Search results for 'trv130 hcl'

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  1. Lexibulin dihydrochloride

    Catalog No. A21774
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    tubulin polymerisation inhibitor
    Lexibulin 2Hcl (CYT-997 2Hcl) is a potent tubulin polymerisation inhibitor with IC50 of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Learn More
  2. MCOPPB triHydrochloride

    Catalog No. A21722
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    nociceptin receptor agonist
    MCOPPB 3Hcl is a nociceptin receptor agonist with pKi of 10.07; weaker activity at other opioid receptors. Learn More
  3. GW791343 trihydrochloride

    Catalog No. A21204
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    P2X7 allosteric modulator
    GW791343 3Hcl is a P2X7 allosteric modulator; exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2). Learn More
  4. HAX1 Antibody

    Catalog No. AP3109
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    HCLS1-associated protein X-1, Mouse Anti Human Learn More
  5. HAX1 Human

    Catalog No. AP0623
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    HCLS1 Associated Protein X-1 Human Recombinant Learn More
  6. Azacosterol

    Catalog No. A13295
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    24-DHCR inhibitor
    Azacosterol acts as an inhibitor of 24-dehydrocholesterol reductase (24-DHCR), preventing the formation of cholesterol from desmosterol. Learn More
  7. Cyclizine 2HCl

    Catalog No. A16472
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    Histamine H1 receptor antagonist
    Cyclizine 2HCl is a piperazine derivative with Histamine H1 receptor antagonist activity. Learn More
  8. Pyridoxamine 2HCl

    Catalog No. A16199
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    Pyridoxamine is one form of vitamin B6. Chemically it is based on a pyridine ring structure, with hydroxyl, methyl, aminomethyl, and hydroxymethyl substituents. Learn More
  9. Mibefradil dihydrochloride

    Catalog No. A12482
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    Calcium channel blocker
    Mibefradil 2Hcl is calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 uM and 18.6 uM for T-type and L-type channels respectively. Learn More
  10. K-7174 2HCl

    Catalog No. A15446
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    Cell adhesion inhibitor
    K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1beta or TNF-alpha. Learn More
  11. KX2-391 2HCl

    Catalog No. A11471
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    Src inhibitor
    KX2-391 2Hcl is the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Learn More
  12. AT7867 2HCl

    Catalog No. A15006
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    Akt inhibitor
    AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family. Learn More
  13. JP 1302 2HCl

    Catalog No. A13412
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    α2C antagonist
    JP 1302 2HCl is a potent and selective α2C antagonist. Learn More
  14. A 943931 2HCl

    Catalog No. A13442
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    Histamine H4 receptor antagonist
    A 943931 2HCl is a potent and selective histamine H4 receptor antagonist (pKi values are 7.15 and 8.12 at human and rat receptors respectively). Learn More
  15. CP 31398 2HCl

    Catalog No. A13522
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    p53 stabilizer
    CP 31398 2HCl has been shown to act as a stabilizing agent for p53, and to promotes activity of p53 in cancer cell lines. Learn More
  16. RN-1 2HCl

    Catalog No. A14344
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    MAO inhibitor
    RN-1 2HCl exhibits selectivity for LSD1 over monoamine oxidase (MAO)-A and MAO-B (IC50 values are 70 nM, 0.51 and 2.79 μM respectively, in a horseradish peroxidase-coupled assay). Learn More
  17. 5-Iodo-A-85380 2HCl

    Catalog No. A13639
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    nAChR agonist
    5-Iodo-A-85380 2HCl is a highly potent and subtype-selective agonist for the a4b2 and a6b2 nicotinic acetylcholine receptors. Learn More
  18. Glycyl-H 1152 2HCl

    Catalog No. A13659
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    ROCK inhibitor
    Glycyl-H 1152 2HCl is a selective and potent ROCK inhibitor (IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 uM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.) Learn More
  19. Dorsomorphin 2HCl

    Catalog No. A13720
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    BMP inhibitor
    Dorsomorphin, also known as BML-275, is a selective small molecule inhibitor of BMP signaling, which promotes cardiomyogenesis in embryonic stem cells. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling. Learn More
  20. Nitrarine 2HCl

    Catalog No. A13911
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    Nitrarine 2HCl is a hypotensive? spasmolytic? coronary dilator? sedative in experimental arrhythmias. in experimental arrhythmias in the cat? caused by calcium chloride? Aconitine and electric cardiac stimulation? Nitrarine dihydrochloride presents a hypotensive? spasmolytic? coronary dilating and sedative action. Its antiarrhythmic properties are due to its stabilizating effects on the membrane and its coronary dilating action. Nitrarine dihydrochloride is 3-4 times as potent as Novocainamide and Quinidine? and the duration of its effect is 2-5 times longer than that of these products. Learn More
  21. Puromycin 2HCl

    Catalog No. A14268
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    protein synthesis inhibitor
    Puromycin 2HCl is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor. Learn More
  22. TAS 103 2HCl

    Catalog No. A14141
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    topoisomerase I/II inhibitor
    TAS 103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models Learn More
  23. Talniflumate

    Catalog No. A13339
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    CaCC blocker
    Talniflumate is a calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Learn More
  24. Quinacrine 2HCl

    Catalog No. A13242
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    Quinacrine 2HCl is a histamine N-methyltransferase inhibitor Learn More
  25. Cetirizine Dihydrochloride

    Catalog No. A10195
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    Cetirizine is a second-generation antihistamine, a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. Learn More
  26. GBR-12935 2HCl

    Catalog No. A11937
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    DAT and SLC6A2 inhibitor
    GBR-12935 is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. Learn More
  27. H 89 2HCl

    Catalog No. A11935
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    PKA inhibitor
    H 89 dihydrochloride is a cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase. Learn More
  28. B-HT 920 2HCl

    Catalog No. A11341
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    D2 receptor agonist
    B-HT 920 is a dopamine agonist that has been proposed as an antiparkinsonian agent. It also has α1-adrenergic and α2-adrenergic agonist activity. Learn More
  29. BMS-790052 2HCl

    Catalog No. A11336
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    NS5A inhibitor
    BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection. Learn More
  30. Pramipexole dihydrochloride monohyrate

    Catalog No. A10747
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    Dopamine Receptor Agonist
    Pramipexole is a dopamine agonist of the non-ergoline class indicated for treating early-stage Parkinson's disease (PD) and restless legs syndrome (RLS). Learn More
  31. Plerixafor 8HCl (DB06809)

    Catalog No. A10913
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    CXCR4 antagonist
    Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation. Learn More
  32. Vanoxerine 2HCl (GBR-12909)

    Catalog No. A10725
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    dopamine re-uptake inhibitor
    Vanoxerine (GBR-12909) is a piperazine derivative which is a potent and selective DRI. Learn More
  33. Meclizine 2HCl

    Catalog No. A11700
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    Meclizine is a human pregnane X receptor (hPXR) agonist. It possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Its antiemetic and antivertigo effects are not fully understood, but its central anticholinergic properties are partially responsible. Learn More
  34. Dimebon 2HCl

    Catalog No. A10312
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    Neuroprotectant
    Dimebon dihydrochloride is a non-selective antihistamine that displays cognitive enhancing abilities. Learn More
  35. Naftopidil 2HCl

    Catalog No. A10619
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    5-HT1A and α1-adrenergic receptor antagonist
    Naftopidil 2HCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively. Learn More
  36. MCOPPB 3HCl

    Catalog No. A10561
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    NOP receptor agonist
    MCOPPB is a compound which acts as a potent and selective agonist for the nociceptin receptor, with a pKi of 10.07. Learn More
  37. LY335979 (Zosuquidar 3HCl)

    Catalog No. A10549
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    P-gp modulator
    LY335979 (Zosuquidar trihydrochloride) is a potent highly selective P-gp inhibitor. Learn More
  38. Y-27632 2HCl

    Catalog No. A11001
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    ROCK Inhibitor
    Y-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs). Learn More
  39. MK-2206 2HCl

    Catalog No. A10003
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    AKT Inhibitor
    MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. Learn More
  40. TP0427736 HCl

    Catalog No. A22382
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    ALK5 kinase activity inhibitor
    TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. Learn More
  41. AMG-073 HCl (Cinacalcet HCl)

    Catalog No. A10219
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    CaSR activator
    AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium. Learn More
  42. SB203186 HCl

    Catalog No. A22523
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    5-HT4 receptor antagonist
    SB203186 is potent 5-HT4 receptor antagonist. Learn More
  43. Anlotinib HCl

    Catalog No. A17076
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    RTK inhibitor
    Anlotinib, also known as AL3818, is a receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic and anti-angiogenic activities. CAS: 1058156-90-3 (free base) 1360460-82-7 (HCl) Learn More
  44. L-778123 HCl

    Catalog No. A15796
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    FPTase inhibitor
    L-778123 HCl is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination. Learn More
  45. Blasticidin S HCl

    Catalog No. A14212
    Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor. Learn More
  46. Fexofenadine HCl

    Catalog No. A11859
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    COX inhibitor/histamine H1 receptor agonist
    Fexofenadine HCl is an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist Learn More
  47. GW3965 HCl

    Catalog No. A11204
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    LXR-like receptors agonist
    GW3965 HCl is a selective and orally active liver X receptor (LXR) full agonist. Learn More
  48. ADL5859 HCl

    Catalog No. A11072
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    Opioid Receptor agonist
    ADL5859 HCl is a highly potent and selective δ opioid receptor agonist with Ki value to be 0.84 nM and ED50 value to be 20 nM. Learn More
  49. Flavopiridol HCl

    Catalog No. A11045
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    CDK inhibitor
    Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells. Learn More
  50. CFI-400437 HCl

    Catalog No. A22463
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    CFI-400437 is a potent and selective inhibitor of polo-like kinase 4 (PLK4). Learn More

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