Catalog No.: A10249

Hedgehog signaling inhibitor


Cyclopamine Chemical Structure

CAS NO. 4449-51-8

Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.

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Biological Activity

Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.
Smoothened (TM3Hh12 cells)
46 nM
In vitro DMSO Insoluble
Water DMF Warmed: 9 mg/mL (21.86 mM)
Ethanol Warmed: 2 mg/mL (4.85 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.3 mL 121.48 mL 242.95 mL
0.5 mM 4.86 mL 24.3 mL 48.59 mL
1 mM 2.43 mL 12.15 mL 24.3 mL
5 mM 0.49 mL 2.43 mL 4.86 mL

*The above data is based on the productmolecular weight 411.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10249
Actions Inhibitor
CAS No. 4449-51-8
Formula C27H41NO2
M. Wt 411.6
Purity >98%
Synonyms 11-deoxojervine
SMILES C[[email protected]]1C[[email protected]@H]2[[email protected]]([[email protected]]([[email protected]]3(O2)CC[[email protected]]4[[email protected]@H]5CC=C6C[[email protected]](CC[[email protected]@]6([[email protected]]5CC4=C3C)C)O)C)NC1

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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