Fasudil HCl (HA-1077)Catalog No. A10381

Quick Overview

Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).
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Fasudil HCl (HA-1077)

Fasudil HCl (HA-1077)  Citations(3)
  • Kumar M, .et al. Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NF??B, Behav Brain Res, 2018, Oct 1;351:4-16 PMID: 29807069
  • Wei J, .et al. Inhibition of RHO Kinase by Fasudil Attenuates Ischemic Lung Injury After Cardiac Arrest in Rats, Shock, 2018, Dec;50(6):706-713 PMID: 29283979
  • Hofni A, .et al. Fasudil ameliorates endothelial dysfunction in streptozotocin-induced diabetic rats: a possible role of Rho kinase, Naunyn Schmiedebergs Arch Pharmacol, 2017, Aug;390(8):801-811 PMID: 28493050
  • Product Information
    Catalog Num A10381
    M. Wt 327.8
    Formula C14H17N3O2S.HCl
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 105628-07-7
    Synonyms AT-877
    SMILES Code C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl

    Biological activity
    Introduction
    Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).
    Targets
    ROCK2 (Cell-free assay) PKA (Cell-free assay) PKG (Cell-free assay) PKC (Cell-free assay) MLCK (Cell-free assay)
    330 nM(Ki)1.6 μM(Ki)1.6 μM(Ki)3.3 μM(Ki)36 μM(Ki)
    Solubility
    Solubility (25C) * In vitro DMSO 5 mg/mL (15.25 mM)
    Water 65 mg/mL (198.27 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo Saline 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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