CDK

Items 101-134 of 134

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Catalog No.
Product Name
Application
Product Information
Product Citation
  1. CDK9 degrader

    PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.
  2. CDK9 inhibitor

    CDK9-IN-8 is a highly effective and selective CDK9 inhibitor with an IC50 of 12 nM.
  3. CDK2-cyclin A inhibitor

    NU6140 is a selective CDK2-cyclin A inhibitor (IC50, 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs.
  4. CDK inhibitor

    Alsterpaullone (9-Nitropaullone;NSC 705701) is a potent CDK inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively.
  5. CDC7 inhibitor

    Simurosertib (TAK-931) is a selective cycle 7 (CDC7) kinase inhibitor, with an IC50<0.3 nM.
  6. CDK2 inhibitor

    BGG463 (K03859) is an orally active type II CDK2 inhibitor.
  7. CDK2/9 inhibitor

    CYC065 is a second-generation, orally available ATP-competitive inhibitor of CDK2/CDK9 kinases with IC50s of 5 and 26 nM, respectively.
  8. CDK inhibitor

    THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM.
  9. CDK8 inhibitor

    CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor with an IC50 of 2.3 nM.
  10. ATP-competitive CDK2 inhibitor

    NU6300 is the first covalent ATP-competitive CDK2 inhibitor.
  11. CDK8 inhibitor

    Senexin A is a CDK8 inhibitor with an IC50 of 280 nM.
  12. Cdc7 inhibitor

    XL413 is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC50 of 3.4 nM, and also shows potent effect with IC50s of 215, 42 nM on CK2, PIM1, respectively, and an EC50 of 118 nM on pMCM.
  13. CDK inhibitor

    Voruciclib hydrochloride is a clinical stage orally active and selective CDK inhibitor with Ki values of 0.626 nM-9.1 nM.
  14. dual Cdc7/Cdk9 inhibitor

    PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively.
  15. CDK9 inhibitor

    CDKI-73 is a potent CDK9 inhibitor with Ki of 4 nM; shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).
  16. CDK8 inhibitor

    SEL120-34A HCl is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.
  17. CDK9 inhibitor

    CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection, with an IC50 of 39 nM for CDK9/CycT1, extracted from reference, compound 87.
  18. PTEF/CDK9 inhibitor

    (±)-BAY-1251152 is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor.
  19. PTEF/CDK9 inhibitor

    (-)-BAY-1251152 is an enanthiomer of BAY-1251152 with rotation (-). BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor.
  20. CDK4/CDK6 inhibitor

    Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively.
  21. CDK7 inhibitor

    LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.
  22. CDK7 inhibitor

    BS-181 hydrochloride is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.
  23. PKC inhibitor

    Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective protein kinase C (PKC) inhibitor.
  24. CDK7 inhibitor

    THZ2 is a potent and selective CDK7 inhibitor with an IC50 of 13.9 nM.
  25. CDK4/6 inhibitor

    Trilaciclib hydrochloride is a CDK4/6 inhibitor with IC50s of 1 nM and 4 nM for CDK4 and CDK6, respectively.
  26. CDK inhibitor

    GW779439X is an inhibitor of cyclin dependent kinase.
  27. CDK9 inhibitor

    JSH-150 is a highly selective and potent CDK9 inhibitor with an IC50 of 1 nM.
  28. ATP-competitive CDK2 and CDK5 inhibitor

    PNU112455A hydrochloride is an ATP-competitive CDK2 and CDK5 inhibitor.
  29. CDK4/6 inhibitor

    Ribociclib hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively,
  30. CDK8/CDK19 inhibitor

    BRD6989 is a selective inhibitor of CDK8 and CDK19. BRD6989 upregulates IL-10. BRD6989 is an analog of the natural product cortistatin A (dCA).
  31. CDK6 degrader

    BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader (PROTAC).
  32. dual inhibitor of CDK12/CDK13

    SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM).
  33. CDK8 and CDK19 inhibitor

    AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively.
  34. dual inhibitor of protein kinase and CDK

    6-(Dimethylamino)purine is a dual inhibitor of protein kinase and CDK.

Items 101-134 of 134

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