Search results for 'mk 4305 suvorexant'

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  1. Molnupiravir

    Catalog No. A22165
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    broad-spectrum antiviral activity
    Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19. Learn More
  2. KN-93 phosphate

    Catalog No. A22229
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    membrane-permeant synthetic inhibitor
    KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II, with Ki of 370 nM. Learn More
  3. Statil

    Catalog No. A22132
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    aldose reductase inhibitor
    Ponalrestat, also known as MK-538, is an aldose reductase inhibitor. Learn More
  4. TH-263

    Catalog No. A22197
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    inactive analog control for the type III allosteric LIM-kinase (LIMK) inhibitors TH-257, TH-255 and TH-251
    TH-263 is an inactive analog control for the type III allosteric LIM-kinase (LIMK) inhibitors TH-257, TH-255 and TH-251. Learn More
  5. TH-257

    Catalog No. A22335
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    inhibitor of LIMK1 and LIMK2
    TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. Learn More
  6. Emamectin Benzoate

    Catalog No. A22417
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    nervoussystem toxicant
    Emamectin Benzoate (MK-244) is an orally active nervoussystem toxicant by binding g-aminobutyric (GABA) receptor in insects. Learn More
  7. MK-212 HCl

    Catalog No. A22531
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    MK 212 hydrochloride is a 5-HT receptor agonist; displays selectivity for 5-HT2C over 5-HT2A (IC50 values are 0.028 and 0.42 μM for human 5-HT2C and 5-HT2A receptors expressed in HEK293 cells respectively). Learn More
  8. MK-8033 hydrochloride

    Catalog No. A22011
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    dual c-Met/Ron inhibitor
    MK8033 Hcl is a novel and specific dual ATP competitive c-Met/Ron inhibitor (IC50=1 nM Wt c-Met) under investigation as a treatment for cancer. Learn More
  9. MK-0941

    Catalog No. A20823
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    allosteric glucokinase activator
    MK-0941 is a potent, orally active and allosteric glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 has potential in the treatment of type 2 diabetes. Learn More
  10. L-159282

    Catalog No. A20703
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    nonpeptide angiotensin II receptor antagonist
    L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity. Learn More
  11. Pumosetrag Hydrochloride

    Catalog No. A20692
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    5-HT3 partial agonist
    Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. Learn More
  12. Rimacalib

    Catalog No. A20690
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    CaMKII inhibitor
    Rimacalib is a Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor, with IC50s of ~1 μM for CaMKIIα to ~30 μM for CaMKIIγ. Learn More
  13. DFMTI

    Catalog No. A20558
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    mGluR1 receptors
    DFMTI is an allosteric negative modulator of mGluR1 receptors. Learn More
  14. MK-6240

    Catalog No. A20533
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    NFTs tracer
    MK-6240 is a positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs), exhibiting high specificity and selectivity for binding to NFTs. Learn More
  15. Biotin-VAD-FMK

    Catalog No. A20384
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    caspase inhibitor
    Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates. Learn More
  16. MK-3328

    Catalog No. A20379
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    β-Amyloid PET ligand
    MK-3328 is a β-Amyloid PET ligand, which exhibits high binding potency with an IC50 of 10.5 nM. Learn More
  17. Paprotrain

    Catalog No. A20346
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    MKLP-2 inhibitor
    Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM. Learn More
  18. MK-8318

    Catalog No. A20030
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    CRTh2 receptor antagonist
    MK-8318 is a potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM. Learn More
  19. VU591 hydrochloride

    Catalog No. A20009
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    ROMK inhibitor
    VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM. Learn More
  20. MK-4074

    Catalog No. A19854
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    ACC1/ACC2 inhibitor
    MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 values of approximately 3 nM. Learn More
  21. Islatravir

    Catalog No. A19638
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    Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. Learn More
  22. MKC8866

    Catalog No. A19523
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    IRE1 RNase inhibitor
    MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29?μM in human vitro. Learn More
  23. Calmidazolium chloride

    Catalog No. A19306
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    CaMK antagonist
    Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively. Also in anti-cancer research. Calmidazolium binds to CaMK with a Kd of 3 nM. Learn More
  24. Gefapixant

    Catalog No. A19254
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    P2X3R antagonist
    Gefapixant is an orally active P2X3 receptor (P2X3R) antagonist with IC50s of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Learn More
  25. Eprinomectin

    Catalog No. A21657
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    Eprinomectin(MK-397) is an avermectin selected for development as a topical endectocide; has anthelmintic, insecticidal and miticidal activity. Learn More
  26. CaMKII-IN-1

