Aprepitant (MK-0869)

Catalog No. A10083

Aprepitant is classified as an NK1 antagonist. Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons. It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy.

Product Citations

Kodji X, .et al. Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis, FASEB J, 2018, Sep 11:fj201800395RR PMID: 30204499

Technical details

Catalog Num	A10083
M. Wt	534.4
Formula	C23H21F7N4O3
Purity	>98%
Storage	at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.	170729-80-3
Synonyms	MK0869, MK-869, L-754030, Emend
SMILES	C[[email protected]](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[[email protected]@H]2[[email protected]@H](N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F

Biological Activity

Targets

Neurokinin-1 receptor (Cell-free assay)
0.1 nM

Solubility *

In vitro (25°C)	DMSO	96 mg/mL (179.63 mM)
	Water	Insoluble
	Ethanol	14 mg/mL (26.19 mM)
In vivo	5% DMSO+corn oil	12 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.71 mL	93.56 mL	187.13 mL
0.5 mM	3.74 mL	18.71 mL	37.43 mL
1 mM	1.87 mL	9.36 mL	18.71 mL
5 mM	0.37 mL	1.87 mL	3.74 mL

*The above data is based on the productmolecular weight 534.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience