E7080 (Lenvatinib)Catalog No. A10340

Quick Overview

E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.
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E7080 (Lenvatinib)

E7080 (Lenvatinib)  Citations(3)
  • Koide H,et al. Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1, Xenobiotica, 2018, Oct;48(10):1059-1071 29034773
  • Fujita KI,et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 28479358
  • Tomoko Ogawa-Morita,et al. Validation of a Liquid Chromatography-Tandem Mass Spectrometric Assay for Quantitative Analysis of Lenvatinib in Human Plasma, Int J Anal Chem, 2017, 2017: 2341876 28680445
  • Product Information
    Catalog Num A10340
    M. Wt 426.9
    Formula C21H19ClN4O4
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 417716-92-8
    Synonyms E-7080
    Chemical Name 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxy-quinoline-6-carboxamid
    SMILES Code COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl

    Biological activity
    E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.
    Target Value
    VEGFR2/KDRIC50: 4.0nM
    VEGFR3/FLT4IC50: 5.2nM
    VEGFR1/FLT1IC50: 22nM
    PDGFRβIC50: 39nM
    FGFR1IC50: 46nM
    PDGFRαIC50: 51nM
    KitIC50: 100nM
    EphB4IC50: >10μM
    IGF-1RIC50: >10μM
    Insulin ReceptorIC50: >10μM
    SrcIC50: >10μM
    Akt1IC50: >10μM
    CDK4/CyclinDIC50: >10μM
    PLK1IC50: >10μM
    FAKIC50: >10μM
    PKCαIC50: >10μM
    Solubility (25C) * In vitro DMSO 40 mg/mL (93.7 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 0.5% methylcellulose 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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