Lenalidomide (CC-5013)Catalog No. A10522

Quick Overview

Lenalidomide is a derivative of thalidomide. In vitro, lenalidomide has three main activities: direct anti-tumor effect, inhibition of the micro environment support for tumor cells, and immunomodulatory role. It induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity.
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Lenalidomide (CC-5013)

Lenalidomide (CC-5013)  Citations(2)
  • Kumar R,et al. Novel combination of tanshinone I and lenalidomide induces chemo-sensitivity in myeloma cells by modulating telomerase activity and expression of shelterin complex and its associated molecules, Mol Biol Rep, 2018, Oct 11 30311125
  • Hirosumi Tamura,et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 29917168
  • Product Information
    Catalog Num A10522
    M. Wt 259.3
    Formula C13H13N3O3
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 191732-72-6
    Synonyms CC-5013, Revlimid
    Chemical Name (RS)-3-(4-amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione
    SMILES Code C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N

    Biological activity
    Introduction
    Lenalidomide is a derivative of thalidomide. In vitro, lenalidomide has three main activities: direct anti-tumor effect, inhibition of the micro environment support for tumor cells, and immunomodulatory role. It induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity.
    Solubility
    Solubility (25C) * In vitro DMSO 52 mg/mL (200.57 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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