Cilomilast (SB-207499)

Catalog No.: A10216

PDE-4 inhibitor

Cilomilast (SB-207499)

Cilomilast (SB-207499) Chemical Structure

CAS NO. 153259-65-5

Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD.

Availability: In stock

Package Price Qty
5 mg
$75.00
10 mg
$138.00
50 mg
$420.00
100 mg
$680.00
10mM * 1mL in DMSO
$111.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD.
Targets
In vitro (25°C) DMSO 69 mg/mL (200.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol 50 mg/mL (145.59 mM)
In vivo 5% DMSO/95% Corn oil 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.12 mL 145.6 mL 291.21 mL
0.5 mM 5.82 mL 29.12 mL 58.24 mL
1 mM 2.91 mL 14.56 mL 29.12 mL
5 mM 0.58 mL 2.91 mL 5.82 mL

*The above data is based on the productmolecular weight 343.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10216
Actions Inhibitor
M. Wt 343.4
Formula C20H25NO4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 153259-65-5
Synonyms SB207499, Ariflo, SB-207,499
SMILES COC1=C(C=C(C=C1)C2(CCC(CC2)C(=O)O)C#N)OC3CCCC3

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