AP24534 (Ponatinib)Catalog No. A10080

Quick Overview

AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor.
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AP24534 (Ponatinib)

AP24534 (Ponatinib)  Citations(5)
  • Yamamoto Y, .et al. Development of a sandwich enzyme-linked immunosorbent assay for the quantification of ponatinib in serum, Anal Biochem, 2019, Feb 13. pii: S0003-2697(18)31083-2 PMID: 30771339
  • N Naganna, .et al. Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice, EBioMedicine, 2019, Jan 24. pii: S2352-3964(19)30012-X PMID: 30686755
  • Takuya Hirao, .et al. Altered intracellular signaling by imatinib increases the anti-cancer effects of tyrosine kinase inhibitors in chronic myelogenous leukemia cells, Cancer Sci, 2018, Jan; 109(1): 121-131 PMID: 29121435
  • Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Product Information
    Catalog Num A10080
    M. Wt 532.6
    Formula C29H27F3N6O
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 943319-70-8
    Synonyms Ponatinib
    SMILES Code CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

    Biological activity
    Introduction
    AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor.
    Targets
    Target Value
    AblIC50: 0.37nM
    PDGFRαIC50: 1.1nM
    VEGFR2IC50: 1.5nM
    FGFR1IC50: 2.2nM
    c-SrcIC50: 5.4nM
    c-KitIC50: 12.5nM
    Insulin ReceptorIC50: >1μM
    IGF-1RIC50: >1μM
    AuroraAIC50: >1μM
    CDK2/CyclinEIC50: >1μM
    Solubility
    Solubility (25C) * In vitro DMSO 30 mg/mL (56.33 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 10 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
    Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems.

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    >>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


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