BI6727 (Volasertib)Catalog No. A10135

Quick Overview

BI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines).
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BI6727 (Volasertib)

BI6727 (Volasertib)  Citations(1)
  • Xiaofei Xin, .et al. ROS responsive polymeric micelles for triggered simultaneous delivery of PLK1 inhibitor/miR-34a and effective synergistic therapy in pancreatic cancer, ACS Appl Mater Interfaces, 2019, 2019
  • Product Information
    Catalog Num A10135
    M. Wt 618.8
    Formula C34H50N8O3
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 755038-65-4
    Synonyms Volasertib, BI-6727
    SMILES Code CC[[email protected]@H]1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C

    Biological activity
    Introduction
    BI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines).
    Targets
    PLK1 (Cell-free assay)
    0.87 nM
    Solubility
    Solubility (25C) * In vitro DMSO 50 mg/mL (80.8 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol 124 mg/mL (200.38 mM)
    In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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    >>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


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    High Purity Kinase Inhibitors on Signaling Pathways

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