Search results for 'rac nedisertib'

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  1. (Rac)-AZD 6482

    Catalog No. A20629
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    p110β inhibitor
    Rac)-AZD 6482 ((Rac)-KIN-193) is a less active racemate of AZD 6482. AZD 6482 is a potent and selective p110β inhibitor with an IC50 of 0.69 nM. Learn More
  2. (Rac)-Benpyrine

    Catalog No. A22192
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    TNF-α inhibitor
    (Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research. Learn More
  3. (Rac)-JBJ-04-125-02

    Catalog No. A22141
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    EGFR inhibitor
    (Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M. Learn More
  4. rac-BHFF

    Catalog No. A22659
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    GABAB receptor agonist
    rac-BHFF is a selective GABAB receptor agonist. Learn More
  5. (Rac)-VU 6008667

    Catalog No. A21939
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    mAChR M5 negative allosteric modulator
    (Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration. Learn More
  6. (Rac)-BAY1238097

    Catalog No. A21598
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    BET inhibitor
    (Rac)-BAY1238097 is a BET inhibitor, with an IC50 of 1.02 μM for BRD4. Used in cancer research. Learn More
  7. (Rac)-PT2399

    Catalog No. A21376
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    HIF-2α inhibitor
    (Rac)-PT2399 (Compound 10e), the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a (HIF-2α) inhibitor with an IC50 of 0.01 μM. Learn More
  8. (Rac)-TMP778

    Catalog No. A19996
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    RORγt inverse agonist
    (Rac)-TMP778 is the racemate of TMP778. TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay. Learn More
  9. (Rac)-Antineoplaston A10

    Catalog No. A21689
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    Ras inhibitor
    (rac)-Antineoplaston A10 is the racemate of Antineoplaston A10. Antineoplaston A10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer. Learn More
  10. rac-Rotigotine Hydrochloride

    Catalog No. A15217
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    D2 receptor agonist
    rac-Rotigotine Hydrochloride is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM. Learn More
  11. EHop-016

    Catalog No. A12740
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    Rac GTPase Inhibitor
    EHop-016 is a potent and specific inhibitor of Rac1 and Rac3 GTPase activity that inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration. Learn More
  12. MBQ-167

    Catalog No. A16808
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    Dual inhibitor of Rac and Cdc42
    MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells. Learn More
  13. NSC-23766 HCl

    Catalog No. A13975
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    Rac GTPase inhibitor
    NSC 23766 is a cell-permeable, reversible inhibitor of Rac1 activation by the Rac-specific GEFs TrioN and Tiam 1 (IC50 = 50 uM). Learn More
  14. EHT 1864

    Catalog No. A13886
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    Rac family GTPase inhibitor
    EHT 1864 is an antiproliferative chemical shown to inhibit Rac family GTPases. Learn More
  15. 1-Linoleoyl Glycerol

    Catalog No. A17081
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    1-Linoleoyl glycerol (1-LG) is a fatty acid glycerol that has been isolated from S. chinensis roots. It inhibits PAF-AH with an IC50 of 45 μM. Learn More
  16. NSC 23766

    Catalog No. A12546
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    Rac1 activation inhibitor
    NSC 23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 μM) without affecting Cdc42 or RhoA activation. Learn More
  17. CB-103

    Catalog No. A22160
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    protein-protein interaction (PPI) inhibitor
    CB-103 is a first-in-class, orally active protein-protein interaction (PPI) inhibitor of the NOTCH transcriptional activation complex. CB-103 has anti-tumor activity. Learn More
  18. CRBN modulator-1

    Catalog No. A22161
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    CRBN modulator
    CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM. Learn More
  19. Lycorine

    Catalog No. A22170
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    SCAP inhibitor
    Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Learn More
  20. Practolol

    Catalog No. A22186
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    β1-adrenergic receptor antagonist
    Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias. Learn More
  21. Dextromethorphan

    Catalog No. A22212
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    antitussive drug
    Dextromethorphan (Discontinued) (DXM or DM) is an antitussive (cough suppressant) drug of the morphinan class with sedative and dissociative properties. Learn More
  22. DS-1001b

    Catalog No. A22236
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    mutant IDH-1 inhibitor
    DS-1001b is a mutant IDH-1 (Isocitrate Dehydrogenase-1) inhibitor extracted from patent WO2016052697A1, Example 168, and has antitumor activity. Learn More
  23. VTP50469

    Catalog No. A22238
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    Menin-MLL interaction inhibitor
    VTP50469 is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. VTP50469 has potently anti-leukemia activity. Learn More
  24. ML254

    Catalog No. A22242
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    Positive Allosteric Modulators (PAMs)
    ML-254, also known as VU0430644; is Positive Allosteric Modulators (PAMs) of mGlu5 with Competitive MPEP-Site Interaction. Learn More
  25. Enocyanin

