Biological Activity
CYT997 is a novel anti-cancer vascular disrupting agent (VDA). In vitro, CYT997 is shown to potently inhibit the proliferation of vascular endothelial growth factor-stimulated human umbilical vein endothelial cells (IC(50) 3.7 ± 1.8 nM) and cause significant morphological changes at 100 nM, including membrane blebbing.
Targets
Microtubules (cancer cell lines) | ||||
10 nM-100 nM |
In vitro | DMSO | 86 mg/mL (197.91 mM) | |
Water | <1 mg/mL (<1 mM) | ||
Ethanol | 20 mg/mL (46.02 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.01 mL | 115.07 mL | 230.15 mL |
0.5 mM | 4.6 mL | 23.01 mL | 46.03 mL |
1 mM | 2.3 mL | 11.51 mL | 23.01 mL |
5 mM | 0.46 mL | 2.3 mL | 4.6 mL |
*The above data is based on the productmolecular weight 434.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10264 |
---|---|
Actions | Inhibitor |
M. Wt | 434.5 |
Formula | C24H30N6O2 |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 917111-44-5 |
Synonyms | CYT-997, Lexibulin |
SMILES | CCC[[email protected]@H](C1=CN=CC=C1)NC2=NC(=NC=C2C)C3=CC(=C(C=C3)NC(=O)NCC)OC |
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