Gefitinib (Iressa)

Catalog No. A10422

Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.
  • Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
  • Mansi Srivastava, .et al. Inhibition of the TIRAP-c-Jun interaction as a therapeutic strategy for AP1-mediated inflammatory responses, Int Immunopharmacol, 2019, 71: 188-197 PMID: 30909134
Catalog Num A10422
M. Wt 446.9
Formula C22H24ClFN4O3
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 184475-35-2
Synonyms ZD-1839
SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.
Targets
Tyr1173 (NR6W cells) Tyr1173 (NR6wtEGFR cells) Tyr992 (NR6wtEGFR cells) Tyr992 (NR6W cells)
26 nM37 nM37 nM57 nM
In vitro (25°C) DMSO 89 mg/mL (199.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol 4 mg/mL (8.95 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 12 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.38 mL 111.88 mL 223.76 mL
0.5 mM 4.48 mL 22.38 mL 44.75 mL
1 mM 2.24 mL 11.19 mL 22.38 mL
5 mM 0.45 mL 2.24 mL 4.48 mL

*The above data is based on the productmolecular weight 446.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.