Glimepiride

Catalog No. A10430

Glimepiride is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.

Technical details

Catalog Num	A10430
M. Wt	490.62
Formula	C24H34N4O5S
Purity	>98%
Storage	at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.	93479-97-1
Synonyms	Amary
SMILES	CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C

Biological Activity

Glimepiride is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.

Targets

SUR1	SUR2A	SUR2B
3 nM	5.4 nM	7.3 nM

Solubility *

In vitro	DMSO	10 mg/mL (20.38 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.38 mL	101.91 mL	203.82 mL
0.5 mM	4.08 mL	20.38 mL	40.76 mL
1 mM	2.04 mL	10.19 mL	20.38 mL
5 mM	0.41 mL	2.04 mL	4.08 mL

*The above data is based on the productmolecular weight 490.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.