Search results for 'ltx 401'

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  1. CORM-401

    Catalog No. A19938
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    CORM-401 is an oxidant-sensitive CO-releasing molecule, can be used in the research of inflammatory and oxidative stress-mediated pathologies. Learn More
  2. TCS 401

    Catalog No. A21859
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    PTP1B inhibitor
    TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). Learn More
  3. PQ 401

    Catalog No. A11951
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    IGF-1R inhibitor
    PQ 401 is a cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation. Learn More
  4. Peptide 401

    Catalog No. A13913
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    Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT). Learn More
  5. P110δ-IN-1 (ME-401)

    Catalog No. A18348
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    P110δ inhibitor
    P110δ-IN-1 is a potent and selective inhibitor of P110δ extracted from patent WO 2014055647 A1, with an IC50 of 8.4 nM. Learn More
  6. JX 401

    Catalog No. A16038
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    P38 MAPK inhibitor
    JX 401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). Learn More
  7. TCS 401 free base

    Catalog No. A15390
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    PTP1B Inhibitor
    TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively). Learn More
  8. CC-401 hydrochloride

    Catalog No. A15037
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    JNK inhibitor
    CC-401 hydrochloride is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Learn More
  9. CC-401

    Catalog No. A11352
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    JNK inhibitor
    CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Learn More
  10. DCTN2 (1-401) Human

    Catalog No. AP1005
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    Dynactin 2 (1-401 a.a.) Human Recombinant Learn More
  11. Compound 401

    Catalog No. A11778
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    DNA-PK inhibitor
    Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 μM). Learn More
  12. Roblitinib

    Catalog No. A19431
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    FGFR4 inhibitor
    Roblitinib (FGF-401; Compound Example 83) is a highly selective and potent FGFR4 inhibitor with an IC50 of 1.9 nM. Roblitinib has antitumor activity. Learn More
  13. Olodanrigan

    Catalog No. A21691
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    AT2R antagonist
    Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. Learn More
  14. ML401

    Catalog No. A18799
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    EBI2 (GPR183) antagonist
    ML401 is an antagonist of the EBI2 receptor with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity. Learn More
  15. Bardoxolone (CDDO)

    Catalog No. A11324
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    IκB/IKK inhibitor
    Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). Learn More
  16. FLTX1

    Catalog No. A22120
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    antiestrogenic properties
    FLTX1 is a fluorescent Tamoxifen derivative that can specifically label intracellular Tamoxifen-binding sites (estrogen receptors) under permeabilized and non-permeabilized conditions. FLTX1 exhibits the potent antiestrogenic properties of Tamoxifen in breast cancer cells. FLTX1 is devoid of the estrogenic agonistic effect on the uterus. Learn More
  17. Prexasertib HCl

    Catalog No. A22156
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    ATP-competitive CHK1 inhibitor
    Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L. For CHK2 and RSK, its IC50 values are 8 nM and 9 nM respectively in cell-free assay. Learn More
  18. Motixafortide

    Catalog No. A22276
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    CXCR4 antagonist
    Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC50 vakue of ??1 nM. Learn More
  19. (E)-Methyl 4-coumarate

    Catalog No. A22401
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    Antioxidant agent
    (E)-Methyl 4-coumarate (Methyl 4-hydroxycinnamate), found in several plants, such as green onion (Allium cepa) or noni (Morinda citrifolia L.) leaves. (E)-Methyl 4-coumarate cooperates with Carnosic Acid in inducing apoptosis and killing acute myeloid leukemia cells, but not normal peripheral blood mononuclear cells. Antioxidant and antimicrobial activity. Learn More
  20. Ro0711401

    Catalog No. A22511
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    mGlu1 receptor agonist
    Ro0711401 is a mGlu1 receptor agonist. Learn More
  21. IDO-IN-13

    Catalog No. A22587
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    IDO1 inhibitor
    IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an EC50 of 17 nM, extracted from patent WO2019040102A1, example 43. Learn More
  22. UNC0379 TFA

    Catalog No. A22036
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    SETD8 inhibitor
    UNC0379 TFA is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM; selective over 15 other methyltransferases. Learn More
  23. Sodium Channel inhibitor 2

    Catalog No. A20453
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    sodium channel blocker
    Sodium Channel inhibitor 2 is a sodium channel blocker extracted from patent WO 2004011439 A2, compound 3c. Learn More
  24. WAY-200070

    Catalog No. A20442
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    ERRβ agonist
    WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM. Learn More
  25. ML329

    Catalog No. A20401
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    MITF inhibitor
    ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC50 of 1.2 μM. Learn More
  26. JYL 1421

    Catalog No. A20350
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    TRPV1 receptor antagonist
    JYL 1421 is a TRPV1 receptor antagonist, with an IC50 of 8 nM. Learn More
  27. ML230

