Celastrol

Catalog No. A10192

Celastrol is a triterpenoid antioxidant compound isolated from the Chinese Thunder of God vine (T. wilfordii). In an isolated rat liver assay of lipid peroxidation, celastrol had an IC50 value of 7 µM, equivalent to about 15 times the antioxidant potency of α-tocopherol.

  • R. San Gil, .et al. Neurodegenerative disease-associated protein aggregates are poor inducers 2 of the heat shock response in neuronal-like cells, bioRxiv, 2020, Jan
  • Abdin AA, .et al. Modulatory effect of celastrol on Th1/Th2 cytokines profile, TLR2 and CD3+ T-lymphocyte expression in a relapsing-remitting model of multiple sclerosis in rats., Eur J Pharmacol., 2014, 742:102-12 PMID: 25218987
Catalog Num A10192
M. Wt 450.6
Formula C29H38O4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 34157-83-0
Synonyms
SMILES CC1=C(C(=O)C=C2C1=CC=C3[[email protected]]2(CC[[email protected]@]4([[email protected]@]3(CC[[email protected]@]5([[email protected]]4C[[email protected]](CC5)(C)C(=O)O)C)C)C)C)O

Celastrol is a triterpenoid antioxidant compound isolated from the Chinese Thunder of God vine (T. wilfordii). In an isolated rat liver assay of lipid peroxidation, celastrol had an IC50 value of 7 µM, equivalent to about 15 times the antioxidant potency of α-tocopherol.

Targets
20S proteasome 20S proteasome
N/A2.5 μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.19 mL 110.96 mL 221.93 mL
0.5 mM 4.44 mL 22.19 mL 44.39 mL
1 mM 2.22 mL 11.1 mL 22.19 mL
5 mM 0.44 mL 2.22 mL 4.44 mL

*The above data is based on the productmolecular weight 450.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.