Bortezomib (Velcade)

Catalog No. A10160

Bortezomib is a highly selective, reversible inhibitor of the 26S proteasome
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Catalog Num A10160
M. Wt 384.2
Formula C19H25BN4O4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 179324-69-7
Synonyms MG-341, PS-341
SMILES B([[email protected]](CC(C)C)NC(=O)[[email protected]](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
Bortezomib is a highly selective, reversible inhibitor of the 26S proteasome
20S proteasome (Cell-free assay)
0.6 nM(Ki)
In vitro (25°C) DMSO 77 mg/mL (200.39 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.03 mL 130.14 mL 260.28 mL
0.5 mM 5.21 mL 26.03 mL 52.06 mL
1 mM 2.6 mL 13.01 mL 26.03 mL
5 mM 0.52 mL 2.6 mL 5.21 mL

*The above data is based on the productmolecular weight 384.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.