Sorafenib (Nexavar)Catalog No. A10001

Quick Overview

Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
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Sorafenib (Nexavar)

Sorafenib (Nexavar)  Citations(6)
  • Fangyuan Lai,et al. Platelet-rich plasma enhances the proliferation of human adipose stem cells through multiple signaling pathways, Stem Cell Res Ther, 2018, 9: 107 29661222
  • Brittany M. Duggan,et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 28484277
  • Cong Li,et al. AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia., Mol Cancer Ther., 2015, Feb;14(2):375-83. 25487917
  • Zhihong Li,et al. Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3., J Med Chem., 2014, Apr 24;57(8):3430-49. 24641103
  • Hideki Yamaguchi,et al. Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and fibroblast growth factor receptor inhibitors, Cancer Sci, 2014, 105(5): 528-536 24612061
  • Yaping Zhang,et al. FLT3 and CDK4/6 inhibitors: Signaling mechanisms and tumor burden in subcutaneous and orthotopic mouse models of acute myeloid leukemia, J Pharmacokinet Pharmacodyn., 2014, 41(6): 675-691. 25326874
  • Product Information
    Catalog Num A10001
    M. Wt 637
    Formula C21H16ClF3N4O3.C7H8O3S
    Solubility DMSO>127mg/mL Water <1mg/mL Ethanol <1mg/mL
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 475207-59-1
    Synonyms Bay 43-9006
    Chemical Name 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
    SMILES Code CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

    Biological activity
    Introduction
    Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
    Targets
    Target Value
    Raf-1IC50: 6nM
    VEGFR2/Flk1IC50: 15nM
    B-RafIC50: 22nM
    B-Raf(V599E)IC50: 38nM
    PDGFRβIC50: 57nM
    mPDGFRβIC50: 57nM
    FLT3IC50: 58nM
    c-KitIC50: 68nM
    VEGFR2IC50: 90nM
    FGFR1IC50: 580nM
    ERK1IC50: >10μM
    MEK1IC50: >10μM
    EGFRIC50: >10μM
    HER2IC50: >10μM
    IGF-1RIC50: >10μM
    c-MetIC50: >10μM
    PKBIC50: >10μM
    PKAIC50: >10μM
    CDK1/CyclinBIC50: >10μM
    PKCαIC50: >10μM
    PKCγIC50: >10μM
    Pim1IC50: >10μM
    Solubility
    Solubility (25C)* In vitro DMSO 63 mg/mL heating (135.53 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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