E7080 (Lenvatinib)Catalog No. A10340

Quick Overview

E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.
Products are for laboratory research use only. Not for human use. We do not sell to patients.

E7080 (Lenvatinib)

E7080 (Lenvatinib)  Citations(3)
  • Koide H,et al. Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1, Xenobiotica, 2018, Oct;48(10):1059-1071 29034773
  • Fujita KI,et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 28479358
  • Tomoko Ogawa-Morita,et al. Validation of a Liquid Chromatography-Tandem Mass Spectrometric Assay for Quantitative Analysis of Lenvatinib in Human Plasma, Int J Anal Chem, 2017, 2017: 2341876 28680445
  • Product Information
    Catalog Num A10340
    M. Wt 426.9
    Formula C21H19ClN4O4
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 417716-92-8
    Synonyms E-7080
    Chemical Name 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxy-quinoline-6-carboxamid
    SMILES Code COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl

    Biological activity
    Introduction
    E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.
    Targets
    Target Value
    VEGFR2/KDRIC50: 4.0nM
    VEGFR3/FLT4IC50: 5.2nM
    VEGFR1/FLT1IC50: 22nM
    PDGFRβIC50: 39nM
    FGFR1IC50: 46nM
    PDGFRαIC50: 51nM
    KitIC50: 100nM
    EphB4IC50: >10μM
    IGF-1RIC50: >10μM
    Insulin ReceptorIC50: >10μM
    SrcIC50: >10μM
    Akt1IC50: >10μM
    CDK4/CyclinDIC50: >10μM
    PLK1IC50: >10μM
    FAKIC50: >10μM
    PKCαIC50: >10μM
    Solubility
    Solubility (25C) * In vitro DMSO 40 mg/mL (93.7 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 0.5% methylcellulose 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
    Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems.

    >>This offer is only valid for products purchased directly from Adooq and its authorized distributors.

    >>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


    Website: www.adooq.com
    Order: [email protected]
    Phone:
    (866)930-6790 (US & Canada)
    +1-323-389-9269 (Outside of US & CAN)
    Fax:
    (866)333-9607 (US & Canada)
    +1-323-606-8156 (Outside of US & CAN)
    Support:
    [email protected]

    High Purity Kinase Inhibitors on Signaling Pathways

    Copyright© 2006-2017 Adooq BioScience LLC, All Rights Reserved.
    4000 Barranca Parkway, Suite 250, Irvine, CA 92604 USA. Tel: 855-930-6790