Search results for 'pb 22'

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  1. Remimazolam

    Catalog No. A22200
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    benzodiazepine derivative drug
    Remimazolam, also known as CNS-7056, is a benzodiazepine derivative drug, developed by PAION, in collaboration with Japanese licensee Ono Pharmaceutical as an alternative to the short-acting imidazobenzodiazepine midazolam, for use in induction of anaesthesia and conscious sedation for minor invasive procedures. Learn More
  2. Pemafibrate

    Catalog No. A22201
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    PPAR alpha agonist
    Pemafibrate, also known as (R)-K 13675, is a PPAR alpha agonist. Learn More
  3. Avacopan

    Catalog No. A22202
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    selective C5aR antagonist
    Avacopan (CCX168) is an orally administered and selective C5a receptor (C5aR) antagonist. Learn More
  4. SEL24-B489 HCl

    Catalog No. A22203
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    pan-PIM/FLT3 inhibitor
    SEL24-B489 HCl is a potent, dual pan-PIM/FLT3 inhibitor. Learn More
  5. Perlapine

    Catalog No. A22204
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    hM3Dq DREADD agonist
    Perlapine is a potent and selective hM3Dq DREADD agonist (EC50 = 2.8 nM). This drug exhibits >10,000-fold selectivity for hM3Dq over hM3. Learn More
  6. Emedastine

    Catalog No. A22158
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    histamine H1 receptor antagonist
    Emedastine is an orally active, selective and high affinity histamine H1 receptor antagonist with a Ki value of 1.3 nM. Learn More
  7. IACS-13909

    Catalog No. A22159
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    SHP2 allosteric inhibitor
    IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. Learn More
  8. CB-103

    Catalog No. A22160
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    protein-protein interaction (PPI) inhibitor
    CB-103 is a first-in-class, orally active protein-protein interaction (PPI) inhibitor of the NOTCH transcriptional activation complex. CB-103 has anti-tumor activity. Learn More
  9. CRBN modulator-1

    Catalog No. A22161
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    CRBN modulator
    CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM. Learn More
  10. ATR inhibitor 2

    Catalog No. A22162
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    ATR inhibitor
    ATR inhibitor 2 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. Learn More
  11. JSH-150

    Catalog No. A22164
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    CDK9 inhibitor
    JSH-150 is a highly selective and potent CDK9 inhibitor with an IC50 of 1 nM. Learn More
  12. Molnupiravir

    Catalog No. A22165
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    broad-spectrum antiviral activity
    Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19. Learn More
  13. Laninamivir octanoate

    Catalog No. A22166
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    neuraminidase (NA) inhibitor
    Laninamivir octanoate (CS-8958), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Learn More
  14. Conoidin A

    Catalog No. A22167
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    cell permeable inhibitor
    Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII). Learn More
  15. ML382

    Catalog No. A22168
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    MRGPRX1 positive allosteric modulator
    ML382 is a potent and selective MRGPRX1 (Mas-related G protein-coupled receptor X1, MrgX1) positive allosteric modulator, with an EC50 of 190 nM. Learn More
  16. GRP-60367

    Catalog No. A22169
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    rabies virus (RABV) entry inhibitor
    GRP-60367 is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. Learn More
  17. Lycorine

    Catalog No. A22170
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    SCAP inhibitor
    Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Learn More
  18. Eurycomanone

    Catalog No. A22171
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    Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis. Learn More
  19. Gentiopicroside

    Catalog No. A22172
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    antianti-inflammatoryand antioxidative effects
    Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 ?M and 22.8 ?M for CYP2A6; Gentiopicroside has antianti-inflammatoryand antioxidative effects. Learn More
  20. Eleutheroside B1

    Catalog No. A22173
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    anti-human influenza virus efficacy
    Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50 value of 64-125 ?g/ml. Antiviral and anti-inflammatory activities. Learn More
  21. Periplogenin

    Catalog No. A22174
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    anti-psoriatic agent
    Periplogenin is a naturally occurring furanocoumarin found in Angelica dahurica roots, with potent anti-psoriatic effects. Periplogenin induces adipocyte differentiation. Learn More
  22. Oxyberberin

    Catalog No. A22175
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    natural alkaloid
    Berlambine is a natural alkaloid isolated from many plants. Learn More
  23. Groenlandicine

    Catalog No. A22176
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    protoberberine alkaloid
    Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR). Learn More
  24. 6-Methoxydihydroavicine

    Catalog No. A22177
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    antiplatelet activities
    6-Methoxydihydroavicine is an alkaloid isolated from Zanthoxylum integrifoliolum. 6-Methoxydihydroavicine has antiplatelet activities and inhibits AA-, collagen- and PAF-induced platelet aggregation in vitro. Learn More
  25. S-23

    Catalog No. A22178
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    selective androgen receptor modulator
    S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. Learn More
  26. AC-262536

