Fulvestrant (Faslodex)Catalog No. A10410

Quick Overview

Fulvestrant is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor.
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Fulvestrant (Faslodex)

Fulvestrant (Faslodex)  Citations(5)
  • Samy A. F. Morad,et al. Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer, Biochem Pharmacol, 2017, Apr 15; 130: 21-33 28189725
  • Kaneyasu Nishimura,et al. Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin 汐5汕1, Stem Cell Reports, 2016, Apr 12; 6(4): 511-524 26997644
  • Alejandro S. Cazzulino,et al. Improved specificity of hippocampal memory trace labeling, Hippocampus, 2016, Jun; 26(6): 752-762 26662713
  • Rie Mukai,et al. 8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice, Am J Physiol Regul Integr Comp Physiol, 2016, Dec 1;311(6):R1022-R1031 27629889
  • Sakanashi M,et al. Long-term treatment with san'o-shashin-to, a kampo medicine, markedly ameliorates cardiac ischemia-reperfusion injury in ovariectomized rats via the redox-dependent mechanism., Circ J. , 2013, 77(7):1827-37. 23615023
  • Product Information
    Catalog Num A10410
    M. Wt 606.8
    Formula C32H47F5O3S
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 129453-61-8
    Synonyms ICI 182,780 ; ICI 182780 ; ICI182780
    Chemical Name (7α,17β)-7-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1,3,5(10)-triene-3,17-diol
    SMILES Code C[[email protected]]12CC[[email protected]]3[[email protected]]([[email protected]@H]1CC[[email protected]@H]2O)[[email protected]@H](CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F

    Biological activity
    Fulvestrant is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor.
    ER (Cell-free assay)
    0.94 nM
    Solubility (25C) * In vitro DMSO 100 mg/mL (164.8 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol 100 mg/mL (164.8 mM)
    In vivo 5% DMSO/95% Corn oil 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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