AP24534 (Ponatinib)

Catalog No. A10080

AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor.
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Catalog Num A10080
M. Wt 532.6
Formula C29H27F3N6O
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 943319-70-8
Synonyms Ponatinib
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor.
Targets
Target Value
AblIC50: 0.37nM
PDGFRαIC50: 1.1nM
VEGFR2IC50: 1.5nM
FGFR1IC50: 2.2nM
c-SrcIC50: 5.4nM
c-KitIC50: 12.5nM
Insulin ReceptorIC50: >1μM
IGF-1RIC50: >1μM
AuroraAIC50: >1μM
CDK2/CyclinEIC50: >1μM
In vitro (25°C) DMSO 30 mg/mL (56.33 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.78 mL 93.88 mL 187.76 mL
0.5 mM 3.76 mL 18.78 mL 37.55 mL
1 mM 1.88 mL 9.39 mL 18.78 mL
5 mM 0.38 mL 1.88 mL 3.76 mL

*The above data is based on the productmolecular weight 532.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.