Search results for 'pri 724'

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  1. 24R-Calcipotriol

    Catalog No. A21213
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    24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. Learn More
  2. Arrhythmias-Targeting Compound 1

    Catalog No. A19464
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    Arrhythmias-Targeting Compound 1 is used in the research of arrhythmias, extracted from patent WO 2001028992 A2. Learn More
  3. Imidacloprid-urea

    Catalog No. A22253
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    marine xenobiotic metabolite
    Imidacloprid-urea with a role as a marine xenobiotic metabolite, is the primary imidacloprid soil metabolite, whereas imidacloprid-olefin is the main plant-relevant metabolite and is more toxic to insects than imidacloprid. Learn More
  4. Triphala

    Catalog No. A16067
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    Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities
    Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica. Triphala inhibits NF-κB activation. Triphala exerts antifungal action. Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities. Learn More
  5. Cetraxate Hydrochloride

    Catalog No. A22155
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    mucosal protective agent and an anti-ulcer drug
    Cetraxate (DV-1006) Hydrochloride (HCl) is a mucosal protective agent and an anti-ulcer drug candidate. Cetraxate raises levels of calcitonin gene-related peptide and substance P in human plasma. Learn More
  6. BTK inhibitor 1 (Compound 27)

    Catalog No. A22445
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    BTK inhibitor
    BTK inhibitor 1 (compound 27) is an inhibitor of BTK with an IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM. Learn More
  7. Merafloxacin

    Catalog No. A22483
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    Merafloxacin, also known as CI 934, is a fluoroquinolone antibacterial, which was also identified as a ?1 PRF inhibitor of SARS-CoV-2. Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on ?1 PRF of other beta coronaviruses. Importantly, frameshift inhibition by merafloxacin substantially impedes SARS-CoV-2 replication in Vero E6 cells, thereby providing the proof of principle of targeting ?1 PRF as an effective antiviral strategy for SARS-CoV-2. Learn More
  8. Leteprinim

    Catalog No. A22613
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    neurotrophic agent
    Leteprinim, also known as AIT-082 and SPI-205, is a neurotrophic agent potentially for the treatment of Alzheimer's disease, and spinal cord injury. Learn More
  9. Acecainide HCl

    Catalog No. A22660
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    Class III antiarrhythmic agent
    Acecainide, also known as N-acetylprocainamide and ASL 601, is the N-acetylated metabolite of procainamide. Acecainide is a Class III antiarrhythmic agent. It can be given either intravenously or orally, and is eliminated primarily by renal excretion. Learn More
  10. Oleanolic acid derivative 1

    Catalog No. A22022
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    Oleanolic acid derivative 1 is an oleanolic acid derivative, which is a novel triterpenoid-steroid hybrid molecule. Learn More
  11. Pridopidine

    Catalog No. A22009
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    D2R antagonist
    Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Learn More
  12. beta-lactamase-IN-1

    Catalog No. A20784
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    beta-lactamase-IN-1 targets Neisseria gonorrhoeae infection which comprises administering to a subject in need thereof novel Tricyclic nitrogen containing compounds and corresponding pharmaceutical compositions as described herein. Learn More
  13. Duocarmycin MA

    Catalog No. A20738
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    antibody drug conjugates (ADCs) toxin
    Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-drug resistant cell lines. Learn More
  14. PK 11195

    Catalog No. A20724
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    Dual MDM2/TSPO Inhibitor
    PK 11195 is a 2?Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitor, and is potentially useful for the Treatment of Gliomas. Learn More
  15. Sultopride

    Catalog No. A20663
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    dopamine D2 receptor antagonist
    Sultopride (LIN-1418) is a selective antagonist of dopamine D2 receptor. Learn More
  16. 5-FAM

    Catalog No. A20660
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    fluorescent derivatization reagent
    5-FAM (5-Carboxyfluorescein) contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid. Fluorescein is the most common fluorescent derivatization reagent for labeling biomolecules. Learn More
  17. PrPSc-IN-1

    Catalog No. A20488
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    PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrPSc, inhibits its accumulation, with an IC50 of 1.6 μM. Anti-prion activity. Learn More
  18. TAK-243

    Catalog No. A20369
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    UAE (UBA1) inhibitor
    TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. Learn More
  19. Iclaprim

    Catalog No. A20367
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    Dihydrofolate inhibitor
    Iclaprim is a new selective bacterial Dihydrofolate inhibitor, which can inhibit the growth of S. aureus (MRSA) with an MIC90 of 0.06 μg/mL. Learn More
  20. Trimethoprim 3-oxide

    Catalog No. A20361
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    Trimethoprim 3-oxide (Trimethoprim 3-N-oxide) is the primary metabolite of trimethoprim. Learn More
  21. Rentiapril

    Catalog No. A20233
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    ACE inhibitor
    Rentiapril is an orally active angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Learn More
  22. Utibapril

    Catalog No. A19907
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    ACE inhibitor
    Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activities. Learn More
  23. PROTAC RAR Degrader-1

    Catalog No. A19757
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    RAR degrader
    PROTAC RAR Degrader-1 comprises a cIAP1 ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Learn More
  24. KDM2A/7A-IN-1

