BIIB021

Catalog No. A10143

BIIB021 is an oral fully synthetic Hsp90 inhibitor that selectively and potently inhibits the molecular chaperone Hsp90 thereby inhibiting the proper assembly of multiple oncogenic proteins involved in tumor growth and survival.
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
Catalog Num A10143
M. Wt 318.8
Formula C14H15ClN6O
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 848695-25-0
Synonyms CNF2024
SMILES CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N
BIIB021 is an oral fully synthetic Hsp90 inhibitor that selectively and potently inhibits the molecular chaperone Hsp90 thereby inhibiting the proper assembly of multiple oncogenic proteins involved in tumor growth and survival.
Targets
HSP90 HSP90
1.7 nM(Ki)38 nM(EC50)
In vitro (25°C) DMSO 64 mg/mL (200.77 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (6.27 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.37 mL 156.84 mL 313.68 mL
0.5 mM 6.27 mL 31.37 mL 62.74 mL
1 mM 3.14 mL 15.68 mL 31.37 mL
5 mM 0.63 mL 3.14 mL 6.27 mL

*The above data is based on the productmolecular weight 318.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.