CisplatinCatalog No. A10221

Quick Overview

Cisplatin was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).
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Cisplatin

Cisplatin  Citations(3)
  • Amnah Alshangiti, .et al. The dietary flavonoid isoliquiritigenin is a potent cytotoxin for human neuroblastoma cells, Neuronal Signal, 2019, 2019
  • Calhelha RC, .et al. Mathematical models of cytotoxic effects in endpoint tumor cell line assays: critical assessment of the application of a single parametric value as a standard criterion to quantify the dose-response effects and new unexplored proposal formats, Analyst, 2017, Oct 23;142(21):4124-4141 PMID: 28991301
  • Pi-Lin Sung, .et al. Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma, Oncotarget, 2016, Jan 26; 7(4): 4036-4047 PMID: 26716408
  • Product Information
    Catalog Num A10221
    M. Wt 300.1
    Formula Cl2H4N2Pt
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 15663-27-1
    Synonyms cisplatinum, CDDP, cis-diamminedichloroplatinum(II)
    SMILES Code N.N.Cl[Pt+2]Cl

    Biological activity
    Introduction
    Cisplatin was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).
    Targets
    DNA synthesis (Tumor cells)
    Solubility
    Solubility (25C)* In vitro DMSO 60 mg/mL (199.96 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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