MLN8237 (Alisertib)Catalog No. A10004
Quick Overview
MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3..
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Product Information
Catalog Num | A10004 |
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M. Wt | 518.9 |
Formula | C27H20ClFN4O4 |
Solubility | DMSO>44mg/mL Water <1mg/mL Ethanol <1mg/mL |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1028486-01-2 |
Synonyms | N/A |
Chemical Name | 4-[[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid |
SMILES Code | COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC |
Biological activity
Introduction |
MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3.. |
Solubility
Solubility (25C) * | In vitro | DMSO | 27 mg/mL (52.03 mM) |
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Water | <1 mg/mL (<1 mM) | ||
Ethanol | <1 mg/mL (<1 mM) | ||
In vivo | 15% Captisol | 30 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Return Policy | Contact information |
Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems. >>This offer is only valid for products purchased directly from Adooq and its authorized distributors. >>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased. |
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