    Catalog No. A20298
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    ABCG2 inhibitor
    ML230 (CID44640177; SID 88095709) is a selective inhibitor of ATP-binding cassette (ABC) transporter ABCG2, and 36-fold selective for ABCG2 over ABCB1 with EC50s values of 0.13 μM and 4.65 μM, respectively. Learn More
  28. Fmoc-1,6-diaminohexane

    Catalog No. A19892
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    Fmoc-1,6-diaminohexane is an analog of Osw-1 which can be used to treat Alzheimer's disease and cancer, extracted from patent US 20140135279 A1. Learn More
  29. MHP

    Catalog No. A19401
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    SPHK1 activator
    MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production. MHP (Methyl caprooyl tyrosinate) enhances antimicrobial defense and innate immunity. Learn More
  30. NE 52-QQ57

    Catalog No. A19231
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    GPR4 antagonist
    NE 52-QQ57 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. Anti-inflammatory activities. Learn More
  31. Nitroaspirin

    Catalog No. A19145
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    Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Learn More
  32. HCV-IN-3

    Catalog No. A20957
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    HCV NS3/4a protein inhibitor
    HCV-IN-3 is a hepatitis C virus (HCV) NS3/4a protein inhibitor, with an IC50 of 20 μM, a Kd of 29 μM. Learn More
  33. Carotegrast

    Catalog No. A21997
    α4 integrin receptor inhibitor
    Carotegrast is an orally available α4 integrin receptor inhibitor with anti-inflammatories activities. Learn More
  34. CP-640186 hydrochloride

    Catalog No. A21808
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    ACC inhibitor
    CP-640186 hydrochloride is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Learn More
  35. Fexaramine

    Catalog No. A21771
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    FXR agonist
    Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds. Learn More
  36. ML277

    Catalog No. A21749
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    KCNQ1 potassium channel activator
    ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. Learn More
  37. Ro 28-1675

    Catalog No. A21401
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    GK activator
    Ro 28-1675 (Ro 0281675) is a potent allosteric GK activator with a SC1.5 value of 0.24?? 0.0019 uM. Learn More
  38. (S)-(-)-5-Fluorowillardiine

    Catalog No. A21337
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    AMPAR agonist
    (S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist. Learn More
  39. BMS-906024

    Catalog No. A21172
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    gamma secretase inhibitor
    BMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor. Learn More
  40. Centanafadine

    Catalog No. A21099
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    dual NE/DA transporter inhibitor
    Centanafadine is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively. Learn More
  41. Ibiglustat

    Catalog No. A21083
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    GCS inhibitor
    Ibiglustat (Venglustat), a potential therapy for PD Parkinson??s disease, SRT in Fabry??s and Gaucher??s, is a selective, allosteric inhibitor of glucosylceramide synthase (GCS) with ability to cross the blood-brain barrier. Learn More
  42. Relebactam

    Catalog No. A21071
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    diazabicyclooctane inhibitor
    Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases [ESBLs] and KPC) and class C (AmpC) enzymes. Learn More
  43. CAL-130 Racemate

    Catalog No. A20942
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    PI3Kδ inhibitor
    CAL-130 Racemate is the racemate of CAL-130. CAL-130 Racemate is a PI3Kδ inhibitor. Learn More
  44. Pyrantel tartrate

    Catalog No. A18032
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    antinematodal thiophene nicotinic receptor agonist
    Pyrantel tartrate is an antinematodal thiophene nicotinic receptor agonist and can elicit spastic muscle paralysis in parasitic worms due to prolonged activation of the excitatory nicotinic acetylcholine (nACh) receptors on body wall muscle. Learn More
  45. Flurbiprofen

    Catalog No. A10401
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    nonsteroidal anti-inflammatory agent
    Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Learn More
  46. CP-96486

    Catalog No. A12471
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    LTD4/PAF receptor antagonist
    CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively. Learn More
  47. MDRTB-IN-1

    Catalog No. A13440
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    MDRTB-IN-1 (5aα) is an antibiotic which is against Mycobacterium tuberculosis H37Rv with a MIC90 value of 10.5 μM. Learn More
  48. GSK1059865

    Catalog No. A12401
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    orexin 1 receptor antagonist
    GSK1059865 is a potent orexin 1 receptor antagonist. Learn More
  49. anti-TB agent 1

    Catalog No. A18394
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    anti-TB agent 1 is a potent and orally active anti-tuberculosis agent, with MICs of < 2 nM against the Mtb strains H37Rv, rRMP and rINH. Learn More
  50. Berberrubine chloride

    Catalog No. A12224
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    Berberrubine chloride is an active metabolite of berberine, attenuates ulcerative colitis in mice model. Learn More

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