    Catalog No. A21034
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    CaMKII inhibitor
    CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM. Learn More
  27. MK-7145

    Catalog No. A21030
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    ROMK inhibitor
    MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM. Learn More
  28. BMS-3

    Catalog No. A20999
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    LIMK inhibitor
    BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively. Learn More
  29. Raltegravir potassium

    Catalog No. A21403
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    integrase (IN) inhibitor
    Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection. Learn More
  30. MK-0354

    Catalog No. A22008
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    GPR109a receptor agonist
    MK-0354 is a partial agonist of GPR109a receptor, for hGPR109a/ mGPR109a with EC50 of 1.65/1.08 μM, showed no activation of GPR109b. Learn More
  31. Rislenemdaz

    Catalog No. A21907
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    NMDA receptor GluN2B antagonist
    Rislenemdaz (CERC-301) is an orally bioavailable and selective N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B) antagonist with Ki and IC50 of 8.1 nM and 3.6 nM, respectively. Learn More
  32. Niraparib R-enantiomer

    Catalog No. A21880
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    PARP1 inhibitor
    Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM. Learn More
  33. Etoricoxib D4

    Catalog No. A21877
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    COX-2 inhibitor
    Etoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood. Learn More
  34. 1-Naphthyl PP1 hydrochloride

    Catalog No. A21790
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    Src/c-Abl inhibitor
    1-Naphthyl PP1 hydrochloride is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Learn More
  35. Taranabant ((1R,2R)stereoisomer)

    Catalog No. A21705
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    CB1 receptor inverse agonist
    Taranabant (1R,2R)stereoisomer is the R-enantiomer of Taranabant. Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist. Learn More
  36. Taranabant racemate

    Catalog No. A21699
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    CB1 antagonist/inverse agonist
    Taranabant racemate is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor extracted from patent WO 2004048317 A1. Learn More
  37. Ubrogepant

    Catalog No. A21670
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    CGRP antagonist
    Ubrogepant (MK-1602) is a novel oral calcitonin gene-related peptide receptor (CGRP) antagonist in development for acute treatment of migraine. Learn More
  38. MK2-IN-1 hydrochloride

    Catalog No. A21662
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    MAPKAPK2(MK2) inhibitor
    MK2-IN-1 hydrochloride is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode. Learn More
  39. MKC9989

    Catalog No. A21602
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    Hydroxy aryl aldehydes (HAA) inhibitor
    MKC9989 is a Hydroxy aryl aldehydes (HAA) inhibitor and also inhibits IRE1α with an IC50 of 0.23 to 44 μM. Learn More
  40. Serlopitant

    Catalog No. A21582
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    Neurokinin-1 (NK-1) receptor antagonist
    Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist. Learn More
  41. MK-0674

    Catalog No. A21558
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    cathepsin K inhibitor
    MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S. Learn More
  42. Finasteride acetate

    Catalog No. A21537
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    testosterone 5-alpha-reductase inhibitor
    Finasteride (acetate) is an orally active testosterone 5-alpha-reductase inhibitor. Learn More
  43. MK-4256

    Catalog No. A21510
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    SSTR3 antagonist
    MK-4256 is a potent and selective SSTR3 antagonist with IC50s of 0.66 nM and 0.36 nM in human and mouse receptor binding assays, respectively. Learn More
  44. VU591

    Catalog No. A21362
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    potassium channel inhibitor
    VU591 is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM. Learn More
  45. Amicarbazone

    Catalog No. A21294
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    photosynthetic electron transport inhibitor
    Amicarbazone(BAY-MKH3586; BAY314666) is a potent inhibitor of photosynthetic electron transport via binding to the Qb domain of photosystem II (PSII); herbicide with a broad spectrum of weed control. Learn More
  46. MK-0557

    Catalog No. A21271
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    neuropeptide Y5 receptor antagonist
    MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM. Learn More
  47. Impurity F of Calcipotriol

    Catalog No. A21215
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    Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. Learn More
  48. MK-5046

    Catalog No. A21214
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    BRS-3 agonist
    MK-5046 is a novel BRS-3 agonist, binds to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM). Learn More
  49. MK-0429

    Catalog No. A21173
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    αvβ3 integrin antagonist
    MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide αvβ3 integrin antagonist with an IC50 of 80 nM. Learn More
  50. Relebactam

    Catalog No. A21071
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    diazabicyclooctane inhibitor
    Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases [ESBLs] and KPC) and class C (AmpC) enzymes. Learn More

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