Cobicistat (GS-9350)

Catalog No.: A11277

CYP3A Inhibitor

Cobicistat (GS-9350)

Cobicistat (GS-9350) Chemical Structure

CAS NO. 1004316-88-4

Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.

Availability: In stock

Package Price Qty
2 mg
$100.00
5 mg
$80.00
10 mg
$135.00
25 mg
$250.00
10mM * 1mL in DMSO
$120.00
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Biological Activity

Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.
Targets
CYP3A
30 nM-285 nM
In vitro (25°C) DMSO 85 mg/mL (109.53 mM)
Water Insoluble
Ethanol 85 mg/mL (109.53 mM)
In vivo 5% DMSO+40% PEG 300+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.05 mL 65.27 mL 130.55 mL
0.5 mM 2.61 mL 13.05 mL 26.11 mL
1 mM 1.31 mL 6.53 mL 13.05 mL
5 mM 0.26 mL 1.31 mL 2.61 mL

*The above data is based on the productmolecular weight 766.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11277
Actions Inhibitor
CAS No. 1004316-88-4
Formula C40H53N7O5S2
M. Wt 766.0
Purity >99%
Synonyms GS9350
SMILES CC(C)C1=NC(=CS1)CN(C)C(=O)N[[email protected]@H](CCN2CCOCC2)C(=O)N[[email protected]](CC[[email protected]](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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