    Catalog No. A18660
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    anthocyanin extracted from grapes
    Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity. Learn More
  26. LC3-mHTT-IN-AN1

    Catalog No. A22054
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    mHTT-LC3 linker compound
    LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. Learn More
  27. BMS-1001

    Catalog No. A22061
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    PD-1/PD-L1 interaction inhibitor
    BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. Learn More
  28. BAY 2416964

    Catalog No. A22067
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    aryl hydrocarbon receptor (AHR) antagonist
    BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment. Learn More
  29. DiZPK

    Catalog No. A22069
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    DiZPK is a photocrosslinker for identifying direct protein-protein interactions in living prokaryotic and eukaryotic cells. Learn More
  30. RO2959 hydrochloride

    Catalog No. A22085
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    CRAC channel inhibitor
    RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. Learn More
  31. RO5203648 hydrochloride

    Catalog No. A22118
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    partial agonist of Trace amine-associated receptor 1
    RO5203648 hydrochloride is a partial agonist of Trace amine-associated receptor 1 (TAAR1). Learn More
  32. FLTX1

    Catalog No. A22120
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    antiestrogenic properties
    FLTX1 is a fluorescent Tamoxifen derivative that can specifically label intracellular Tamoxifen-binding sites (estrogen receptors) under permeabilized and non-permeabilized conditions. FLTX1 exhibits the potent antiestrogenic properties of Tamoxifen in breast cancer cells. FLTX1 is devoid of the estrogenic agonistic effect on the uterus. Learn More
  33. GNE-140 racemic

    Catalog No. A22146
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    lactate dehydrogenase (LDHA) inhibitor
    GNE-140 racemic is a novel potent lactate dehydrogenase (LDHA) inhibitor. Learn More
  34. Enpp-1-IN-1

    Catalog No. A22194
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    Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitor
    Enpp-1-IN-1 is a Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitor extracted from patent WO2019046778, Example 55. Learn More
  35. RGD peptide (GRGDNP)

    Catalog No. A22271
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    integrin-ligand interactions inhibitor
    RGD peptide (GRGDNP) acts as an inhibitor of integrin-ligand interactions and plays an important role in cell adhesion, migration, growth, and differentiation. Learn More
  36. GSK2983559 free acid

    Catalog No. A22272
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    RIP2 kinase inhibitor
    GSK2983559 free acid (compound 3) is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor. Learn More
  37. Amarogentin

    Catalog No. A22286
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    bitter taste receptor TAS2R1 agonist
    Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. Learn More
  38. Tomatine

    Catalog No. A22293
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    precipitating agent
    Tomatine is an glycoalkaloid that occurs in the extract of leaves of wild tomato plants. It has been found to inhibit the growth of various fungi and bacteria. It is used as a precipitating agent for steroids. Learn More
  39. Lavendustin B

    Catalog No. A22298
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    GLUT1 inhibitor
    Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 ?M. Lavendustin B is also a weak inhibitor of tyrosine kinases. Learn More
  40. Gallein

    Catalog No. A22304
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    Gβγ subunit signalling inhibitor
    Gallein is a G protein βγ (Gβγ) subunit signalling inhibitor. Gallein disrupts the interaction of Gβγ subunits with the PI3Kγ. Anticancer agent. Learn More
  41. L-Quebrachitol

    Catalog No. A22312
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    natural product
    L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway. Learn More
  42. Loureirin A

    Catalog No. A22313
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    Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity. Learn More
  43. MCP110

    Catalog No. A22317
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    inhibitor of Ras/Raf-1 interaction
    MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf. MCP110 disrupts this interaction might can be used for the research of human tumors. Learn More
  44. IRAK4-IN-4

    Catalog No. A22333
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    IRAK4 inhibitor
    IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. Learn More
  45. BMP signaling agonist sb4

    Catalog No. A22362
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    BMP4 signaling agonist
    BMP signaling agonist sb4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM, activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. Learn More
  46. NSC12

    Catalog No. A22374
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    antitumor agent
    NSC12 (NSC 172285) is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity. Learn More
  47. Sophocarpine monohydrate

    Catalog No. A22386
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    anti-tumor agent
    Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Learn More
  48. Methylthiouracil

    Catalog No. A22393
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    antithyroid agent
    Methylthiouracil is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2. Learn More
  49. 2,3-Butanedione-2-monoxime

    Catalog No. A22395
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    inhibitor of skeletal muscle myosin-II
    2,3-Butanedione monoxime (BDM, Diacetyl monoxime, Diacetylmonoxime) is the well-characterized, low-affinity, non-competitive inhibitor of skeletal muscle myosin-II and inhibits skeletal and cardiac muscle contraction. Learn More
  50. Ginsenoside Re

    Catalog No. A22398
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    antiinflammation agent
    Ginsenoside Re (Ginsenoside B2) is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB. Learn More

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