Doramapimod (BIRB-796)Catalog No. A10148

Quick Overview

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
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Doramapimod (BIRB-796)

Doramapimod (BIRB-796)  Citations(1)
  • Perera LMB, .et al. The regulation of skin fibrosis in systemic sclerosis by extracellular ATP via P2Y2 purinergic receptor, J Invest Dermatol, 2018, Nov 4. pii: S0022-202X(18)32791-X PMID: 30404019
  • Product Information
    Catalog Num A10148
    M. Wt 527.7
    Formula C31H37N5O3
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 285983-48-4
    Synonyms BIRB-796,BIRB 796
    SMILES Code CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5

    Biological activity
    Introduction
    Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
    Targets
    p38α (Cell-free assay) p38α
    0.1 nM(Kd)38 nM
    Solubility
    Solubility (25C) * In vitro DMSO 106 mg/mL (200.88 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol 106 mg/mL (200.88 mM)
    In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
    Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems.

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    >>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


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    High Purity Kinase Inhibitors on Signaling Pathways

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