BEZ235 (NVP-BEZ235, Dactolisib)

Catalog No. A10133

BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.
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Catalog Num A10133
M. Wt 469.6
Formula C30H23N5O
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 915019-65-7
Synonyms
SMILES CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5
BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.
Targets
Target Value
p110αIC50: 4nM
p110γIC50: 5nM
mTOR(p70S6K)IC50: 6nM
p110δIC50: 7nM
ATRIC50: 21nM
p110βIC50: 75nM
EGFR/ErbB1IC50: >8.5μM
VEGFR1/FLT1IC50: >10μM
FLT3IC50: >10μM
IGF-1RIC50: >10μM
EphB4IC50: >10μM
RETIC50: >10μM
Tie-2IC50: >10μM
c-MetIC50: >10μM
FGFR(K650E)IC50: >10μM
FAKIC50: >10μM
JAK2IC50: >10μM
c-AblIC50: >10μM
c-SrcIC50: >10μM
PKAIC50: >10μM
Akt1/PKBαIC50: >10μM
PDK-1IC50: >10μM
B-Raf(V599E)IC50: >10μM
CDK1IC50: >10μM
In vitro (25°C) DMSO 0.01 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo NMP/polyethylene glycol 300 (10/90, v/v) 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.29 mL 106.47 mL 212.95 mL
0.5 mM 4.26 mL 21.29 mL 42.59 mL
1 mM 2.13 mL 10.65 mL 21.29 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.