Search results for 'ur 144'
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gp130 inhibitor
SC-144 is an orally active small-molecule gp130 inhibitor.
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HSP90 inhibitor
EC 144 is a potent inhibitor of the heat shock protein 90 and was found to be effective in tumor growth suppression.
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Prodigiosin (Prodigiosine) HCl is a potent proapoptotic agent, and inhibits Wnt/β-catenin pathway.
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Aurora Kinase A/B inhibitor
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Daurichromenic acid is a terpenophenol with a potent anti-HIV activity.
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benzodiazepine derivative drug
Remimazolam, also known as CNS-7056, is a benzodiazepine derivative drug, developed by PAION, in collaboration with Japanese licensee Ono Pharmaceutical as an alternative to the short-acting imidazobenzodiazepine midazolam, for use in induction of anaesthesia and conscious sedation for minor invasive procedures.
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selective C5aR antagonist
Avacopan (CCX168) is an orally administered and selective C5a receptor (C5aR) antagonist.
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beta-lactamase inhibitor drug candidate
Durlobactam, also known as ETX2514, is a beta-lactamase inhibitor drug candidate.
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neuraminidase (NA) inhibitor
Laninamivir octanoate (CS-8958), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity.
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SCAP inhibitor
Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM.
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Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.
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antianti-inflammatoryand antioxidative effects
Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 ?M and 22.8 ?M for CYP2A6; Gentiopicroside has antianti-inflammatoryand antioxidative effects.
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anti-psoriatic agent
Periplogenin is a naturally occurring furanocoumarin found in Angelica dahurica roots, with potent anti-psoriatic effects. Periplogenin induces adipocyte differentiation.
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natural alkaloid
Berlambine is a natural alkaloid isolated from many plants.
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fluorescent indicator
MQAE is a fluorescent indicator that is quenched via collision with chloride, and is more sensitive and selective than 36Cl and microelectrode-based methods for chloride measurement in cells.
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modulator of estrogen receptor ER-alpha36
SNG-1153 is a modulator of estrogen receptor ER-alpha36.
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membrane-permeant synthetic inhibitor
KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II, with Ki of 370 nM.
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inhibitor of amyloid-β fibril formation and aggregation
TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. TAE-1 inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
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marine xenobiotic metabolite
Imidacloprid-urea with a role as a marine xenobiotic metabolite, is the primary imidacloprid soil metabolite, whereas imidacloprid-olefin is the main plant-relevant metabolite and is more toxic to insects than imidacloprid.
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Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities
Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica. Triphala inhibits NF-κB activation. Triphala exerts antifungal action. Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities.
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Lignine (Lignin) is a complex organic polymer, which plays an important role in plant cell wall structure.
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Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor.
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local anesthetic additive
Hyaluronidase (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is a naturally occurring enzyme that depolymerizes hyaluronic acid by cleavage of glycosidic bonds and has been used as a local anesthetic additive.
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neuraminidase inhibitor
Neuraminidase-IN-1 is a neuraminidase inhibitor, with an IC50 of 0.21 μM. Neuraminidase-IN-1 has excellent activity against H1N1 influenza virus.
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Wnt/β-catenin signaling inhibitor
CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus.
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near-infrared (NIR) probe
CRANAD-2 is a curcumin-derivatized near-infrared (NIR) probe that meets all the requirements for a NIR contrast agent for the detection of Abeta plaques both in vitro and in vivo.
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neuronal nicotinic acetylcholine receptors agonist
4BP-TQS is an allosteric agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs).
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neuroprotective agent
B355252 is a neuroprotective agent potentiating nerve growth factor (NGF)-induced neurite outgrowth.
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rabbit platelet sPLA2 inhibitor
YM-26734 is a rabbit platelet sPLA2 inhibitor that has been used to ameliorate local inflammatory responses in TPA-induced mouse ear edema.
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HCN4 CLP ligand
BPU-11 is a HCN4 CLP ligand. It acts by modulating channel function and completely abolishing the cAMP-induced shift in V1/2.
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urinary metabolite
Creatine riboside is a urinary metabolite and is a diagnostic and prognostic biomarker of lung cancer.
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fluorogenic probe
MSBN is a highly selective fluorogenic probe for thiols, selectively imaging thiols in live cells and specifically label protein thiols with a turn-on signal to determine diverse reversible protein thiol modifications.
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nuclear orphan receptor Nur77/NR4A1 agonist
Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC50 of 0.278 nM.
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anti-infective agent
RGW 611, a morpholine derivative, is an impurity of Nimorazole, which is an anti-infective agent against anaerobic bacteria and protozoa.
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fungicide
Pyrimorph is a fungicide with high activity against the plant pathogen Phytophthora capsici.
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non-narcotic analgesic
Simetride, a non-narcotic analgesic, is an ingredient of Kyorin AP2 which is used to treat low back pain, symptomatic neuralgia, headache, menstrual pain and etc.
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A1 adenosine receptor agonist
Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury.
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ultra short-acting benzodiazepine
Remimazolam besylate is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures.
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DNA methyltransferase inhibitor
Zebularine (NSC309132; 4-Deoxyuridine) is a DNA methyltransferase inhibitor.
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mitochondria-targeted antioxidant
Demethyleneberberine is a natural mitochondria-targeted antioxidant.
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ATP-competitive CK2 inhibitor
Ellagic acid hydrate is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM.
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bitter taste receptor TAS2R1 agonist
Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α.
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regulator of skeletal muscle mass
Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B is also a regulator of skeletal muscle mass.
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precipitating agent
Tomatine is an glycoalkaloid that occurs in the extract of leaves of wild tomato plants. It has been found to inhibit the growth of various fungi and bacteria. It is used as a precipitating agent for steroids.
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anti-inflammatory agent
Acetosyringone is a phenolic natural product with analgesic, antipyretic and anti-inflammatory actions.
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CDK4/6 inhibitor
Ribociclib hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively,
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PTEN inhibitor
BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity.
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