Search results for 'sar 100842'

Items 1 to 50 of 163 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4

Set Ascending Direction
  1. SAR-020106

    Catalog No. A22371
    Quick View
    CHK1 inhibitor
    SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13.3 nM for human CHK1. Learn More
  2. SAR-20347

    Catalog No. A20380
    Quick View
    TYK2/JAK1/JAK2/JAK3 inhibitor
    SAR-20347 is an inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50s of 0.6, 23, 26 and 41 nM, respectively. Learn More
    • New

    SAR-7334 HCl

    Catalog No. A17237
    Quick View
    TRPC6 inhibitor
    SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected. Learn More
  3. Lifitegrast

    Catalog No. A17299
    Quick View
    LFA-1 antagonist
    Lifitegrast (SAR 1118) is an integrin lymphocyte function-associated antigen-1 (LFA-1) antagonist; inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Learn More
  4. AC-262536

    Catalog No. A22179
    Quick View
    selective androgen receptor (SAR) molecule
    AC-262536 is a selective androgen receptor (SAR) molecule. It has partial agonist activity with respect to testosterone and suppresses luteinizing hormone. Learn More
  5. SAR439859

    Catalog No. A22501
    Quick View
    SAR439859 is an orally available, nonsteroidal selective estrogen receptor degrader/downregulator (SERD). Learn More
  6. Mavacamten

    Catalog No. A19326
    Quick View
    cardiac myosin modulator
    Mavacamten is a modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively. Learn More
  7. SAR405 R enantiomer

    Catalog No. A21410
    Quick View
    PIK3C3/Vps34 inhibitor
    SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is a PIK3C3/Vps34 inhibitor. Learn More
  8. SAR405

    Catalog No. A21345
    Quick View
    PI3KC3 isoform Vps34 inhibitor
    SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PI3KC3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM). Learn More
  9. SAR125844

    Catalog No. A21094
    Quick View
    MET inhibitor
    SAR125844 is a potent, highly selective, reversible and ATP-competitive MET receptor tyrosine kinase (RTK) inhibitor, with an IC50 of 4.2 nM. Shows inhibition of MET autophosphorylation in cell-based assays. Learn More
  10. Ibiglustat

    Catalog No. A21083
    Quick View
    GCS inhibitor
    Ibiglustat (Venglustat), a potential therapy for PD Parkinson??s disease, SRT in Fabry??s and Gaucher??s, is a selective, allosteric inhibitor of glucosylceramide synthase (GCS) with ability to cross the blood-brain barrier. Learn More
  11. SAR7334

    Catalog No. A20836
    Quick View
    TRPC6 inhibitor
    SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM. Learn More
  12. SAR260301

    Catalog No. A16877
    Quick View
    PI3Kβ inhibitor
    SAR260301 is potent and selective Class I phosphatidylinositol-3-kinase (PI3K)β specific inhibitor with an IC50 of 52 nM for this isoform. Learn More
  13. SAR245409 (XL765, Voxtalisib)

    Catalog No. A16276
    Quick View
    PI3K/mTOR dual inhibitor
    SAR245409 is a PI3K/mTOR dual kinase inhibitor XL765 is an orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Learn More
  14. SAR407899 HCl

    Catalog No. A15921
    Quick View
    ROCK inhibitor
    SAR407899 is a potent and selective Rho kinase inhibitor with promising antihypertensive activity. Learn More
  15. XL-147 (Pilaralisib)

    Catalog No. A15283
    Quick View
    PI3K Inhibitor
    XL147 is a potent, orally bioavailable inhibitor of the class I PI3K family of lipid kinases. Learn More
  16. SAR156497

    Catalog No. A14382
    Aurora Kinase inhibitor
    SAR156497 is an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy with IC50 = 0.5 nM (Aurora A), 1 nM (Aurora B / incenp), 3 nM (Aurora C / incenp) respectively SAR156497 combines high in vitro potency with satisfactory metabolic stability and limited CYP3A4 and PDE3 inhibition. Learn More
  17. Molnupiravir

    Catalog No. A22165
    Quick View
    broad-spectrum antiviral activity
    Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19. Learn More
  18. S-23

    Catalog No. A22178
    Quick View
    selective androgen receptor modulator
    S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. Learn More
  19. VK-II-36

    Catalog No. A22243
    Quick View
    carvedilol analog
    VK-II-36 is a carvedilol analog that suppresses sarcoplasmic reticulum (SR) Ca(2+) release but does not block the β-receptor. Learn More
  20. XP-59

    Catalog No. A22053
    Quick View
    SARS-CoV Mpro inhibitor
    XP-59 is a potent inhibitor of the SARS-CoV Mpro, with a Ki of 0.1 μM. Learn More
  21. FOY 251

    Catalog No. A22196
    Quick View
    proteinase inhibitor
    FOY 251, an anti-proteolytic active metabolite Camostate (HY-13512), acts as a proteinase inhibitor. FOY 251 inhibits SARS-CoV-2 infection in cells assay. Learn More
  22. Beta-asarone

    Catalog No. A22354
    Quick View
    neuroprotection agent
    Beta-Asarone, found in certain plants such as Acorus and Asarum, could pass the blood-brain barrier and exerts neuroprotection effects. Learn More
  23. Merafloxacin

