BIX 02189 Catalog No. A10151

Quick Overview

BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
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BIX 02189

BIX 02189   Citations(1)
  • Mitsunori Miyazaki,et al. TSC2/Rheb signaling mediates ERK坼dependent regulation of mTORC1 activity in C2C12 myoblasts, FEBS Open Bio, 2017, Mar; 7(3): 424-433 28286738
  • Product Information
    Catalog Num A10151
    M. Wt 440.5
    Formula C27H28N4O2
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 1094614-85-3
    Synonyms BIX02189, BIX-02189
    Chemical Name 3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide
    SMILES Code CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4

    Biological activity
    Introduction
    BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
    Targets
    Target Value
    MEK5IC50: 1.5nM
    ERK5IC50: 59nM
    TGFβR1IC50: 580nM
    MEK1IC50: >6.2μM
    MEK2IC50: >6.2μM
    ERK1IC50: >6.2μM
    JNK2IC50: >6.2μM
    EGFRIC50: >6.3μM
    STK16IC50: >6.3μM
    Solubility
    Solubility (25C) * In vitro DMSO 60 mg/mL heating (136.19 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol 80 mg/mL (181.59 mM)
    In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
    Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems.

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    >>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


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    High Purity Kinase Inhibitors on Signaling Pathways

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