FlumazenilCatalog No. A10397

Quick Overview

Flumazenil, an imidazobenzodiazepine derivative, antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex. Flumazenil is a weak partial agonist in some animal models of activity, but has little or no agonist activity in humans.
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Flumazenil

Product Information
Catalog Num A10397
M. Wt 303.3
Formula C15H14FN3O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 78755-81-4
Synonyms Ro 15-1788
SMILES Code CCOC(=O)c1ncn2c1CN(C)C(=O)c1c2ccc(c1)F

Biological activity
Introduction
Flumazenil, an imidazobenzodiazepine derivative, antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex. Flumazenil is a weak partial agonist in some animal models of activity, but has little or no agonist activity in humans.
Targets
GABAA receptor
Solubility
Solubility (25C)* In vitro DMSO 5 mg/mL (16.48 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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