GDC-0449 (Vismodegib)

Catalog No. A10258

GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
  • Yi Yang, .et al. Tumidulin, a Lichen Secondary Metabolite, Decreases the Stemness Potential of Colorectal Cancer Cells, Molecules, 2018, Nov; 23(11): 2968 PMID: 30441806
  • Olesen UH, .et al. Topical delivery of vismodegib using ablative fractional laser and micro-emulsion formulation in vitro, Lasers Surg Med, 2018, Aug 28 PMID: 30152536
Warning WARNING: Attention California Residents: This product can expose you to chemicals including GDC-0449 (Vismodegib) , which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov
Catalog Num A10258
M. Wt 421.3
Formula C19H14Cl2N2O3S
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 879085-55-9
Synonyms
SMILES ClC1=C(C=C(NC(C2=CC=C(S(C)(=O)=O)C=C2Cl)=O)C=C1)C3=NC=CC=C3
GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
In vitro (25°C) DMSO 84 mg/mL (199.38 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.74 mL 118.68 mL 237.36 mL
0.5 mM 4.75 mL 23.74 mL 47.47 mL
1 mM 2.37 mL 11.87 mL 23.74 mL
5 mM 0.47 mL 2.37 mL 4.75 mL

*The above data is based on the productmolecular weight 421.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.