    Catalog No. A22179
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    selective androgen receptor (SAR) molecule
    AC-262536 is a selective androgen receptor (SAR) molecule. It has partial agonist activity with respect to testosterone and suppresses luteinizing hormone. Learn More
  27. NSC23005 free acid

    Catalog No. A22180
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    p18INK inhibitor
    NSC23005 is a p18INK inhibitor. NSC23005 potently promotes hematopoietic stem cell (HSC) expansion (ED50 = 5.21 nM). Learn More
  28. MQAE

    Catalog No. A22181
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    fluorescent indicator
    MQAE is a fluorescent indicator that is quenched via collision with chloride, and is more sensitive and selective than 36Cl and microelectrode-based methods for chloride measurement in cells. Learn More
  29. ML346

    Catalog No. A22182
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    activator of Hsp70 expression and HSF-1 activity
    ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC50 of 4.6 μM for Hsp70. Learn More
  30. ALK2-IN-1

    Catalog No. A22183
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    inhibitor of Activin receptor-like kinase (ALK2) mutant R206H
    ALK2-IN-1 (BLU-782) is a potent and selective inhibitor of Activin receptor-like kinase (ALK2) mutant R206H with binding IC50 of <10 nM. Learn More
  31. OTSSP167 hydrochloride

    Catalog No. A22184
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    MELK inhibitor
    OTSSP167 (hydrochloride) is a highly potent MELK inhibitor with IC50 value of 0.41 nM. Learn More
  32. BIO-013077-01

    Catalog No. A22185
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    antagonist of the TGFbeta family type I receptors, Alk5 and/or Alk4
    BIO-013077-01, Novel potent antagonist of the TGFbeta family type I receptors, Alk5 and/or Alk4. Learn More
  33. Practolol

    Catalog No. A22186
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    β1-adrenergic receptor antagonist
    Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias. Learn More
  34. Thiambutosine

    Catalog No. A22187
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    candidate for treatment of lepromatous leprosy
    Thiambutosine was a candidate for treatment of lepromatous leprosy. Learn More
  35. SSD114 hydrochloride

    Catalog No. A22188
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    GABAB receptor positive allosteric modulator
    SSD114 hydrochloride is a novel GABAB receptor positive allosteric modulator. Learn More
  36. GR 125743

    Catalog No. A22189
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    5-HT1B/1D receptor antagonis
    GR 125743 is a selective 5-HT1B/1D receptor antagonist, with pKis of 8.85 and 8.31 for wild-type h5-HT1B and wild-type h5-HT1D, respectively. Learn More
  37. Isocyclosporin A

    Catalog No. A22205
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    Isocyclosporin A is a rearranged degradation product formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions. Learn More
  38. Levobupivacaine hydrochloride

    Catalog No. A22206
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    sodium channel blocker
    Levobupivacaine hydrochloride is a sodium channel blocker. Learn More
  39. Apcin-A

    Catalog No. A22207
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    anaphase-promoting complex (APC) inhibitor
    Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Learn More
  40. ICCB280

    Catalog No. A22208
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    inducer of C/EBPα
    ICCB280 is a potent inducer of C/EBPα. Learn More
  41. SBP-7455

    Catalog No. A22209
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    dual ULK1/ULK2 autophagy inhibitor
    SBP-7455 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. Learn More
  42. FIDAS-5

    Catalog No. A22210
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    MAT2A inhibitor
    FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. Learn More
  43. Cholesterol

    Catalog No. A22211
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    endogenous estrogen-related receptor α (ERRα) agonist
    Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist. Learn More
  44. Orelabrutinib

    Catalog No. A22225
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    BTK inhibitor
    Orelabrutinib (ICP-022) is a potent, orally active, and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Learn More
  45. Dextromethorphan

    Catalog No. A22212
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    antitussive drug
    Dextromethorphan (Discontinued) (DXM or DM) is an antitussive (cough suppressant) drug of the morphinan class with sedative and dissociative properties. Learn More
  46. Vacuolin-1

    Catalog No. A22213
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    cell-permeable lysosomal exocytosis inhibitor
    Vacuolin-1 is a potent and cell-permeable lysosomal exocytosis inhibitor. Learn More
  47. VLX600

    Catalog No. A22214
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    iron-chelating inhibitor
    VLX600 is an iron-chelating inhibitor of oxidative phosphorylation (OXPHOS). Learn More
  48. Theliatinib

    Catalog No. A22215
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    EGFR inhibitor
    Theliatinib (HMPL-309) is a potent, ATP-competitive, orally active and highly selective EGFR inhibitor with a Ki of 0.05 nM and an IC50 of 3 nM. Learn More
  49. Ticlopidine

    Catalog No. A22216
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    inhibitor of platelet aggregation
    Ticlopidine (Yuclid, Ticlopidinum, Ticlopidina) is an orally active inhibitor of platelet aggregation induced by adenosine diphosphate (ADP). Learn More
  50. S29434

    Catalog No. A22217
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    inhibitor of quinone reductase 2 (QR2)
    S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. Learn More

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