Doramapimod (BIRB-796)

Catalog No. A10148

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
  • Perera LMB, .et al. The regulation of skin fibrosis in systemic sclerosis by extracellular ATP via P2Y2 purinergic receptor, J Invest Dermatol, 2018, Nov 4. pii: S0022-202X(18)32791-X PMID: 30404019
Catalog Num A10148
M. Wt 527.7
Formula C31H37N5O3
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 285983-48-4
Synonyms BIRB-796,BIRB 796
SMILES CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5
Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
Targets
p38α (Cell-free assay) p38α
0.1 nM(Kd)38 nM
In vitro (25°C) DMSO 106 mg/mL (200.88 mM)
Water <1 mg/mL (<1 mM)
Ethanol 106 mg/mL (200.88 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.95 mL 94.75 mL 189.5 mL
0.5 mM 3.79 mL 18.95 mL 37.9 mL
1 mM 1.9 mL 9.48 mL 18.95 mL
5 mM 0.38 mL 1.9 mL 3.79 mL

*The above data is based on the productmolecular weight 527.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.