    Catalog No. A19724
    KDM2A/7A inhibitor
    KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16?μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases. Learn More
  25. Desisobutyryl-ciclesonide

    Catalog No. A19718
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    Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. Desisobutyryl-ciclesonide has affinity for the glucocorticoid receptor. Learn More
  26. PROTAC ERα Degrader-2

    Catalog No. A19697
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    ERα degrader
    PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Learn More
  27. PROTAC AR Degrader-4

    Catalog No. A19678
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    AR degrader
    PROTAC AR Degrader-4 comprises a cIAP1 ligand binding group, a linker and an androgen receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Learn More
  28. Avapritinib

    Catalog No. A19505
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    KIT and PDGFRA inhibitor
    Avapritinib (BLU-285) is a highly potent, selective, and orally bioavailable KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Learn More
  29. NCX899

    Catalog No. A19352
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    ACE inhibitor
    NCX899 is a NO-releasing derivative of enalapril, and shows inhibitory activity against angiotensin-converting enzyme (ACE) activity. Learn More
  30. Raclopride

    Catalog No. A19204
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    dopamine D2/D3 receptor antagonist
    Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively. Learn More
  31. Eprinomectin

    Catalog No. A21657
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    Eprinomectin(MK-397) is an avermectin selected for development as a topical endectocide; has anthelmintic, insecticidal and miticidal activity. Learn More
  32. d-Atabrine dihydrochloride

    Catalog No. A21654
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    d-Atabrine dihydrochloride is an active enantiomer of quinacrine which displays antiprion activity. Learn More
  33. Luminol

    Catalog No. A21326
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    Luminol(Diogenes reagent) is a versatile chemical that exhibits chemiluminescence, with a striking blue glow, when mixed with an appropriate oxidizing agent. Learn More
  34. Ulipristal acetate

    Catalog No. A21041
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    progesterone receptor modulator
    Ulipristal (acetate) is a novel selective progesterone receptor modulator (SPRM) for the treatment of benign gynecological conditions such as uterine myoma. Learn More
  35. Veledimex

    Catalog No. A21011
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    CYP3A4/5 inhibitor and substrate
    Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5. Learn More
  36. Indotecan

    Catalog No. A20979
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    Top1 inhibitor
    Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Learn More
  37. Amisulpride hydrochloride

    Catalog No. A21994
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    dopamine D2/D3 receptor antagonist
    Amisulpride hydrochloride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively. Learn More
  38. Olprinone

    Catalog No. A21869
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    PDE3 inhibitor
    Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. Learn More
  39. NM107

    Catalog No. A21761
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    HCV NS5B polymerase inhibitor
    NM107 (2'-C-Methylcytidine) is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, the EC50 of NM107 in the wild-type replicon cells is 1.85 μM. Learn More
  40. TTA-Q6(isomer)

    Catalog No. A21724
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    T-type Ca2+ channel antagonist
    TTA-Q6(isomer) is an isomer of TTA-Q6. TTA-Q6 is a selective T-type Ca2+ channel antagonist. Learn More
  41. l-Atabrine dihydrochloride

    Catalog No. A21646
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    l-Atabrine dihydrochloride is a less active enantiomer of quinacrine which displays antiprion activity. Learn More
  42. Prinomastat

    Catalog No. A21501
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    metalloproteinase inhibitor
    Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. Learn More
  43. N-Desmethyl Clomipramine D3 hydrochloride

    Catalog No. A21369
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    N-Desmethyl Clomipramine D3 hydrochloride is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine'. Learn More
  44. Cisapride

    Catalog No. A21340
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    hERG potassium channel inhibitor
    Cisapride(R 51619) is a nonselective 5-HT4 receptor agonist, it is also a potent hERG potassium channel inhibitor. Learn More
  45. 5(6)-FAM SE

    Catalog No. A21295
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    amine-reactive green fluorescent dye
    5(6)-FAM SE is an amine-reactive green fluorescent dye widely used for labeling proteins or other molecules that contain a primary or secondary aliphatic amine. Learn More
  46. Prinaberel

    Catalog No. A21255
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    ERbeta agonist
    Prinaberel(ERB-041) is a potent and selective ERbeta agonist; being >200-fold selective for ERbeta. Learn More
  47. CE-224535

    Catalog No. A21183
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    P2X7 receptor antagonist
    CE-224535 is a selective P2X7 receptor antagonist. Learn More
  48. 5(6)-Carboxyfluorescein

    Catalog No. A21120
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    5(6)-Carboxyfluorescein contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid; cell-impermeant 5,6-FAM can also be used as a nonfixable polar tracer to investigate fusion, lysis and gap-junctional communication and to detect changes in cell or liposome volume. Learn More
  49. Valifenalate

    Catalog No. A21111
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    Valifenalate(IR5885; Valiphenal), which is approved for application on high-value crops such as grapes, tomatoes and other vegetables, is effective against various types of mildew and is currently marketed primarily under the Valis moniker; insecticide agent. Learn More
  50. 5(6)-TAMRA

    Catalog No. A21104
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    5(6)-TAMRA contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid; bright, orange-fluorescent dye produces conjugates with absorption/emission maxima of ~555/580 nm. Learn More

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