Gemcitabine HCl (Gemzar)

Catalog No. A10423

Gemcitabine (Gemzar) is a newer chemotherapy drug acting by replacing one of the building blocks of nucleic acids during DNA replication in cancer cells, preventing tumor growth.
  • G. R. Iglesias, .et al. Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles, Polymers, 2018, 10(3), 269
Catalog Num A10423
M. Wt 299.7
Formula C9H11F2N3O4.HCI
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 122111-03-9
Synonyms
SMILES C1=CN(C(=O)N=C1N)[[email protected]]2C([[email protected]@H]([[email protected]](O2)CO)O)(F)F.Cl
Gemcitabine (Gemzar) is a newer chemotherapy drug acting by replacing one of the building blocks of nucleic acids during DNA replication in cancer cells, preventing tumor growth.
Targets
DNA synthesis (Capan2 cells) DNA synthesis (BxPC3 cells) DNA synthesis (MIAPaCa2 cells) DNA synthesis (PANC1 cells)
12 nM18 nM40 nM50 nM
In vitro (25°C) DMSO <1 mg/mL (<1 mM)
Water 19 mg/mL (63.4 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.37 mL 166.83 mL 333.67 mL
0.5 mM 6.67 mL 33.37 mL 66.73 mL
1 mM 3.34 mL 16.68 mL 33.37 mL
5 mM 0.67 mL 3.34 mL 6.67 mL

*The above data is based on the productmolecular weight 299.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.