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$0.00 Biological Activity
CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2.
Targets
| Target | Value |
|---|---|
| EGFR | IC50: 2.4nM |
| HDAC | IC50: 4.4nM |
| HDAC1 | IC50: 4.5nM |
| HDAC6 | IC50: 5.1nM |
| HDAC3 | IC50: 9.1nM |
| HDAC5 | IC50: 11.4nM |
| HDAC2 | IC50: 12.6nM |
| HDAC4 | IC50: 13.2nM |
| HER2 | IC50: 15.7nM |
| HDAC10 | IC50: 26.1nM |
| HDAC9 | IC50: 67.2nM |
| HDAC8 | IC50: 79.8nM |
| HDAC7 | IC50: 373nM |
| In vitro (25°C) | DMSO | 20 mg/mL (46.03 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 15% Captisol | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.01 mL | 115.07 mL | 230.15 mL |
| 0.5 mM | 4.6 mL | 23.01 mL | 46.03 mL |
| 1 mM | 2.3 mL | 11.51 mL | 23.01 mL |
| 5 mM | 0.46 mL | 2.3 mL | 4.6 mL |
*The above data is based on the productmolecular weight 434.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10246 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 434.5 |
| Formula | C24H26N4O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1012054-59-9 |
| Synonyms | CUDC101 |
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO |
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