BI6727 (Volasertib)

Catalog No. A10135

BI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines).
  • Xiaofei Xin, .et al. ROS responsive polymeric micelles for triggered simultaneous delivery of PLK1 inhibitor/miR-34a and effective synergistic therapy in pancreatic cancer, ACS Appl Mater Interfaces, 2019, 2019
Catalog Num A10135
M. Wt 618.8
Formula C34H50N8O3
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 755038-65-4
Synonyms Volasertib, BI-6727
SMILES CC[[email protected]@H]1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C
BI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines).
Targets
PLK1 (Cell-free assay)
0.87 nM
In vitro (25°C) DMSO 50 mg/mL (80.8 mM)
Water <1 mg/mL (<1 mM)
Ethanol 124 mg/mL (200.38 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.16 mL 80.8 mL 161.6 mL
0.5 mM 3.23 mL 16.16 mL 32.32 mL
1 mM 1.62 mL 8.08 mL 16.16 mL
5 mM 0.32 mL 1.62 mL 3.23 mL

*The above data is based on the productmolecular weight 618.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.