KU-55933Catalog No. A10506

Quick Overview

KU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.
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KU-55933

KU-55933  Citations(2)
  • Hayakawa K,et al. Planar compression of extracellular substrates induces S phase arrest via ATM-independent CHK2 activation, Biochem Biophys Res Commun, 2018, Dec 2;506(4):983-989 30404732
  • Chwastek J,et al. The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a 污H2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D, Int J Biochem Cell Biol, 2017, Jun;87:38-53 28341201
  • Product Information
    Catalog Num A10506
    M. Wt 395.5
    Formula C21H17NO3S2
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 587871-26-9
    Synonyms KU55933
    Chemical Name 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
    SMILES Code C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4

    Biological activity
    Introduction
    KU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.
    Targets
    Target Value
    ATMIC50: 12.9nM
    DNA-PKIC50: 2.5μM
    mTORIC50: 9.3μM
    PI3KIC50: 16.6μM
    ATRIC50: >100μM
    PI4KIC50: >100μM
    Solubility
    Solubility (25C) * In vitro DMSO 33 mg/mL (83.44 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 5% DMSO and 47.5% PEG300 10 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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