    Catalog No. A22483
    Quick View
    Merafloxacin, also known as CI 934, is a fluoroquinolone antibacterial, which was also identified as a ?1 PRF inhibitor of SARS-CoV-2. Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on ?1 PRF of other beta coronaviruses. Importantly, frameshift inhibition by merafloxacin substantially impedes SARS-CoV-2 replication in Vero E6 cells, thereby providing the proof of principle of targeting ?1 PRF as an effective antiviral strategy for SARS-CoV-2. Learn More
  24. Sardomozide

    Catalog No. A22031
    Quick View
    SAMDC inhibitor
    Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM. Learn More
  25. Elisartan

    Catalog No. A20697
    Quick View
    Elisartan is an orally active non-peptide pro-drug of angiotensin II AT1 receptor antagonist HN-12206, and shows anti-hypertension activities. Learn More
  26. Saroglitazar

    Catalog No. A20636
    Quick View
    PPAR agonist
    Saroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively. Learn More
  27. (2S,4S)-Sacubitril

    Catalog No. A20568
    Quick View
    (2S,4S)-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure. Learn More
  28. 2R,4R-Sacubitril

    Catalog No. A20564
    Quick View
    2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure. Learn More
  29. 2R,4S-Sacubitril

    Catalog No. A20559
    Quick View
    2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure. Learn More
  30. Sarmazenil

    Catalog No. A20487
    Quick View
    benzodiazepine receptor antagonist
    Sarmazenil is a benzodiazepine receptor antagonist. Learn More
  31. RMI 10874

    Catalog No. A20370
    Quick View
    RMI 10874 is a tilorone analogue. Tilorone is a small-molecule, orally bioavailable antiviral agent. RMI 10874 completely abolishes lung colonization of an H-2 negative (GR9.B9) MCA-induced fibrosarcoma clone. Learn More
  32. TMPyP4 tosylate

    Catalog No. A20124
    Quick View
    telomerase inhibitor
    TMPyP4 tosylate (TMP 1363) is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines. Learn More
  33. Saredutant

    Catalog No. A20096
    Quick View
    NK2 receptor antagonist
    Saredutant is a selective NK2 receptor antagonist. Learn More
  34. ACP-105

    Catalog No. A19778
    Quick View
    androgen receptor modulator
    ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively. Learn More
  35. Ensartinib

    Catalog No. A19720
    Quick View
    ALK/MET inhibitor
    Ensartinib (X-396) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. Learn More
  36. Moniliformin sodium salt

    Catalog No. A19635
    Quick View
    Moniliformin sodium salt is a potent, water-soluble mycotoxin isolate from Fusarium moniliforme. Learn More
  37. Pratosartan

    Catalog No. A19381
    Quick View
    angiotensin II receptor antagonist
    Pratosartan is a selective angiotensin II receptor antagonist. Learn More
  38. Teslexivir

    Catalog No. A19272
    Quick View
    Teslexivir (BTA074; AP 611074) is a topical antiviral agent that is a potent and selective inhibitor of the interaction between two essential viral proteins, E1 and E2, an interaction that is a necessary step for Human Papilloma Virus (HPV) 6 and 11 DNA replication and thus viral production. Learn More
  39. Dantrolene sodium

    Catalog No. A17644
    Quick View
    Calcium channel proteins inhibitor
    Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Dantrolene sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. Learn More
  40. JTV-519 free base

    Catalog No. A21846
    Quick View
    Ca2+-dependent blocker
    TV-519 free base (K201 free base) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties. Learn More
  41. Ensartinib hydrochloride

    Catalog No. A21719
    Quick View
    ALK/MET inhibitor
    Ensartinib hydrochloride (X-396 hydrochloride) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. Learn More
  42. (R)-UT-155

    Catalog No. A21677
    Quick View
    SARD ligand
    (R)-UT-155 (compound 11) is a selective androgen receptor degrader (SARD) ligand. Less active than the S-isomer. Learn More
  43. Azilsartan D5

    Catalog No. A21600
    Quick View
    angiotensin II type 1 receptor antagonist
    Azilsartan D5 is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist. Learn More
  44. Losartan (D4 Carboxylic Acid)

    Catalog No. A21578
    Quick View
    angiotensin II receptor antagonist
    Losartan D4 Carboxylic Acid is the deuterium labeled Losartan(EXP-3174), which is an angiotensin II receptor antagonist. Learn More
  45. RAD140

    Catalog No. A21205
    Quick View
    androgen receptor modulator
    RAD140 is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). Learn More
  46. Sarolaner

    Catalog No. A21115
    Quick View
    Sarolaner (PF-6450567) is an orally active, broad-spectrum ectoparasiticide, has efficacy against fleas and ticks on dogs, with LC80 of 0.3 μg/mL against C. felis and an LC100 of 0.003 μg/mL against O. turicata. Learn More
  47. Risarestat

    Catalog No. A21112
    Quick View
    aldose reductase inhibitor
    Risarestat (CT-112), an aldose reductase inhibitor, is developed for the treatment of diabetic complications Learn More
  48. Azilsartan medoxomil monopotassium

    Catalog No. A20860
    Quick View
    angiotensin II receptor type 1 antagonist
    Azilsartan medoxomil monopotassium is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. Learn More
  49. Olumacostat glasaretil

    Catalog No. A20840
    Quick View
    ACC inhibitor
    Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). Learn More

Items 1 to 50 of 163 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4

Set Ascending Direction
Rewards