. KRAS G12C inhibitor 13

    Catalog No. A19041
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    KRAS G12C inhibitor
    KRAS G12C inhibitor 13 is a KRAS G12C inhibitor extracted from patent WO2018143315A1, compound 30. Learn More
  40. CHMFL-ABL-121

    Catalog No. A19079
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    ABL2 inhibitor
    CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively. Learn More
  41. GSK 366

    Catalog No. A19150
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    KMO inhibitor
    GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor with IC50s of 2.3 nM and 0.7 nM for human KMO and P. fluorescens-KMO (Pf-KMO), respectively. Learn More
  42. VP3.15

    Catalog No. A18538
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    dual PDE7/GSK-3 inhibitor
    VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). Learn More
  43. Octreotide

    Catalog No. A18284
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    Octreotide is a somatostatin analog that binds to the somatostatin receptor, mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Learn More
  44. Permethrin

    Catalog No. A18136
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    Permethrin is a widely-used pesticide of the pyrethroid family. Learn More
  45. L-Alanine

    Catalog No. A17964
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    Alanine is a non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM. Learn More
  46. Penicillin V potassium salt

    Catalog No. A17915
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    broad-spectrum penicillin antibiotic
    Penicillin V potassium is a broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms. Learn More
  47. Isoeugenol

    Catalog No. A17766
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    Isoeugenol is used in Enucleation in a Cownose Ray. Learn More
  48. MIK665

    Catalog No. A18362
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    Mcl-1 inhibitor
    MIK665 (S-64315) is a special Mcl-1 inhibitor extracted from patent WO2016207225A1, compound Preparation 13, has an IC50 of 1.81 nM. Learn More
  49. ML311

    Catalog No. A18364
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    Mcl-1/Bim interaction inhibitor
    ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction Learn More
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    MLS0315771

    Catalog No. A17219
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    MPI inhibitor
    MLS0315771 is a potent competitive phosphomannose isomerase (MPI) inhibitor. Learn More

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